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Plasma circulating cell-free mitochondrial DNA in social anxiety disorder

Lindqvist, Daniel LU ; Furmark, Tomas ; Lavebratt, Catharina ; Ohlsson, Lars and Månsson, Kristoffer N T (2023) In Psychoneuroendocrinology 148. p.1-5
Abstract

OBJECTIVE: To investigate plasma levels of circulating cell-free mitochondrial DNA (ccf-mtDNA) in patients with social anxiety disorder (SAD) and healthy controls (HC).

METHODS: In this study, 88 participants (46 patients with SAD and 42 HCs) were enrolled and both ccf-mtDNA and peripheral blood mononuclear cells (PBMC) mtDNA copy number (mtDNA-cn) were measured at up to three times per individual (9-11 weeks apart). SAD patients also received cognitive behavioral therapy (CBT) between the second and third time-point.

RESULTS: SAD patients had significantly lower ccf-mtDNA compared to HCs at all time points, but ccf-mtDNA did not change significantly after CBT, and was not associated with severity of anxiety symptoms. Plasma... (More)

OBJECTIVE: To investigate plasma levels of circulating cell-free mitochondrial DNA (ccf-mtDNA) in patients with social anxiety disorder (SAD) and healthy controls (HC).

METHODS: In this study, 88 participants (46 patients with SAD and 42 HCs) were enrolled and both ccf-mtDNA and peripheral blood mononuclear cells (PBMC) mtDNA copy number (mtDNA-cn) were measured at up to three times per individual (9-11 weeks apart). SAD patients also received cognitive behavioral therapy (CBT) between the second and third time-point.

RESULTS: SAD patients had significantly lower ccf-mtDNA compared to HCs at all time points, but ccf-mtDNA did not change significantly after CBT, and was not associated with severity of anxiety symptoms. Plasma ccf-mtDNA did not significantly correlate with PBMC mtDNA-cn in patients.

CONCLUSION: This is the first report of lower ccf-mtDNA in patients with an anxiety disorder. Our findings could reflect a more chronic illness course in SAD patients with prolonged periods of psychological stress leading to decreased levels of ccf-mtDNA, but future longitudinal studies are needed to confirm or refute this hypothesis.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Psychoneuroendocrinology
volume
148
article number
106001
pages
1 - 5
publisher
Elsevier
external identifiers
  • pmid:36508952
  • scopus:85143981831
ISSN
1873-3360
DOI
10.1016/j.psyneuen.2022.106001
language
English
LU publication?
yes
additional info
Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.
id
36fd7831-6a85-4360-8db9-d2d6e283e54b
date added to LUP
2023-01-09 22:55:25
date last changed
2024-06-13 10:26:26
@article{36fd7831-6a85-4360-8db9-d2d6e283e54b,
  abstract     = {{<p>OBJECTIVE: To investigate plasma levels of circulating cell-free mitochondrial DNA (ccf-mtDNA) in patients with social anxiety disorder (SAD) and healthy controls (HC).</p><p>METHODS: In this study, 88 participants (46 patients with SAD and 42 HCs) were enrolled and both ccf-mtDNA and peripheral blood mononuclear cells (PBMC) mtDNA copy number (mtDNA-cn) were measured at up to three times per individual (9-11 weeks apart). SAD patients also received cognitive behavioral therapy (CBT) between the second and third time-point.</p><p>RESULTS: SAD patients had significantly lower ccf-mtDNA compared to HCs at all time points, but ccf-mtDNA did not change significantly after CBT, and was not associated with severity of anxiety symptoms. Plasma ccf-mtDNA did not significantly correlate with PBMC mtDNA-cn in patients.</p><p>CONCLUSION: This is the first report of lower ccf-mtDNA in patients with an anxiety disorder. Our findings could reflect a more chronic illness course in SAD patients with prolonged periods of psychological stress leading to decreased levels of ccf-mtDNA, but future longitudinal studies are needed to confirm or refute this hypothesis.</p>}},
  author       = {{Lindqvist, Daniel and Furmark, Tomas and Lavebratt, Catharina and Ohlsson, Lars and Månsson, Kristoffer N T}},
  issn         = {{1873-3360}},
  language     = {{eng}},
  pages        = {{1--5}},
  publisher    = {{Elsevier}},
  series       = {{Psychoneuroendocrinology}},
  title        = {{Plasma circulating cell-free mitochondrial DNA in social anxiety disorder}},
  url          = {{http://dx.doi.org/10.1016/j.psyneuen.2022.106001}},
  doi          = {{10.1016/j.psyneuen.2022.106001}},
  volume       = {{148}},
  year         = {{2023}},
}