Antigens for the selection of pan-variable number of tandem repeats motif-specific human antibodies against Mucin-1
Persson, Jonas LU and Ohlin, Mats LU
(2006)
In Journal of Immunological Methods
316(1-2).
p.116-124
- Abstract
- Epitopes found on Mucin-1 are differentially expressed on tumour versus normal tissue. Such epitopes have also been shown to have a potential in immunotherapy and tumour detection. The major epitope explored in this context is located within the variable number of tandem repeats. It has however recently been demonstrated that this epitope exists in several sequence variants. The standard sequence is highly antigenic while the most common sequence variant is much less so. We have now explored routes employing defined synthetic antigens to ensure the development of human recombinant antibody specificities targeting both sequence variants of this epitope. These antibodies may serve as a platform for the development of human antibodies for... (More)
- Epitopes found on Mucin-1 are differentially expressed on tumour versus normal tissue. Such epitopes have also been shown to have a potential in immunotherapy and tumour detection. The major epitope explored in this context is located within the variable number of tandem repeats. It has however recently been demonstrated that this epitope exists in several sequence variants. The standard sequence is highly antigenic while the most common sequence variant is much less so. We have now explored routes employing defined synthetic antigens to ensure the development of human recombinant antibody specificities targeting both sequence variants of this epitope. These antibodies may serve as a platform for the development of human antibodies for efficient targeting of Mucin-1 in human disease. (c) 2006 Elsevier B.V. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/376970
- author
- Persson, Jonas
LU
and Ohlin, Mats
LU
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- tumour-associated antigen, specificity, peptide, antigen, antibody, antibody library
- in
- Journal of Immunological Methods
- volume
- 316
- issue
- 1-2
- pages
- 116 - 124
- publisher
- Elsevier
- external identifiers
-
- wos:000242029600013
- scopus:33750008165
- pmid:17022996
- ISSN
- 1872-7905
- DOI
- 10.1016/j.jim.2006.08.009
- language
- English
- LU publication?
- yes
- id
- 03e28699-71d3-42e4-8102-81880b7d52d5 (old id 376970)
- date added to LUP
- 2016-04-01 16:20:14
- date last changed
- 2022-01-28 19:01:18
@article{03e28699-71d3-42e4-8102-81880b7d52d5,
abstract = {{Epitopes found on Mucin-1 are differentially expressed on tumour versus normal tissue. Such epitopes have also been shown to have a potential in immunotherapy and tumour detection. The major epitope explored in this context is located within the variable number of tandem repeats. It has however recently been demonstrated that this epitope exists in several sequence variants. The standard sequence is highly antigenic while the most common sequence variant is much less so. We have now explored routes employing defined synthetic antigens to ensure the development of human recombinant antibody specificities targeting both sequence variants of this epitope. These antibodies may serve as a platform for the development of human antibodies for efficient targeting of Mucin-1 in human disease. (c) 2006 Elsevier B.V. All rights reserved.}},
author = {{Persson, Jonas and Ohlin, Mats}},
issn = {{1872-7905}},
keywords = {{tumour-associated antigen; specificity; peptide; antigen; antibody; antibody library}},
language = {{eng}},
number = {{1-2}},
pages = {{116--124}},
publisher = {{Elsevier}},
series = {{Journal of Immunological Methods}},
title = {{Antigens for the selection of pan-variable number of tandem repeats motif-specific human antibodies against Mucin-1}},
url = {{http://dx.doi.org/10.1016/j.jim.2006.08.009}},
doi = {{10.1016/j.jim.2006.08.009}},
volume = {{316}},
year = {{2006}},
}