Screening for Prostate Cancer: Early Detection or Overdetection?
Vickers, Andrew J. ; Roobol, Monique J. and Lilja, Hans LU
(2012)
In Annual Review of Medicine
63.
p.161-170
- Abstract
- A sophisticated reading of the randomized trial evidence suggests that, although screening for prostate cancer with prostate-specific antigen (PSA) can reduce cancer-specific mortality, it does so at considerable cost in terms of the number of men who need to be screened, biopsied, and treated to prevent one death. The challenge is to design screening programs that maximize benefits (reducing prostate cancer mortality) and minimize costs (overtreatment). Recent research has suggested that this can be achieved by risk-stratifying screening and biopsy; increasing reliance on active surveillance for low-risk cancer; restricting radical prostatectomy to high-volume surgeons; and using appropriately high-dose radiotherapy. In current U. S.... (More)
- A sophisticated reading of the randomized trial evidence suggests that, although screening for prostate cancer with prostate-specific antigen (PSA) can reduce cancer-specific mortality, it does so at considerable cost in terms of the number of men who need to be screened, biopsied, and treated to prevent one death. The challenge is to design screening programs that maximize benefits (reducing prostate cancer mortality) and minimize costs (overtreatment). Recent research has suggested that this can be achieved by risk-stratifying screening and biopsy; increasing reliance on active surveillance for low-risk cancer; restricting radical prostatectomy to high-volume surgeons; and using appropriately high-dose radiotherapy. In current U. S. practice, however, many men who are screened are unlikely to benefit, most men found to have low-risk cancers are referred for unnecessary curative treatment, and much treatment is given at low-volume centers. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2571462
- author
- Vickers, Andrew J.
; Roobol, Monique J.
and Lilja, Hans
LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- prostatic neoplasms, prostate-specific antigen (PSA), surgery, radiotherapy
- in
- Annual Review of Medicine
- volume
- 63
- pages
- 161 - 170
- publisher
- Annual Reviews
- external identifiers
-
- wos:000301838400010
- scopus:84855953876
- pmid:22053739
- ISSN
- 0066-4219
- DOI
- 10.1146/annurev-med-050710-134421
- language
- English
- LU publication?
- yes
- id
- 36e1c075-0b62-4d41-9c13-5f94f53b893b (old id 2571462)
- date added to LUP
- 2016-04-01 10:28:15
- date last changed
- 2022-04-20 02:33:51
@article{36e1c075-0b62-4d41-9c13-5f94f53b893b,
abstract = {{A sophisticated reading of the randomized trial evidence suggests that, although screening for prostate cancer with prostate-specific antigen (PSA) can reduce cancer-specific mortality, it does so at considerable cost in terms of the number of men who need to be screened, biopsied, and treated to prevent one death. The challenge is to design screening programs that maximize benefits (reducing prostate cancer mortality) and minimize costs (overtreatment). Recent research has suggested that this can be achieved by risk-stratifying screening and biopsy; increasing reliance on active surveillance for low-risk cancer; restricting radical prostatectomy to high-volume surgeons; and using appropriately high-dose radiotherapy. In current U. S. practice, however, many men who are screened are unlikely to benefit, most men found to have low-risk cancers are referred for unnecessary curative treatment, and much treatment is given at low-volume centers.}},
author = {{Vickers, Andrew J. and Roobol, Monique J. and Lilja, Hans}},
issn = {{0066-4219}},
keywords = {{prostatic neoplasms; prostate-specific antigen (PSA); surgery; radiotherapy}},
language = {{eng}},
pages = {{161--170}},
publisher = {{Annual Reviews}},
series = {{Annual Review of Medicine}},
title = {{Screening for Prostate Cancer: Early Detection or Overdetection?}},
url = {{http://dx.doi.org/10.1146/annurev-med-050710-134421}},
doi = {{10.1146/annurev-med-050710-134421}},
volume = {{63}},
year = {{2012}},
}