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Phylogeny of Tec family kinases identification of a premetazoan origin of Btk, Bmx, Itk, Tec, Txk, and the Btk regulator SH3BP5.

Ortutay, Csaba; Nore, Beston F; Vihinen, Mauno LU and Smith, C I Edvard (2008) In Advances in Genetics 64. p.51-80
Abstract
It is generally considered mammals and birds have five Tec family kinases (TFKs): Btk, Bmx (also known as Etk), Itk, Tec, and Txk (also known as Rlk). Here, we discuss the domains and their functions and regulation in TFKs. Over the last few years, a large number of genomes from various phyla have been sequenced making it possible to study evolutionary relationships at the molecular and sequence level. Using bioinformatics tools, we for the first time demonstrate that a TFK ancestor exists in the unicellular choanoflagellate Monosiga brevicollis, which is the closest known relative to metazoans with a sequenced genome. The analysis of the genomes for sponges, insects, hagfish, and frogs suggests that these species encode a single TFK. The... (More)
It is generally considered mammals and birds have five Tec family kinases (TFKs): Btk, Bmx (also known as Etk), Itk, Tec, and Txk (also known as Rlk). Here, we discuss the domains and their functions and regulation in TFKs. Over the last few years, a large number of genomes from various phyla have been sequenced making it possible to study evolutionary relationships at the molecular and sequence level. Using bioinformatics tools, we for the first time demonstrate that a TFK ancestor exists in the unicellular choanoflagellate Monosiga brevicollis, which is the closest known relative to metazoans with a sequenced genome. The analysis of the genomes for sponges, insects, hagfish, and frogs suggests that these species encode a single TFK. The insect form has a divergent and unique N-terminal region. Duplications generating the five members took place prior to the emergence of vertebrates. Fishes have two or three forms and the platypus, Ornithorhynchus anatinus, has four (lacks Txk). Thus, not all mammals have all five TFKs. The single identified TFK in frogs is an ortholog of Tec. Bmx seems to be unique to mammals and birds. SH3BP5 is a negative regulator of Btk. It is conserved in choanoflagellates and interestingly exists also in nematodes, which do not express TFKs, suggesting a broader function in addition to Btk regulation. The related SH3BP5-like protein is not found in Nematodes. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Chickens: genetics, Mammals: genetics, Phosphatidylinositol 3-Kinases: genetics, Phosphatidylinositol 3-Kinases: metabolism, Protein-Tyrosine Kinases: chemistry, Protein-Tyrosine Kinases: classification, Protein-Tyrosine Kinases: genetics
in
Advances in Genetics
volume
64
pages
51 - 80
publisher
Academic Press
external identifiers
  • PMID:19161832
  • Scopus:58249090833
ISSN
0065-2660
DOI
10.1016/S0065-2660(08)00803-1
language
English
LU publication?
no
id
13109cb1-8c68-4720-b904-abae55019c9a (old id 3634959)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19161832?dopt=Abstract
date added to LUP
2013-06-12 16:36:04
date last changed
2017-01-15 04:27:16
@article{13109cb1-8c68-4720-b904-abae55019c9a,
  abstract     = {It is generally considered mammals and birds have five Tec family kinases (TFKs): Btk, Bmx (also known as Etk), Itk, Tec, and Txk (also known as Rlk). Here, we discuss the domains and their functions and regulation in TFKs. Over the last few years, a large number of genomes from various phyla have been sequenced making it possible to study evolutionary relationships at the molecular and sequence level. Using bioinformatics tools, we for the first time demonstrate that a TFK ancestor exists in the unicellular choanoflagellate Monosiga brevicollis, which is the closest known relative to metazoans with a sequenced genome. The analysis of the genomes for sponges, insects, hagfish, and frogs suggests that these species encode a single TFK. The insect form has a divergent and unique N-terminal region. Duplications generating the five members took place prior to the emergence of vertebrates. Fishes have two or three forms and the platypus, Ornithorhynchus anatinus, has four (lacks Txk). Thus, not all mammals have all five TFKs. The single identified TFK in frogs is an ortholog of Tec. Bmx seems to be unique to mammals and birds. SH3BP5 is a negative regulator of Btk. It is conserved in choanoflagellates and interestingly exists also in nematodes, which do not express TFKs, suggesting a broader function in addition to Btk regulation. The related SH3BP5-like protein is not found in Nematodes.},
  author       = {Ortutay, Csaba and Nore, Beston F and Vihinen, Mauno and Smith, C I Edvard},
  issn         = {0065-2660},
  keyword      = {Chickens: genetics,Mammals: genetics,Phosphatidylinositol 3-Kinases: genetics,Phosphatidylinositol 3-Kinases: metabolism,Protein-Tyrosine Kinases: chemistry,Protein-Tyrosine Kinases: classification,Protein-Tyrosine Kinases: genetics},
  language     = {eng},
  pages        = {51--80},
  publisher    = {Academic Press},
  series       = {Advances in Genetics},
  title        = {Phylogeny of Tec family kinases identification of a premetazoan origin of Btk, Bmx, Itk, Tec, Txk, and the Btk regulator SH3BP5.},
  url          = {http://dx.doi.org/10.1016/S0065-2660(08)00803-1},
  volume       = {64},
  year         = {2008},
}