LifeGene-a large prospective population-based study of global relevance
(2011) In European Journal of Epidemiology 26(1). p.67-77- Abstract
- Studying gene-environment interactions requires that the amount and quality of the lifestyle data is comparable to what is available for the corresponding genomic data. Sweden has several crucial prerequisites for comprehensive longitudinal biomedical research, such as the personal identity number, the universally available national health care system, continuously updated population and health registries and a scientifically motivated population. LifeGene builds on these strengths to bridge the gap between basic research and clinical applications with particular attention to populations, through a unique design in a research-friendly setting. LifeGene is designed both as a prospective cohort study and an infrastructure with repeated... (More)
- Studying gene-environment interactions requires that the amount and quality of the lifestyle data is comparable to what is available for the corresponding genomic data. Sweden has several crucial prerequisites for comprehensive longitudinal biomedical research, such as the personal identity number, the universally available national health care system, continuously updated population and health registries and a scientifically motivated population. LifeGene builds on these strengths to bridge the gap between basic research and clinical applications with particular attention to populations, through a unique design in a research-friendly setting. LifeGene is designed both as a prospective cohort study and an infrastructure with repeated contacts of study participants approximately every 5 years. Index persons aged 18-45 years old will be recruited and invited to include their household members (partner and any children). A comprehensive questionnaire addressing cutting-edge research questions will be administered through the web with short follow-ups annually. Biosamples and physical measurements will also be collected at baseline, and re-administered every 5 years thereafter. Event-based sampling will be a key feature of LifeGene. The household-based design will give the opportunity to involve young couples prior to and during pregnancy, allowing for the first study of children born into cohort with complete pre-and perinatal data from both the mother and father. Questions and sampling schemes will be tailored to the participants' age and life events. The target of LifeGene is to enrol 500,000 Swedes and follow them longitudinally for at least 20 years. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1790914
- author
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Biobank, Cohort study, Epidemiology, Prospective study, Questionnaires, Population genetics
- in
- European Journal of Epidemiology
- volume
- 26
- issue
- 1
- pages
- 67 - 77
- publisher
- Springer
- external identifiers
-
- wos:000286104700009
- scopus:79151483327
- pmid:21104112
- ISSN
- 1573-7284
- DOI
- 10.1007/s10654-010-9521-x
- language
- English
- LU publication?
- yes
- id
- 3709d5ef-b77f-4950-836a-19d3a094e24a (old id 1790914)
- date added to LUP
- 2016-04-01 11:14:01
- date last changed
- 2024-04-08 02:44:08
@article{3709d5ef-b77f-4950-836a-19d3a094e24a,
abstract = {{Studying gene-environment interactions requires that the amount and quality of the lifestyle data is comparable to what is available for the corresponding genomic data. Sweden has several crucial prerequisites for comprehensive longitudinal biomedical research, such as the personal identity number, the universally available national health care system, continuously updated population and health registries and a scientifically motivated population. LifeGene builds on these strengths to bridge the gap between basic research and clinical applications with particular attention to populations, through a unique design in a research-friendly setting. LifeGene is designed both as a prospective cohort study and an infrastructure with repeated contacts of study participants approximately every 5 years. Index persons aged 18-45 years old will be recruited and invited to include their household members (partner and any children). A comprehensive questionnaire addressing cutting-edge research questions will be administered through the web with short follow-ups annually. Biosamples and physical measurements will also be collected at baseline, and re-administered every 5 years thereafter. Event-based sampling will be a key feature of LifeGene. The household-based design will give the opportunity to involve young couples prior to and during pregnancy, allowing for the first study of children born into cohort with complete pre-and perinatal data from both the mother and father. Questions and sampling schemes will be tailored to the participants' age and life events. The target of LifeGene is to enrol 500,000 Swedes and follow them longitudinally for at least 20 years.}},
author = {{Almqvist, Catarina and Adami, Hans-Olov and Franks, Paul and Groop, Leif and Ingelsson, Erik and Kere, Juha and Lissner, Lauren and Litton, Jan-Eric and Maeurer, Markus and Michaelsson, Karl and Palmgren, Juni and Pershagen, Goran and Ploner, Alexander and Sullivan, Patrick F. and Tybring, Gunnel and Pedersen, Nancy L.}},
issn = {{1573-7284}},
keywords = {{Biobank; Cohort study; Epidemiology; Prospective study; Questionnaires; Population genetics}},
language = {{eng}},
number = {{1}},
pages = {{67--77}},
publisher = {{Springer}},
series = {{European Journal of Epidemiology}},
title = {{LifeGene-a large prospective population-based study of global relevance}},
url = {{http://dx.doi.org/10.1007/s10654-010-9521-x}},
doi = {{10.1007/s10654-010-9521-x}},
volume = {{26}},
year = {{2011}},
}