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New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.

Lu, Yingchang ; Day, Felix R ; Gustafsson, Stefan ; Buchkovich, Martin L ; Na, Jianbo ; Bataille, Veronique ; Cousminer, Diana L ; Dastani, Zari ; Drong, Alexander W and Esko, Tõnu , et al. (2016) In Nature Communications 7.
Abstract
To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed... (More)
To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nature Communications
volume
7
article number
10495
publisher
Nature Publishing Group
external identifiers
  • pmid:26833246
  • wos:000371012200002
  • scopus:84965156172
  • pmid:26833246
ISSN
2041-1723
DOI
10.1038/ncomms10495
language
English
LU publication?
yes
id
373b5228-6423-49ed-b4a6-dbff3207561d (old id 8829541)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26833246?dopt=Abstract
date added to LUP
2016-04-04 09:26:18
date last changed
2022-04-08 02:58:46
@article{373b5228-6423-49ed-b4a6-dbff3207561d,
  abstract     = {{To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P&lt;5 × 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.}},
  author       = {{Lu, Yingchang and Day, Felix R and Gustafsson, Stefan and Buchkovich, Martin L and Na, Jianbo and Bataille, Veronique and Cousminer, Diana L and Dastani, Zari and Drong, Alexander W and Esko, Tõnu and Evans, David M and Falchi, Mario and Feitosa, Mary F and Ferreira, Teresa and Hedman, Åsa K and Haring, Robin and Hysi, Pirro G and Iles, Mark M and Justice, Anne E and Kanoni, Stavroula and Lagou, Vasiliki and Li, Rui and Li, Xin and Locke, Adam and Lu, Chen and Mägi, Reedik and Perry, John R B and Pers, Tune H and Qi, Qibin and Sanna, Marianna and Schmidt, Ellen M and Scott, William R and Shungin, Dmitry and Teumer, Alexander and Vinkhuyzen, Anna A E and Walker, Ryan W and Westra, Harm-Jan and Zhang, Mingfeng and Zhang, Weihua and Zhao, Jing Hua and Zhu, Zhihong and Afzal, Uzma and Ahluwalia, Tarunveer Singh and Bakker, Stephan J L and Bellis, Claire and Bonnefond, Amélie and Borodulin, Katja and Buchman, Aron S and Cederholm, Tommy and Choh, Audrey C and Choi, Hyung 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  issn         = {{2041-1723}},
  language     = {{eng}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Nature Communications}},
  title        = {{New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.}},
  url          = {{http://dx.doi.org/10.1038/ncomms10495}},
  doi          = {{10.1038/ncomms10495}},
  volume       = {{7}},
  year         = {{2016}},
}