Treating tumoural diseases (cancer) with a
Persson, Bertil R LU
(2011)
In Acta Scientiarum Lundensia
2011(001).
p.1-20
- Abstract
- The aim is to review a patented method and apparatus for treating tumor diseases (cancer)
with a combination of ionizing radiation and pulsed electric fields that might open a new
regime of radiation therapy fractionation with a short intensive treatment with high radiation
dose fractions combined with pulsed electric fields.
Sub-optimal radiation treatment was administered separately or in combination with
electric pulses of field strength (1200 V/cm) to subcutaneous implanted rat brain tumors on
both hind legs. The treatment was repeated four consecutive days and evaluated by recording
tumor growth rate and microscopically examination. Tumors were stained for Factor... (More) - The aim is to review a patented method and apparatus for treating tumor diseases (cancer)
with a combination of ionizing radiation and pulsed electric fields that might open a new
regime of radiation therapy fractionation with a short intensive treatment with high radiation
dose fractions combined with pulsed electric fields.
Sub-optimal radiation treatment was administered separately or in combination with
electric pulses of field strength (1200 V/cm) to subcutaneous implanted rat brain tumors on
both hind legs. The treatment was repeated four consecutive days and evaluated by recording
tumor growth rate and microscopically examination. Tumors were stained for Factor VIII/von
Willebrand Factor to investigate effects on the tumor vasculature and for T-lymphocytes CD4
and CD8 to study their infiltration into the treated tumors.
Radiation and pulsed electric fields applied concomitantly resulted in rapid tumor
regression with significantly (P<0.01 vs. Control) prolonged survival (tumor free >80 days
after treatment) and an average cure rate of 67%. Animals treated with either just radiation or
just Pulsed electric fields showed no significant enhanced survival. Histological and
immunohistochemical examination of tumors treated with RAD and PEF showed instant and
severe deteriorating effects on tumor vasculature and enhanced infiltration of T-lymphocytes. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3737073
- author
- Persson, Bertil R
LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- CD4, CD8, Pulsed electric fields, Radiationtherapy, Rat glioma tumors, Reactive oxygen species (ROS), Tumor vasculature
- in
- Acta Scientiarum Lundensia
- volume
- 2011
- issue
- 001
- pages
- 1 - 20
- publisher
- Bertil RR Persson, Medical Radiation Physics, 22185 Lund, Sweden
- ISSN
- 1651-5013
- language
- English
- LU publication?
- yes
- id
- 76f0cb7d-7cf1-4355-8a40-3e792f0e571a (old id 3737073)
- date added to LUP
- 2016-04-01 13:13:34
- date last changed
- 2025-04-04 15:04:34
@article{76f0cb7d-7cf1-4355-8a40-3e792f0e571a,
abstract = {{The aim is to review a patented method and apparatus for treating tumor diseases (cancer)<br/><br>
with a combination of ionizing radiation and pulsed electric fields that might open a new<br/><br>
regime of radiation therapy fractionation with a short intensive treatment with high radiation<br/><br>
dose fractions combined with pulsed electric fields.<br/><br>
Sub-optimal radiation treatment was administered separately or in combination with<br/><br>
electric pulses of field strength (1200 V/cm) to subcutaneous implanted rat brain tumors on<br/><br>
both hind legs. The treatment was repeated four consecutive days and evaluated by recording<br/><br>
tumor growth rate and microscopically examination. Tumors were stained for Factor VIII/von<br/><br>
Willebrand Factor to investigate effects on the tumor vasculature and for T-lymphocytes CD4<br/><br>
and CD8 to study their infiltration into the treated tumors.<br/><br>
Radiation and pulsed electric fields applied concomitantly resulted in rapid tumor<br/><br>
regression with significantly (P<0.01 vs. Control) prolonged survival (tumor free >80 days<br/><br>
after treatment) and an average cure rate of 67%. Animals treated with either just radiation or<br/><br>
just Pulsed electric fields showed no significant enhanced survival. Histological and<br/><br>
immunohistochemical examination of tumors treated with RAD and PEF showed instant and<br/><br>
severe deteriorating effects on tumor vasculature and enhanced infiltration of T-lymphocytes.}},
author = {{Persson, Bertil R}},
issn = {{1651-5013}},
keywords = {{CD4; CD8; Pulsed electric fields; Radiationtherapy; Rat glioma tumors; Reactive oxygen species (ROS); Tumor vasculature}},
language = {{eng}},
number = {{001}},
pages = {{1--20}},
publisher = {{Bertil RR Persson, Medical Radiation Physics, 22185 Lund, Sweden}},
series = {{Acta Scientiarum Lundensia}},
title = {{Treating tumoural diseases (cancer) with a}},
url = {{https://lup.lub.lu.se/search/files/3238561/3737074.pdf}},
volume = {{2011}},
year = {{2011}},
}