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Circulating Interleukin 17A and Other Inflammatory Proteins May Predict Cardiovascular Disease in Early Rheumatoid Arthritis

Rydell, Emil LU orcid ; Jacobsson, Lennart T.H. and Turesson, Carl LU (2024) In Journal of Rheumatology 51(8). p.752-758
Abstract

Objective. The objective of this study was to investigate the impact of 92 inflammatory proteins on the risk of cardiovascular disease (CVD) in patients with early rheumatoid arthritis (RA). Methods. This study included consecutive patients with early RA recruited between 1995 and 2002. Stored plasma samples were analyzed for 92 inflammatory proteins. CVD diagnoses were retrieved from national in-patient and cause-of-death registries. Statistical analyses were predesignated as hypothesis-driven or exploratory. For the latter, proteins were selected based on principal component analysis (ie, factor loading > 0.5 within main components). Potential predictors of CVD and coronary artery disease (CAD) were assessed using Cox regression.... (More)

Objective. The objective of this study was to investigate the impact of 92 inflammatory proteins on the risk of cardiovascular disease (CVD) in patients with early rheumatoid arthritis (RA). Methods. This study included consecutive patients with early RA recruited between 1995 and 2002. Stored plasma samples were analyzed for 92 inflammatory proteins. CVD diagnoses were retrieved from national in-patient and cause-of-death registries. Statistical analyses were predesignated as hypothesis-driven or exploratory. For the latter, proteins were selected based on principal component analysis (ie, factor loading > 0.5 within main components). Potential predictors of CVD and coronary artery disease (CAD) were assessed using Cox regression. Results. Data on baseline levels of proteins and CVD were available for 163 patients. As hypothesized, levels of interleukin 17A (IL-17A) were associated with CVD (hazard ratio 1.35, 95% CI 1.02-1.78, adjusted for age, sex, hypertension, diabetes, smoking, and erythrocyte sedimentation rate [ESR]), although not significantly with CAD. Osteoprotegerin (OPG) levels were significantly associated with both outcomes, but only in crude models. No associations were observed for IL-6, tumor necrosis factor, monocyte chemotactic protein-1, or IL-8. In the exploratory analyses, MCP-3 in particular had significant associations with both outcomes in crude models. Conclusion. Circulating IL-17A at RA diagnosis predicted future CVD, although we cannot exclude the possibility that this finding is due to multiple testing. The association was independent of traditional CVD risk factors, and of ESR at the time of diagnosis. Further, OPG may be a predictor of CVD. We also identified some novel potential biomarkers for CVD in RA.

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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cardiovascular diseases, interleukin-17, Key Indexing Terms: biomarkers, prognosis, rheumatoid arthritis
in
Journal of Rheumatology
volume
51
issue
8
pages
7 pages
publisher
Journal of Rheumatology Publishing Company Limited
external identifiers
  • pmid:38692670
  • scopus:85200523544
ISSN
0315-162X
DOI
10.3899/jrheum.2023-1078
language
English
LU publication?
yes
id
37166dee-71f3-4b6b-bf6f-0f39f970819e
date added to LUP
2024-09-09 14:19:18
date last changed
2024-09-09 14:20:23
@article{37166dee-71f3-4b6b-bf6f-0f39f970819e,
  abstract     = {{<p>Objective. The objective of this study was to investigate the impact of 92 inflammatory proteins on the risk of cardiovascular disease (CVD) in patients with early rheumatoid arthritis (RA). Methods. This study included consecutive patients with early RA recruited between 1995 and 2002. Stored plasma samples were analyzed for 92 inflammatory proteins. CVD diagnoses were retrieved from national in-patient and cause-of-death registries. Statistical analyses were predesignated as hypothesis-driven or exploratory. For the latter, proteins were selected based on principal component analysis (ie, factor loading &gt; 0.5 within main components). Potential predictors of CVD and coronary artery disease (CAD) were assessed using Cox regression. Results. Data on baseline levels of proteins and CVD were available for 163 patients. As hypothesized, levels of interleukin 17A (IL-17A) were associated with CVD (hazard ratio 1.35, 95% CI 1.02-1.78, adjusted for age, sex, hypertension, diabetes, smoking, and erythrocyte sedimentation rate [ESR]), although not significantly with CAD. Osteoprotegerin (OPG) levels were significantly associated with both outcomes, but only in crude models. No associations were observed for IL-6, tumor necrosis factor, monocyte chemotactic protein-1, or IL-8. In the exploratory analyses, MCP-3 in particular had significant associations with both outcomes in crude models. Conclusion. Circulating IL-17A at RA diagnosis predicted future CVD, although we cannot exclude the possibility that this finding is due to multiple testing. The association was independent of traditional CVD risk factors, and of ESR at the time of diagnosis. Further, OPG may be a predictor of CVD. We also identified some novel potential biomarkers for CVD in RA.</p>}},
  author       = {{Rydell, Emil and Jacobsson, Lennart T.H. and Turesson, Carl}},
  issn         = {{0315-162X}},
  keywords     = {{cardiovascular diseases; interleukin-17; Key Indexing Terms: biomarkers; prognosis; rheumatoid arthritis}},
  language     = {{eng}},
  number       = {{8}},
  pages        = {{752--758}},
  publisher    = {{Journal of Rheumatology Publishing Company Limited}},
  series       = {{Journal of Rheumatology}},
  title        = {{Circulating Interleukin 17A and Other Inflammatory Proteins May Predict Cardiovascular Disease in Early Rheumatoid Arthritis}},
  url          = {{http://dx.doi.org/10.3899/jrheum.2023-1078}},
  doi          = {{10.3899/jrheum.2023-1078}},
  volume       = {{51}},
  year         = {{2024}},
}