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The influence of developmental timing on B cell diversity

Kristiansen, Trine A. LU ; Vanhee, Stijn LU and Yuan, Joan LU (2018) In Current Opinion in Immunology 51. p.7-13
Abstract

The adult adaptive immune system is comprised of a wide spectrum of lymphocyte subsets with distinct antigen receptor repertoire profiles, effector functions, turnover times and anatomical locations, acting in concert to provide optimal host protection and self-regulation. While some lymphocyte populations are replenished by bone marrow hematopoietic stem cells (HSCs) through adulthood, others emerge during a limited window of time during fetal and postnatal life and sustain through self-replenishment. Despite fundamental implications in immune regeneration, early life immunity and leukemogenesis, the impact of developmental timing on lymphocyte output remains an under explored frontier in immunology. In this review, we spotlight recent... (More)

The adult adaptive immune system is comprised of a wide spectrum of lymphocyte subsets with distinct antigen receptor repertoire profiles, effector functions, turnover times and anatomical locations, acting in concert to provide optimal host protection and self-regulation. While some lymphocyte populations are replenished by bone marrow hematopoietic stem cells (HSCs) through adulthood, others emerge during a limited window of time during fetal and postnatal life and sustain through self-replenishment. Despite fundamental implications in immune regeneration, early life immunity and leukemogenesis, the impact of developmental timing on lymphocyte output remains an under explored frontier in immunology. In this review, we spotlight recent insights into the developmental changes in B cell output in mice and explore how several age specific cellular and molecular factors may shape the formation of a diverse adaptive immune system.

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author
organization
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type
Contribution to journal
publication status
published
subject
in
Current Opinion in Immunology
volume
51
pages
7 pages
external identifiers
  • scopus:85038884189
ISSN
0952-7915
DOI
10.1016/j.coi.2017.12.005
language
English
LU publication?
yes
id
375b0e01-cfbc-4507-bd77-b3cccb2951f2
date added to LUP
2018-01-03 13:59:38
date last changed
2018-05-29 09:42:53
@article{375b0e01-cfbc-4507-bd77-b3cccb2951f2,
  abstract     = {<p>The adult adaptive immune system is comprised of a wide spectrum of lymphocyte subsets with distinct antigen receptor repertoire profiles, effector functions, turnover times and anatomical locations, acting in concert to provide optimal host protection and self-regulation. While some lymphocyte populations are replenished by bone marrow hematopoietic stem cells (HSCs) through adulthood, others emerge during a limited window of time during fetal and postnatal life and sustain through self-replenishment. Despite fundamental implications in immune regeneration, early life immunity and leukemogenesis, the impact of developmental timing on lymphocyte output remains an under explored frontier in immunology. In this review, we spotlight recent insights into the developmental changes in B cell output in mice and explore how several age specific cellular and molecular factors may shape the formation of a diverse adaptive immune system.</p>},
  author       = {Kristiansen, Trine A. and Vanhee, Stijn and Yuan, Joan},
  issn         = {0952-7915},
  language     = {eng},
  month        = {04},
  pages        = {7--13},
  series       = {Current Opinion in Immunology},
  title        = {The influence of developmental timing on B cell diversity},
  url          = {http://dx.doi.org/10.1016/j.coi.2017.12.005},
  volume       = {51},
  year         = {2018},
}