Prediction of disease-related mutations affecting protein localization.
Laurila, Kirsti and Vihinen, Mauno LU
(2009)
In BMC Genomics
10.
- Abstract
- Eukaryotic cells contain numerous compartments, which have different protein constituents. Proteins are typically directed to compartments by short peptide sequences that act as targeting signals. Translocation to the proper compartment allows a protein to form the necessary interactions with its partners and take part in biological networks such as signalling and metabolic pathways. If a protein is not transported to the correct intracellular compartment either the reaction performed or information carried by the protein does not reach the proper site, causing either inactivation of central reactions or misregulation of signalling cascades, or the mislocalized active protein has harmful effects by acting in the wrong place.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3634817
- author
- Laurila, Kirsti
and Vihinen, Mauno
LU
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Computational Biology: methods, Genetic Predisposition to Disease: genetics, Intracellular Space: metabolism, Proteins: genetics, Proteins: metabolism
- in
- BMC Genomics
- volume
- 10
- article number
- 122
- publisher
- BioMed Central (BMC)
- external identifiers
-
- pmid:19309509
- scopus:65649116597
- pmid:19309509
- ISSN
- 1471-2164
- DOI
- 10.1186/1471-2164-10-122
- language
- English
- LU publication?
- no
- id
- b38dcc12-0f14-43aa-a97b-c69b158f00cc (old id 3634817)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19309509?dopt=Abstract
- date added to LUP
- 2016-04-04 09:43:20
- date last changed
- 2022-01-29 19:15:47
@article{b38dcc12-0f14-43aa-a97b-c69b158f00cc,
abstract = {{Eukaryotic cells contain numerous compartments, which have different protein constituents. Proteins are typically directed to compartments by short peptide sequences that act as targeting signals. Translocation to the proper compartment allows a protein to form the necessary interactions with its partners and take part in biological networks such as signalling and metabolic pathways. If a protein is not transported to the correct intracellular compartment either the reaction performed or information carried by the protein does not reach the proper site, causing either inactivation of central reactions or misregulation of signalling cascades, or the mislocalized active protein has harmful effects by acting in the wrong place.}},
author = {{Laurila, Kirsti and Vihinen, Mauno}},
issn = {{1471-2164}},
keywords = {{Computational Biology: methods; Genetic Predisposition to Disease: genetics; Intracellular Space: metabolism; Proteins: genetics; Proteins: metabolism}},
language = {{eng}},
publisher = {{BioMed Central (BMC)}},
series = {{BMC Genomics}},
title = {{Prediction of disease-related mutations affecting protein localization.}},
url = {{http://dx.doi.org/10.1186/1471-2164-10-122}},
doi = {{10.1186/1471-2164-10-122}},
volume = {{10}},
year = {{2009}},
}