Plasma circulating cell-free mitochondrial DNA in social anxiety disorder
(2023) In Psychoneuroendocrinology 148. p.1-5- Abstract
OBJECTIVE: To investigate plasma levels of circulating cell-free mitochondrial DNA (ccf-mtDNA) in patients with social anxiety disorder (SAD) and healthy controls (HC).
METHODS: In this study, 88 participants (46 patients with SAD and 42 HCs) were enrolled and both ccf-mtDNA and peripheral blood mononuclear cells (PBMC) mtDNA copy number (mtDNA-cn) were measured at up to three times per individual (9-11 weeks apart). SAD patients also received cognitive behavioral therapy (CBT) between the second and third time-point.
RESULTS: SAD patients had significantly lower ccf-mtDNA compared to HCs at all time points, but ccf-mtDNA did not change significantly after CBT, and was not associated with severity of anxiety symptoms. Plasma... (More)
OBJECTIVE: To investigate plasma levels of circulating cell-free mitochondrial DNA (ccf-mtDNA) in patients with social anxiety disorder (SAD) and healthy controls (HC).
METHODS: In this study, 88 participants (46 patients with SAD and 42 HCs) were enrolled and both ccf-mtDNA and peripheral blood mononuclear cells (PBMC) mtDNA copy number (mtDNA-cn) were measured at up to three times per individual (9-11 weeks apart). SAD patients also received cognitive behavioral therapy (CBT) between the second and third time-point.
RESULTS: SAD patients had significantly lower ccf-mtDNA compared to HCs at all time points, but ccf-mtDNA did not change significantly after CBT, and was not associated with severity of anxiety symptoms. Plasma ccf-mtDNA did not significantly correlate with PBMC mtDNA-cn in patients.
CONCLUSION: This is the first report of lower ccf-mtDNA in patients with an anxiety disorder. Our findings could reflect a more chronic illness course in SAD patients with prolonged periods of psychological stress leading to decreased levels of ccf-mtDNA, but future longitudinal studies are needed to confirm or refute this hypothesis.
(Less)
- author
- Lindqvist, Daniel LU ; Furmark, Tomas ; Lavebratt, Catharina ; Ohlsson, Lars and Månsson, Kristoffer N T
- organization
- publishing date
- 2023-02
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Psychoneuroendocrinology
- volume
- 148
- article number
- 106001
- pages
- 1 - 5
- publisher
- Elsevier
- external identifiers
-
- pmid:36508952
- scopus:85143981831
- ISSN
- 1873-3360
- DOI
- 10.1016/j.psyneuen.2022.106001
- language
- English
- LU publication?
- yes
- additional info
- Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.
- id
- 36fd7831-6a85-4360-8db9-d2d6e283e54b
- date added to LUP
- 2023-01-09 22:55:25
- date last changed
- 2024-06-13 10:26:26
@article{36fd7831-6a85-4360-8db9-d2d6e283e54b, abstract = {{<p>OBJECTIVE: To investigate plasma levels of circulating cell-free mitochondrial DNA (ccf-mtDNA) in patients with social anxiety disorder (SAD) and healthy controls (HC).</p><p>METHODS: In this study, 88 participants (46 patients with SAD and 42 HCs) were enrolled and both ccf-mtDNA and peripheral blood mononuclear cells (PBMC) mtDNA copy number (mtDNA-cn) were measured at up to three times per individual (9-11 weeks apart). SAD patients also received cognitive behavioral therapy (CBT) between the second and third time-point.</p><p>RESULTS: SAD patients had significantly lower ccf-mtDNA compared to HCs at all time points, but ccf-mtDNA did not change significantly after CBT, and was not associated with severity of anxiety symptoms. Plasma ccf-mtDNA did not significantly correlate with PBMC mtDNA-cn in patients.</p><p>CONCLUSION: This is the first report of lower ccf-mtDNA in patients with an anxiety disorder. Our findings could reflect a more chronic illness course in SAD patients with prolonged periods of psychological stress leading to decreased levels of ccf-mtDNA, but future longitudinal studies are needed to confirm or refute this hypothesis.</p>}}, author = {{Lindqvist, Daniel and Furmark, Tomas and Lavebratt, Catharina and Ohlsson, Lars and Månsson, Kristoffer N T}}, issn = {{1873-3360}}, language = {{eng}}, pages = {{1--5}}, publisher = {{Elsevier}}, series = {{Psychoneuroendocrinology}}, title = {{Plasma circulating cell-free mitochondrial DNA in social anxiety disorder}}, url = {{http://dx.doi.org/10.1016/j.psyneuen.2022.106001}}, doi = {{10.1016/j.psyneuen.2022.106001}}, volume = {{148}}, year = {{2023}}, }