Preclinical x-ray dark-field radiography for pulmonary emphysema evaluation
(2013) 2013 IEEE 10th International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2013 In Proceedings - International Symposium on Biomedical Imaging p.370-373- Abstract
Pulmonary emphysema is a widespread disorder characterized by irreversible destruction of alveolar walls. The spatial distribution of the disease, so far, could only be obtained using an x-ray CT scan, implying a high patient dose. X-ray scattering on alveolar structures is measured in the dark-field signal. The signal is dependent on the size of alveoli and therefore, a combination of absorption and dark-field signal is explored for mapping the distribution of emphysema in the lung on x-ray projection images. In this study three excised murine lungs with pulmonary emphysema and three control samples were imaged using a compact, cone-beam, small-animal x-ray dark-field scanner with a polychromatic source. Statistical analysis of the... (More)
Pulmonary emphysema is a widespread disorder characterized by irreversible destruction of alveolar walls. The spatial distribution of the disease, so far, could only be obtained using an x-ray CT scan, implying a high patient dose. X-ray scattering on alveolar structures is measured in the dark-field signal. The signal is dependent on the size of alveoli and therefore, a combination of absorption and dark-field signal is explored for mapping the distribution of emphysema in the lung on x-ray projection images. In this study three excised murine lungs with pulmonary emphysema and three control samples were imaged using a compact, cone-beam, small-animal x-ray dark-field scanner with a polychromatic source. Statistical analysis of the results, based on a combination of transmission and dark-field signals, revealed a distinct difference between emphysematous and control samples. Subsequently, the distribution of emphysema was mapped out per-pixel for the lungs and showed good agreement with histological findings.
(Less)
- author
- organization
- publishing date
- 2013
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- dark-field, emphysema, grating interferometer, phase-contrast, x-ray
- host publication
- ISBI 2013 - 2013 IEEE 10th International Symposium on Biomedical Imaging : From Nano to Macro - From Nano to Macro
- series title
- Proceedings - International Symposium on Biomedical Imaging
- pages
- 370 - 373
- conference name
- 2013 IEEE 10th International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2013
- conference location
- San Francisco, CA, United States
- conference dates
- 2013-04-07 - 2013-04-11
- external identifiers
-
- scopus:84881620384
- ISSN
- 1945-8452
- 1945-7928
- ISBN
- 978-1-4673-6456-0
- 978-1-4673-6455-3
- DOI
- 10.1109/ISBI.2013.6556489
- language
- English
- LU publication?
- yes
- id
- 37129f15-7594-4e10-a595-ab46781fcea6
- date added to LUP
- 2022-04-07 11:11:05
- date last changed
- 2024-03-29 01:05:15
@inproceedings{37129f15-7594-4e10-a595-ab46781fcea6, abstract = {{<p>Pulmonary emphysema is a widespread disorder characterized by irreversible destruction of alveolar walls. The spatial distribution of the disease, so far, could only be obtained using an x-ray CT scan, implying a high patient dose. X-ray scattering on alveolar structures is measured in the dark-field signal. The signal is dependent on the size of alveoli and therefore, a combination of absorption and dark-field signal is explored for mapping the distribution of emphysema in the lung on x-ray projection images. In this study three excised murine lungs with pulmonary emphysema and three control samples were imaged using a compact, cone-beam, small-animal x-ray dark-field scanner with a polychromatic source. Statistical analysis of the results, based on a combination of transmission and dark-field signals, revealed a distinct difference between emphysematous and control samples. Subsequently, the distribution of emphysema was mapped out per-pixel for the lungs and showed good agreement with histological findings.</p>}}, author = {{Yaroshenko, A. and Meinel, F. G. and Bech, M. and Tapfer, A. and Velroyen, A. and Schleede, S. and Muller, M. and Auweter, S. and Bohla, A. and Yildirim, A. O. and Nikolaou, K. and Bamberg, F. and Eickelberg, O. and Reiser, M. and Pfeiffer, F.}}, booktitle = {{ISBI 2013 - 2013 IEEE 10th International Symposium on Biomedical Imaging : From Nano to Macro}}, isbn = {{978-1-4673-6456-0}}, issn = {{1945-8452}}, keywords = {{dark-field; emphysema; grating interferometer; phase-contrast; x-ray}}, language = {{eng}}, pages = {{370--373}}, series = {{Proceedings - International Symposium on Biomedical Imaging}}, title = {{Preclinical x-ray dark-field radiography for pulmonary emphysema evaluation}}, url = {{http://dx.doi.org/10.1109/ISBI.2013.6556489}}, doi = {{10.1109/ISBI.2013.6556489}}, year = {{2013}}, }