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Epidemiology of fungaemia in Sweden : A nationwide retrospective observational survey

Klingspor, Lena; Ullberg, Måns; Rydberg, Johan LU ; Kondori, Nahid; Serrander, Lena; Swanberg, Jonas; Nilsson, Kenneth; Jendle Bengtén, Cecilia; Johansson, Marcus and Granlund, Margareta, et al. (2018) In Mycoses 61(10). p.777-785
Abstract

Objectives: To identify the epidemiology and antifungal susceptibilities of Candida spp. among blood culture isolates to identify the epidemiology and antifungal susceptibilities of Candida spp. among blood culture isolates in Sweden. Methods: The study was a retrospective, observational nationwide laboratory-based surveillance for fungaemia and fungal meningitis and was conducted from September 2015 to August 2016. Results: In total, 488 Candida blood culture isolates were obtained from 471 patients (58% males). Compared to our previous study, the incidence of candidaemia has increased from 4.2/100 000 (2005-2006) to 4.7/100 000 population/year (2015-2016). The three most common Candida spp. isolated from blood cultures were Candida... (More)

Objectives: To identify the epidemiology and antifungal susceptibilities of Candida spp. among blood culture isolates to identify the epidemiology and antifungal susceptibilities of Candida spp. among blood culture isolates in Sweden. Methods: The study was a retrospective, observational nationwide laboratory-based surveillance for fungaemia and fungal meningitis and was conducted from September 2015 to August 2016. Results: In total, 488 Candida blood culture isolates were obtained from 471 patients (58% males). Compared to our previous study, the incidence of candidaemia has increased from 4.2/100 000 (2005-2006) to 4.7/100 000 population/year (2015-2016). The three most common Candida spp. isolated from blood cultures were Candida albicans (54.7%), Candida glabrata (19.7%) and species in the Candida parapsilosis complex (9.4%). Candida resistance to fluconazole was 2% in C. albicans and between 0% and 100%, in non-albicans species other than C. glabrata and C. krusei. Resistance to voriconazole was rare, except for C. glabrata, C. krusei and C. tropicalis. Resistance to anidulafungin was 3.8% while no Candida isolate was resistant to amphotericin B. Conclusions: We report an overall increase in candidaemia but a minor decrease of C. albicans while C. glabrata and C. parapsilosis remain constant over this 10-year period.

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publication status
published
subject
keywords
Candida, Cryptococcus, Antifungal susceptibility, Candidaemia, Fungaemia epidemiology, Fungal meningitis epidemiology, Incidence
in
Mycoses
volume
61
issue
10
pages
777 - 785
publisher
Wiley-Blackwell
external identifiers
  • scopus:85050680986
ISSN
0933-7407
DOI
10.1111/myc.12816
language
English
LU publication?
yes
id
366616df-9685-420f-b999-80dcda1ce7f2
date added to LUP
2018-09-11 11:25:30
date last changed
2019-01-14 17:05:57
@article{366616df-9685-420f-b999-80dcda1ce7f2,
  abstract     = {<p>Objectives: To identify the epidemiology and antifungal susceptibilities of Candida spp. among blood culture isolates to identify the epidemiology and antifungal susceptibilities of Candida spp. among blood culture isolates in Sweden. Methods: The study was a retrospective, observational nationwide laboratory-based surveillance for fungaemia and fungal meningitis and was conducted from September 2015 to August 2016. Results: In total, 488 Candida blood culture isolates were obtained from 471 patients (58% males). Compared to our previous study, the incidence of candidaemia has increased from 4.2/100 000 (2005-2006) to 4.7/100 000 population/year (2015-2016). The three most common Candida spp. isolated from blood cultures were Candida albicans (54.7%), Candida glabrata (19.7%) and species in the Candida parapsilosis complex (9.4%). Candida resistance to fluconazole was 2% in C. albicans and between 0% and 100%, in non-albicans species other than C. glabrata and C. krusei. Resistance to voriconazole was rare, except for C. glabrata, C. krusei and C. tropicalis. Resistance to anidulafungin was 3.8% while no Candida isolate was resistant to amphotericin B. Conclusions: We report an overall increase in candidaemia but a minor decrease of C. albicans while C. glabrata and C. parapsilosis remain constant over this 10-year period.</p>},
  author       = {Klingspor, Lena and Ullberg, Måns and Rydberg, Johan and Kondori, Nahid and Serrander, Lena and Swanberg, Jonas and Nilsson, Kenneth and Jendle Bengtén, Cecilia and Johansson, Marcus and Granlund, Margareta and Törnqvist, Eva and Nyberg, Anders and Kindlund, Karin and Ygge, Minna and Kartout-Boukdir, Dalila and Toepfer, Michael and Hålldin, Eva and Kahlmeter, Gunnar and Özenci, Volkan},
  issn         = {0933-7407},
  keyword      = {Candida,Cryptococcus,Antifungal susceptibility,Candidaemia,Fungaemia epidemiology,Fungal meningitis epidemiology,Incidence},
  language     = {eng},
  month        = {01},
  number       = {10},
  pages        = {777--785},
  publisher    = {Wiley-Blackwell},
  series       = {Mycoses},
  title        = {Epidemiology of fungaemia in Sweden : A nationwide retrospective observational survey},
  url          = {http://dx.doi.org/10.1111/myc.12816},
  volume       = {61},
  year         = {2018},
}