Navelstrengbloed van een onverwante donor als bron voor stamceltransplantaties bij aangeboren stofwisselingsziekten
(2008) In Nederlands Tijdschrift voor Geneeskunde 152(31). p.1719-1724- Abstract
- In certain inborn errors of metabolism, an allogeneic stem cell transplantation is able to prevent disease progression. - This is only possible when the stem cell transplantation (SCT) is performed early in life, before cerebral involvement has occurred. - In addition to bone marrow and peripheral blood, unrelated umbilical cord blood appears to be an effective stem cell source as well. - There are also potential disadvantages attached to the use of umbilical blood as stem cell source: the possibility of only one donation per donor and less adaptive immunity following umbilical blood SCT with an increased risk of reactivation of a previous viral infection. However, these disadvantages are less applicable to young children with inborn... (More)
- In certain inborn errors of metabolism, an allogeneic stem cell transplantation is able to prevent disease progression. - This is only possible when the stem cell transplantation (SCT) is performed early in life, before cerebral involvement has occurred. - In addition to bone marrow and peripheral blood, unrelated umbilical cord blood appears to be an effective stem cell source as well. - There are also potential disadvantages attached to the use of umbilical blood as stem cell source: the possibility of only one donation per donor and less adaptive immunity following umbilical blood SCT with an increased risk of reactivation of a previous viral infection. However, these disadvantages are less applicable to young children with inborn errors of metabolism. - The improvement of transplantation techniques and the availability of this new stem cell source could improve the success rate of this procedure and consequently the prognosis of these severely affected patients.
(Less)
- author
- Aldenhoven, M. ; De Koning, T. J. LU ; Wulffraat, N. M. and Boelens, J. J.
- alternative title
- Unrelated umbilical cord blood as source for stem cell transplantations in inborn errors of metabolism
- publishing date
- 2008-08-02
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nederlands Tijdschrift voor Geneeskunde
- volume
- 152
- issue
- 31
- pages
- 6 pages
- publisher
- Bohn Stafleu van Loghum
- external identifiers
-
- scopus:49749112312
- pmid:18727602
- ISSN
- 0028-2162
- language
- Dutch
- LU publication?
- no
- id
- 36479826-dd26-4db6-9af8-f1e083c3d935
- date added to LUP
- 2020-02-28 13:53:10
- date last changed
- 2024-04-03 03:55:16
@article{36479826-dd26-4db6-9af8-f1e083c3d935,
abstract = {{<p>- In certain inborn errors of metabolism, an allogeneic stem cell transplantation is able to prevent disease progression. - This is only possible when the stem cell transplantation (SCT) is performed early in life, before cerebral involvement has occurred. - In addition to bone marrow and peripheral blood, unrelated umbilical cord blood appears to be an effective stem cell source as well. - There are also potential disadvantages attached to the use of umbilical blood as stem cell source: the possibility of only one donation per donor and less adaptive immunity following umbilical blood SCT with an increased risk of reactivation of a previous viral infection. However, these disadvantages are less applicable to young children with inborn errors of metabolism. - The improvement of transplantation techniques and the availability of this new stem cell source could improve the success rate of this procedure and consequently the prognosis of these severely affected patients.</p>}},
author = {{Aldenhoven, M. and De Koning, T. J. and Wulffraat, N. M. and Boelens, J. J.}},
issn = {{0028-2162}},
language = {{mis}},
month = {{08}},
number = {{31}},
pages = {{1719--1724}},
publisher = {{Bohn Stafleu van Loghum}},
series = {{Nederlands Tijdschrift voor Geneeskunde}},
title = {{Navelstrengbloed van een onverwante donor als bron voor stamceltransplantaties bij aangeboren stofwisselingsziekten}},
volume = {{152}},
year = {{2008}},
}