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Relation of Retinopathy of Prematurity to Brain Volumes at Term Equivalent Age and Developmental Outcome at 2 Years of Corrected Age in Very Preterm Infants

Sveinsdóttir, Kristbjörg LU ; Ley, David LU ; Hövel, Holger LU ; Fellman, Vineta LU ; Hüppi, Petra S.; Smith, Lois E.H.; Hellström, Ann LU and Hansen Pupp, Ingrid LU (2018) In Neonatology 114(1). p.46-52
Abstract

Background: Retinopathy of prematurity (ROP) is a major complication of preterm birth and has been associated with later visual and nonvisual impairments. Objectives: To evaluate relationships between any stage of ROP, brain volumes, and developmental outcomes. Methods: This study included 52 very preterm infants (gestational age [mean ± SD]: 26.4 ± 1.9 weeks). Total brain, gray matter, unmyelinated white matter (UWMV), and cerebellar volumes were estimated in 51 out of 52 infants by magnetic resonance imaging at term-equivalent age. Bayley Scales of Infant Development were used to assess developmental outcomes in 49 out of 52 infants at a mean corrected age of 24.6 months. Results: Nineteen out of 52 infants developed any stage of ROP.... (More)

Background: Retinopathy of prematurity (ROP) is a major complication of preterm birth and has been associated with later visual and nonvisual impairments. Objectives: To evaluate relationships between any stage of ROP, brain volumes, and developmental outcomes. Methods: This study included 52 very preterm infants (gestational age [mean ± SD]: 26.4 ± 1.9 weeks). Total brain, gray matter, unmyelinated white matter (UWMV), and cerebellar volumes were estimated in 51 out of 52 infants by magnetic resonance imaging at term-equivalent age. Bayley Scales of Infant Development were used to assess developmental outcomes in 49 out of 52 infants at a mean corrected age of 24.6 months. Results: Nineteen out of 52 infants developed any stage of ROP. Infants with ROP had a lower median (IQR) UWMV (173 [156–181] vs. 204 [186–216] mL, p < 0.001) and cerebellar volume (18.3 [16.5–20] vs. 22.3 [20.3–24.7] mL, p < 0.001) than infants without ROP. They also had a lower median (IQR) mental developmental index (72 [56–83] vs. 100 [88–104], p < 0.001) and a lower psychomotor developmental index (80 [60–85] vs. 92 [81–103], p = 0.002). Brain volumes and developmental outcomes did not differ among infants with different stages of ROP. Conclusion: Any stage of ROP in preterm infants was associated with a reduced brain volume and an impaired developmental outcome. These results suggest that common pathways may lead to impaired neural and neurovascular development in the brain and retina and that all stages of ROP may be considered in future studies on ROP and development.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Brain volume, Developmental outcome, Magnetic resonance imaging, Mental developmental index, Preterm birth, Psychomotor developmental index, Retinopathy of prematurity
in
Neonatology
volume
114
issue
1
pages
46 - 52
publisher
Karger
external identifiers
  • scopus:85045330481
ISSN
1661-7800
DOI
10.1159/000487847
language
English
LU publication?
yes
id
36fa131a-852b-45bc-ae8f-3fdb2b8eb590
date added to LUP
2018-04-26 15:43:39
date last changed
2019-04-10 04:07:27
@article{36fa131a-852b-45bc-ae8f-3fdb2b8eb590,
  abstract     = {<p>Background: Retinopathy of prematurity (ROP) is a major complication of preterm birth and has been associated with later visual and nonvisual impairments. Objectives: To evaluate relationships between any stage of ROP, brain volumes, and developmental outcomes. Methods: This study included 52 very preterm infants (gestational age [mean ± SD]: 26.4 ± 1.9 weeks). Total brain, gray matter, unmyelinated white matter (UWMV), and cerebellar volumes were estimated in 51 out of 52 infants by magnetic resonance imaging at term-equivalent age. Bayley Scales of Infant Development were used to assess developmental outcomes in 49 out of 52 infants at a mean corrected age of 24.6 months. Results: Nineteen out of 52 infants developed any stage of ROP. Infants with ROP had a lower median (IQR) UWMV (173 [156–181] vs. 204 [186–216] mL, p &lt; 0.001) and cerebellar volume (18.3 [16.5–20] vs. 22.3 [20.3–24.7] mL, p &lt; 0.001) than infants without ROP. They also had a lower median (IQR) mental developmental index (72 [56–83] vs. 100 [88–104], p &lt; 0.001) and a lower psychomotor developmental index (80 [60–85] vs. 92 [81–103], p = 0.002). Brain volumes and developmental outcomes did not differ among infants with different stages of ROP. Conclusion: Any stage of ROP in preterm infants was associated with a reduced brain volume and an impaired developmental outcome. These results suggest that common pathways may lead to impaired neural and neurovascular development in the brain and retina and that all stages of ROP may be considered in future studies on ROP and development.</p>},
  author       = {Sveinsdóttir, Kristbjörg and Ley, David and Hövel, Holger and Fellman, Vineta and Hüppi, Petra S. and Smith, Lois E.H. and Hellström, Ann and Hansen Pupp, Ingrid},
  issn         = {1661-7800},
  keyword      = {Brain volume,Developmental outcome,Magnetic resonance imaging,Mental developmental index,Preterm birth,Psychomotor developmental index,Retinopathy of prematurity},
  language     = {eng},
  month        = {04},
  number       = {1},
  pages        = {46--52},
  publisher    = {Karger},
  series       = {Neonatology},
  title        = {Relation of Retinopathy of Prematurity to Brain Volumes at Term Equivalent Age and Developmental Outcome at 2 Years of Corrected Age in Very Preterm Infants},
  url          = {http://dx.doi.org/10.1159/000487847},
  volume       = {114},
  year         = {2018},
}