Hemodynamic effects of colloid concentration in experimental hemorrhage: a comparison of Ringer's acetate, 3% dextran-60, and 6% dextran-70.
(1988) In Critical Care Medicine 16(4). p.346-352- Abstract
- Hemodynamic effects of iso-oncotic 3% dextran-60, 6% dextran-70, and Ringer's acetate were compared in 28 male pigs (25 to 30 kg) subjected to experimental trauma and hemorrhage. The animals were kept anesthetized with 75% N2O/25% O2, 0.8% halothane. Hemodynamic and respiratory conditions were allowed to stabilize for one hour preoperatively (baseline data). After surgical trauma (arthroplasty), three 0.5 L of arterial blood samples were withdrawn and replaced with autologous red cells mixed with one liter of 3% dextran-60 in one group 1 (n = 9), one liter of 6% dextran-70 in group 2 (n = 10), and 3 L of Ringer's acetate in group 3 (n = 9). Pulmonary capillary wedge pressure (WP) was kept at baseline level for a further 10 h with infusion... (More)
- Hemodynamic effects of iso-oncotic 3% dextran-60, 6% dextran-70, and Ringer's acetate were compared in 28 male pigs (25 to 30 kg) subjected to experimental trauma and hemorrhage. The animals were kept anesthetized with 75% N2O/25% O2, 0.8% halothane. Hemodynamic and respiratory conditions were allowed to stabilize for one hour preoperatively (baseline data). After surgical trauma (arthroplasty), three 0.5 L of arterial blood samples were withdrawn and replaced with autologous red cells mixed with one liter of 3% dextran-60 in one group 1 (n = 9), one liter of 6% dextran-70 in group 2 (n = 10), and 3 L of Ringer's acetate in group 3 (n = 9). Pulmonary capillary wedge pressure (WP) was kept at baseline level for a further 10 h with infusion of the respective fluid; for this purpose, groups 1 through 3 needed additional infusions of 0.8 +/- 0.3, 0.5 +/- 0.4, and 5.3 +/- 3 (SD) L, respectively. Group 1 showed the highest jejunal capillary blood flow at 10 h and the lowest intragroup variations in hemodynamic and respiratory data. Group 2 had the highest pulmonary arterial pressures and group 3 had the lowest colloid oncotic and arterial BP and left ventricular volume indices. In group 3, the Hct and serum albumin indicated insufficient plasma volume replacement. This group had a significantly larger (p less than .05) amount of tissue water in skin, skeletal muscle, and jejunum than the other groups; no significant difference in lung or heart muscle water was found between the groups.(ABSTRACT TRUNCATED AT 250 WORDS) (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3634409
- author
- Schött, Ulf LU ; Lindbom, L O and Sjöstrand, U
- publishing date
- 1988
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Colloids: pharmacology, Dextrans: pharmacology, Hemodynamics: drug effects, Isotonic Solutions: pharmacology
- in
- Critical Care Medicine
- volume
- 16
- issue
- 4
- pages
- 346 - 352
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- pmid:2450720
- scopus:0023882635
- ISSN
- 1530-0293
- project
- Koagulation vid kirurgi och kritisk sjukdom
- language
- English
- LU publication?
- no
- id
- 36c4555b-98fc-4fde-ab1c-bcecd41b0e5e (old id 3634409)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/2450720?dopt=Abstract
- date added to LUP
- 2016-04-04 09:39:26
- date last changed
- 2021-09-19 03:46:27
@article{36c4555b-98fc-4fde-ab1c-bcecd41b0e5e,
abstract = {{Hemodynamic effects of iso-oncotic 3% dextran-60, 6% dextran-70, and Ringer's acetate were compared in 28 male pigs (25 to 30 kg) subjected to experimental trauma and hemorrhage. The animals were kept anesthetized with 75% N2O/25% O2, 0.8% halothane. Hemodynamic and respiratory conditions were allowed to stabilize for one hour preoperatively (baseline data). After surgical trauma (arthroplasty), three 0.5 L of arterial blood samples were withdrawn and replaced with autologous red cells mixed with one liter of 3% dextran-60 in one group 1 (n = 9), one liter of 6% dextran-70 in group 2 (n = 10), and 3 L of Ringer's acetate in group 3 (n = 9). Pulmonary capillary wedge pressure (WP) was kept at baseline level for a further 10 h with infusion of the respective fluid; for this purpose, groups 1 through 3 needed additional infusions of 0.8 +/- 0.3, 0.5 +/- 0.4, and 5.3 +/- 3 (SD) L, respectively. Group 1 showed the highest jejunal capillary blood flow at 10 h and the lowest intragroup variations in hemodynamic and respiratory data. Group 2 had the highest pulmonary arterial pressures and group 3 had the lowest colloid oncotic and arterial BP and left ventricular volume indices. In group 3, the Hct and serum albumin indicated insufficient plasma volume replacement. This group had a significantly larger (p less than .05) amount of tissue water in skin, skeletal muscle, and jejunum than the other groups; no significant difference in lung or heart muscle water was found between the groups.(ABSTRACT TRUNCATED AT 250 WORDS)}},
author = {{Schött, Ulf and Lindbom, L O and Sjöstrand, U}},
issn = {{1530-0293}},
keywords = {{Colloids: pharmacology; Dextrans: pharmacology; Hemodynamics: drug effects; Isotonic Solutions: pharmacology}},
language = {{eng}},
number = {{4}},
pages = {{346--352}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{Critical Care Medicine}},
title = {{Hemodynamic effects of colloid concentration in experimental hemorrhage: a comparison of Ringer's acetate, 3% dextran-60, and 6% dextran-70.}},
url = {{http://www.ncbi.nlm.nih.gov/pubmed/2450720?dopt=Abstract}},
volume = {{16}},
year = {{1988}},
}