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Preclinical x-ray dark-field radiography for pulmonary emphysema evaluation

Yaroshenko, A. ; Meinel, F. G. ; Bech, M. LU orcid ; Tapfer, A. ; Velroyen, A. ; Schleede, S. ; Muller, M. ; Auweter, S. ; Bohla, A. and Yildirim, A. O. , et al. (2013) 2013 IEEE 10th International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2013 In Proceedings - International Symposium on Biomedical Imaging p.370-373
Abstract

Pulmonary emphysema is a widespread disorder characterized by irreversible destruction of alveolar walls. The spatial distribution of the disease, so far, could only be obtained using an x-ray CT scan, implying a high patient dose. X-ray scattering on alveolar structures is measured in the dark-field signal. The signal is dependent on the size of alveoli and therefore, a combination of absorption and dark-field signal is explored for mapping the distribution of emphysema in the lung on x-ray projection images. In this study three excised murine lungs with pulmonary emphysema and three control samples were imaged using a compact, cone-beam, small-animal x-ray dark-field scanner with a polychromatic source. Statistical analysis of the... (More)

Pulmonary emphysema is a widespread disorder characterized by irreversible destruction of alveolar walls. The spatial distribution of the disease, so far, could only be obtained using an x-ray CT scan, implying a high patient dose. X-ray scattering on alveolar structures is measured in the dark-field signal. The signal is dependent on the size of alveoli and therefore, a combination of absorption and dark-field signal is explored for mapping the distribution of emphysema in the lung on x-ray projection images. In this study three excised murine lungs with pulmonary emphysema and three control samples were imaged using a compact, cone-beam, small-animal x-ray dark-field scanner with a polychromatic source. Statistical analysis of the results, based on a combination of transmission and dark-field signals, revealed a distinct difference between emphysematous and control samples. Subsequently, the distribution of emphysema was mapped out per-pixel for the lungs and showed good agreement with histological findings.

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organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
dark-field, emphysema, grating interferometer, phase-contrast, x-ray
host publication
ISBI 2013 - 2013 IEEE 10th International Symposium on Biomedical Imaging : From Nano to Macro - From Nano to Macro
series title
Proceedings - International Symposium on Biomedical Imaging
pages
370 - 373
conference name
2013 IEEE 10th International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2013
conference location
San Francisco, CA, United States
conference dates
2013-04-07 - 2013-04-11
external identifiers
  • scopus:84881620384
ISSN
1945-8452
1945-7928
ISBN
978-1-4673-6456-0
978-1-4673-6455-3
DOI
10.1109/ISBI.2013.6556489
language
English
LU publication?
yes
id
37129f15-7594-4e10-a595-ab46781fcea6
date added to LUP
2022-04-07 11:11:05
date last changed
2024-03-29 01:05:15
@inproceedings{37129f15-7594-4e10-a595-ab46781fcea6,
  abstract     = {{<p>Pulmonary emphysema is a widespread disorder characterized by irreversible destruction of alveolar walls. The spatial distribution of the disease, so far, could only be obtained using an x-ray CT scan, implying a high patient dose. X-ray scattering on alveolar structures is measured in the dark-field signal. The signal is dependent on the size of alveoli and therefore, a combination of absorption and dark-field signal is explored for mapping the distribution of emphysema in the lung on x-ray projection images. In this study three excised murine lungs with pulmonary emphysema and three control samples were imaged using a compact, cone-beam, small-animal x-ray dark-field scanner with a polychromatic source. Statistical analysis of the results, based on a combination of transmission and dark-field signals, revealed a distinct difference between emphysematous and control samples. Subsequently, the distribution of emphysema was mapped out per-pixel for the lungs and showed good agreement with histological findings.</p>}},
  author       = {{Yaroshenko, A. and Meinel, F. G. and Bech, M. and Tapfer, A. and Velroyen, A. and Schleede, S. and Muller, M. and Auweter, S. and Bohla, A. and Yildirim, A. O. and Nikolaou, K. and Bamberg, F. and Eickelberg, O. and Reiser, M. and Pfeiffer, F.}},
  booktitle    = {{ISBI 2013 - 2013 IEEE 10th International Symposium on Biomedical Imaging : From Nano to Macro}},
  isbn         = {{978-1-4673-6456-0}},
  issn         = {{1945-8452}},
  keywords     = {{dark-field; emphysema; grating interferometer; phase-contrast; x-ray}},
  language     = {{eng}},
  pages        = {{370--373}},
  series       = {{Proceedings - International Symposium on Biomedical Imaging}},
  title        = {{Preclinical x-ray dark-field radiography for pulmonary emphysema evaluation}},
  url          = {{http://dx.doi.org/10.1109/ISBI.2013.6556489}},
  doi          = {{10.1109/ISBI.2013.6556489}},
  year         = {{2013}},
}