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Molecular characterization of the immune system: emergence of proteins, processes, and domains.

Ortutay, Csaba; Siermala, Markku and Vihinen, Mauno LU (2007) In Immunogenetics 59(5). p.333-348
Abstract
Many genes and proteins are required to carry out the processes of innate and adaptive immunity. For many studies, including systems biology, it is necessary to have a clear and comprehensive definition of the immune system, including the genes and proteins that take part in immunological processes. We have identified and cataloged a large portion of the human immunology-related genes, which we call the essential immunome. The 847 identified genes and proteins were annotated, and their chromosomal localizations were compared to the mouse genome. Relation to disease was also taken into account. We identified numerous pseudogenes, many of which are expressed, and found two putative new genes. We also carried out an evolutionary analysis of... (More)
Many genes and proteins are required to carry out the processes of innate and adaptive immunity. For many studies, including systems biology, it is necessary to have a clear and comprehensive definition of the immune system, including the genes and proteins that take part in immunological processes. We have identified and cataloged a large portion of the human immunology-related genes, which we call the essential immunome. The 847 identified genes and proteins were annotated, and their chromosomal localizations were compared to the mouse genome. Relation to disease was also taken into account. We identified numerous pseudogenes, many of which are expressed, and found two putative new genes. We also carried out an evolutionary analysis of immune processes based on gene orthologs to gain an overview of the evolutionary past and molecular present of the human immune system. A list of genes and proteins were compiled. A comprehensive characterization of the member genes and proteins, including the corresponding pseudogenes is presented. Immunome genes were found to have three types of emergence in independent studies of their ontologies, domains, and functions. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Immunity: genetics, Human: genetics, Chromosomes, Immune System: immunology, Proteins: classification, Proteins: genetics
in
Immunogenetics
volume
59
issue
5
pages
333 - 348
publisher
Springer
external identifiers
  • PMID:17294181
  • Scopus:34047199156
ISSN
1432-1211
DOI
10.1007/s00251-007-0191-0
language
English
LU publication?
no
id
179ff39f-e0d1-44f1-a224-0beaed42bf82 (old id 3635326)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/17294181?dopt=Abstract
date added to LUP
2013-06-12 16:19:58
date last changed
2017-01-01 07:48:54
@article{179ff39f-e0d1-44f1-a224-0beaed42bf82,
  abstract     = {Many genes and proteins are required to carry out the processes of innate and adaptive immunity. For many studies, including systems biology, it is necessary to have a clear and comprehensive definition of the immune system, including the genes and proteins that take part in immunological processes. We have identified and cataloged a large portion of the human immunology-related genes, which we call the essential immunome. The 847 identified genes and proteins were annotated, and their chromosomal localizations were compared to the mouse genome. Relation to disease was also taken into account. We identified numerous pseudogenes, many of which are expressed, and found two putative new genes. We also carried out an evolutionary analysis of immune processes based on gene orthologs to gain an overview of the evolutionary past and molecular present of the human immune system. A list of genes and proteins were compiled. A comprehensive characterization of the member genes and proteins, including the corresponding pseudogenes is presented. Immunome genes were found to have three types of emergence in independent studies of their ontologies, domains, and functions.},
  author       = {Ortutay, Csaba and Siermala, Markku and Vihinen, Mauno},
  issn         = {1432-1211},
  keyword      = {Immunity: genetics,Human: genetics,Chromosomes,Immune System: immunology,Proteins: classification,Proteins: genetics},
  language     = {eng},
  number       = {5},
  pages        = {333--348},
  publisher    = {Springer},
  series       = {Immunogenetics},
  title        = {Molecular characterization of the immune system: emergence of proteins, processes, and domains.},
  url          = {http://dx.doi.org/10.1007/s00251-007-0191-0},
  volume       = {59},
  year         = {2007},
}