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Prediction of disease-related mutations affecting protein localization.

Laurila, Kirsti and Vihinen, Mauno LU (2009) In BMC Genomics 10.
Abstract
Eukaryotic cells contain numerous compartments, which have different protein constituents. Proteins are typically directed to compartments by short peptide sequences that act as targeting signals. Translocation to the proper compartment allows a protein to form the necessary interactions with its partners and take part in biological networks such as signalling and metabolic pathways. If a protein is not transported to the correct intracellular compartment either the reaction performed or information carried by the protein does not reach the proper site, causing either inactivation of central reactions or misregulation of signalling cascades, or the mislocalized active protein has harmful effects by acting in the wrong place.
Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Computational Biology: methods, Genetic Predisposition to Disease: genetics, Intracellular Space: metabolism, Proteins: genetics, Proteins: metabolism
in
BMC Genomics
volume
10
publisher
BioMed Central
external identifiers
  • pmid:19309509
  • scopus:65649116597
ISSN
1471-2164
DOI
10.1186/1471-2164-10-122
language
English
LU publication?
no
id
b38dcc12-0f14-43aa-a97b-c69b158f00cc (old id 3634817)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19309509?dopt=Abstract
date added to LUP
2013-06-12 20:37:41
date last changed
2017-08-27 05:55:31
@article{b38dcc12-0f14-43aa-a97b-c69b158f00cc,
  abstract     = {Eukaryotic cells contain numerous compartments, which have different protein constituents. Proteins are typically directed to compartments by short peptide sequences that act as targeting signals. Translocation to the proper compartment allows a protein to form the necessary interactions with its partners and take part in biological networks such as signalling and metabolic pathways. If a protein is not transported to the correct intracellular compartment either the reaction performed or information carried by the protein does not reach the proper site, causing either inactivation of central reactions or misregulation of signalling cascades, or the mislocalized active protein has harmful effects by acting in the wrong place.},
  articleno    = {122},
  author       = {Laurila, Kirsti and Vihinen, Mauno},
  issn         = {1471-2164},
  keyword      = {Computational Biology: methods,Genetic Predisposition to Disease: genetics,Intracellular Space: metabolism,Proteins: genetics,Proteins: metabolism},
  language     = {eng},
  publisher    = {BioMed Central},
  series       = {BMC Genomics},
  title        = {Prediction of disease-related mutations affecting protein localization.},
  url          = {http://dx.doi.org/10.1186/1471-2164-10-122},
  volume       = {10},
  year         = {2009},
}