Contact sensitization to calocephalin, a sesquiterpene lactone of the guaianolide type from cushion bush (Leucophyta brownii, Compositae)
(2013) In Contact Dermatitis 69(5). p.303-310- Abstract
- BackgroundCushion bush [Leucophyta brownii Cass.=Calocephalus brownii (Cass.) F. Muell.] is an Australian Compositae shrub that has been introduced into Scandinavia as a pot plant. The first case of sensitization occurred in a gardener, and the main allergen was identified as the guaianolide calocephalin. ObjectiveTo present the identification of the main allergen, and to assess the prevalence of sensitization to calocephalin in Compositae-allergic patients. Materials and methodsCalocephalin was isolated from a dichloromethane extract of aerial parts of cushion bush. Calocephalin 0.1% ethanol was included in the plant series in Malmo, Sweden, and Odense, Denmark. ResultsNuclear magnetic resonance (NMR) analysis of calocephalin resulted in... (More)
- BackgroundCushion bush [Leucophyta brownii Cass.=Calocephalus brownii (Cass.) F. Muell.] is an Australian Compositae shrub that has been introduced into Scandinavia as a pot plant. The first case of sensitization occurred in a gardener, and the main allergen was identified as the guaianolide calocephalin. ObjectiveTo present the identification of the main allergen, and to assess the prevalence of sensitization to calocephalin in Compositae-allergic patients. Materials and methodsCalocephalin was isolated from a dichloromethane extract of aerial parts of cushion bush. Calocephalin 0.1% ethanol was included in the plant series in Malmo, Sweden, and Odense, Denmark. ResultsNuclear magnetic resonance (NMR) analysis of calocephalin resulted in a revision of its chemical structure to 4-acetoxy-1,2-epoxy-5,10H-guai-11(13)-en-12,8-olide. The prevalence of patch test positivity was up to 28% in aimed patch testing. Despite strongly positive patch test reactions, the relevance was unknown in the majority of cases, and only 1 person was occupationally sensitized. ConclusionCalocephalin is a potent contact allergen, but, as cushion bush is a low-maintenance pot plant, primary sensitization is most likely to occur through occupational exposure. Positive reactions in Compositae-sensitive persons probably occur because of cross-reactivity, and patients should be warned about contact with cushion bush plants. (Less)
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https://lup.lub.lu.se/record/4160245
- author
- Paulsen, Evy ; Christensen, Lars P. ; Hindsén, Monica LU and Andersen, Klaus E.
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- allergic contact dermatitis, calocephalin, Calocephalus brownii, guaianolides, Leucophyta brownii, occupational, patch testing, sesquiterpene lactones
- in
- Contact Dermatitis
- volume
- 69
- issue
- 5
- pages
- 303 - 310
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000325622400008
- scopus:84885953836
- pmid:23808909
- ISSN
- 0105-1873
- DOI
- 10.1111/cod.12096
- language
- English
- LU publication?
- yes
- id
- 3734476c-bba0-43b1-80d5-c50304ebf960 (old id 4160245)
- date added to LUP
- 2016-04-01 11:16:35
- date last changed
- 2022-06-23 02:42:14
@article{3734476c-bba0-43b1-80d5-c50304ebf960,
abstract = {{BackgroundCushion bush [Leucophyta brownii Cass.=Calocephalus brownii (Cass.) F. Muell.] is an Australian Compositae shrub that has been introduced into Scandinavia as a pot plant. The first case of sensitization occurred in a gardener, and the main allergen was identified as the guaianolide calocephalin. ObjectiveTo present the identification of the main allergen, and to assess the prevalence of sensitization to calocephalin in Compositae-allergic patients. Materials and methodsCalocephalin was isolated from a dichloromethane extract of aerial parts of cushion bush. Calocephalin 0.1% ethanol was included in the plant series in Malmo, Sweden, and Odense, Denmark. ResultsNuclear magnetic resonance (NMR) analysis of calocephalin resulted in a revision of its chemical structure to 4-acetoxy-1,2-epoxy-5,10H-guai-11(13)-en-12,8-olide. The prevalence of patch test positivity was up to 28% in aimed patch testing. Despite strongly positive patch test reactions, the relevance was unknown in the majority of cases, and only 1 person was occupationally sensitized. ConclusionCalocephalin is a potent contact allergen, but, as cushion bush is a low-maintenance pot plant, primary sensitization is most likely to occur through occupational exposure. Positive reactions in Compositae-sensitive persons probably occur because of cross-reactivity, and patients should be warned about contact with cushion bush plants.}},
author = {{Paulsen, Evy and Christensen, Lars P. and Hindsén, Monica and Andersen, Klaus E.}},
issn = {{0105-1873}},
keywords = {{allergic contact dermatitis; calocephalin; Calocephalus brownii; guaianolides; Leucophyta brownii; occupational; patch testing; sesquiterpene lactones}},
language = {{eng}},
number = {{5}},
pages = {{303--310}},
publisher = {{Wiley-Blackwell}},
series = {{Contact Dermatitis}},
title = {{Contact sensitization to calocephalin, a sesquiterpene lactone of the guaianolide type from cushion bush (Leucophyta brownii, Compositae)}},
url = {{http://dx.doi.org/10.1111/cod.12096}},
doi = {{10.1111/cod.12096}},
volume = {{69}},
year = {{2013}},
}