High genetic contribution to anterior cruciate ligament rupture : Heritability ∼69%
(2020) In British journal of sports medicine- Abstract
Objectives: We aimed to determine the lifetime genetic risk for anterior cruciate ligament (ACL) rupture. Methods: We used a twin study approach, linking the Swedish Twin Register with national healthcare data to form a 30 year, population wide, longitudinal twin cohort. We studied ACL rupture in this cohort of 88 414 identical and fraternal twin pairs, aged ≥17 years, to determine the familial risk and heritability of ACL rupture. Results: The incidence rate of ACL rupture was 70 (95% CI 66 to 74) per 100 000 person years. The familial risk, which is the excess risk ratio (RR) of the second twin having ACL rupture given that the first twin has had such a rupture, was higher in identical twin pairs (RR=8.6, 95% CI 6.2 to 11.0) than in... (More)
Objectives: We aimed to determine the lifetime genetic risk for anterior cruciate ligament (ACL) rupture. Methods: We used a twin study approach, linking the Swedish Twin Register with national healthcare data to form a 30 year, population wide, longitudinal twin cohort. We studied ACL rupture in this cohort of 88 414 identical and fraternal twin pairs, aged ≥17 years, to determine the familial risk and heritability of ACL rupture. Results: The incidence rate of ACL rupture was 70 (95% CI 66 to 74) per 100 000 person years. The familial risk, which is the excess risk ratio (RR) of the second twin having ACL rupture given that the first twin has had such a rupture, was higher in identical twin pairs (RR=8.6, 95% CI 6.2 to 11.0) than in fraternal twin pairs (RR=1.9, 95% CI 0.9 to 3.0). The overall heritability of ACL rupture was high, 69% (95% CI 47 to 91), increasing from 60% at age 17 years to 80% at age 60 years. Women and men had similar familial risk and heritability of ACL rupture. Conclusion: The genetic contribution to ACL rupture of ∼69% is high and suggests strong familial clustering. If clinicians recognise the high genetic risk of such injury, they may be better able to counsel athletes whose near relatives have had ACL rupture.
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- author
- Magnusson, Karin LU ; Turkiewicz, Aleksandra LU ; Hughes, Velocity LU ; Frobell, Richard LU and Englund, Martin LU
- organization
- publishing date
- 2020
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- ACL, contact sports, epidemiology, genetics, injury prevention
- in
- British journal of sports medicine
- publisher
- BMJ Publishing Group
- external identifiers
-
- pmid:33288618
- scopus:85097410195
- ISSN
- 0306-3674
- DOI
- 10.1136/bjsports-2020-102392
- language
- English
- LU publication?
- yes
- id
- 366966ff-2c34-485e-9cc9-41da7c748438
- date added to LUP
- 2020-12-22 11:45:37
- date last changed
- 2024-09-19 12:01:42
@article{366966ff-2c34-485e-9cc9-41da7c748438, abstract = {{<p>Objectives: We aimed to determine the lifetime genetic risk for anterior cruciate ligament (ACL) rupture. Methods: We used a twin study approach, linking the Swedish Twin Register with national healthcare data to form a 30 year, population wide, longitudinal twin cohort. We studied ACL rupture in this cohort of 88 414 identical and fraternal twin pairs, aged ≥17 years, to determine the familial risk and heritability of ACL rupture. Results: The incidence rate of ACL rupture was 70 (95% CI 66 to 74) per 100 000 person years. The familial risk, which is the excess risk ratio (RR) of the second twin having ACL rupture given that the first twin has had such a rupture, was higher in identical twin pairs (RR=8.6, 95% CI 6.2 to 11.0) than in fraternal twin pairs (RR=1.9, 95% CI 0.9 to 3.0). The overall heritability of ACL rupture was high, 69% (95% CI 47 to 91), increasing from 60% at age 17 years to 80% at age 60 years. Women and men had similar familial risk and heritability of ACL rupture. Conclusion: The genetic contribution to ACL rupture of ∼69% is high and suggests strong familial clustering. If clinicians recognise the high genetic risk of such injury, they may be better able to counsel athletes whose near relatives have had ACL rupture. </p>}}, author = {{Magnusson, Karin and Turkiewicz, Aleksandra and Hughes, Velocity and Frobell, Richard and Englund, Martin}}, issn = {{0306-3674}}, keywords = {{ACL; contact sports; epidemiology; genetics; injury prevention}}, language = {{eng}}, publisher = {{BMJ Publishing Group}}, series = {{British journal of sports medicine}}, title = {{High genetic contribution to anterior cruciate ligament rupture : Heritability ∼69%}}, url = {{http://dx.doi.org/10.1136/bjsports-2020-102392}}, doi = {{10.1136/bjsports-2020-102392}}, year = {{2020}}, }