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Antigens for the selection of pan-variable number of tandem repeats motif-specific human antibodies against Mucin-1

Persson, Jonas LU and Ohlin, Mats LU orcid (2006) In Journal of Immunological Methods 316(1-2). p.116-124
Abstract
Epitopes found on Mucin-1 are differentially expressed on tumour versus normal tissue. Such epitopes have also been shown to have a potential in immunotherapy and tumour detection. The major epitope explored in this context is located within the variable number of tandem repeats. It has however recently been demonstrated that this epitope exists in several sequence variants. The standard sequence is highly antigenic while the most common sequence variant is much less so. We have now explored routes employing defined synthetic antigens to ensure the development of human recombinant antibody specificities targeting both sequence variants of this epitope. These antibodies may serve as a platform for the development of human antibodies for... (More)
Epitopes found on Mucin-1 are differentially expressed on tumour versus normal tissue. Such epitopes have also been shown to have a potential in immunotherapy and tumour detection. The major epitope explored in this context is located within the variable number of tandem repeats. It has however recently been demonstrated that this epitope exists in several sequence variants. The standard sequence is highly antigenic while the most common sequence variant is much less so. We have now explored routes employing defined synthetic antigens to ensure the development of human recombinant antibody specificities targeting both sequence variants of this epitope. These antibodies may serve as a platform for the development of human antibodies for efficient targeting of Mucin-1 in human disease. (c) 2006 Elsevier B.V. All rights reserved. (Less)
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author
and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
tumour-associated antigen, specificity, peptide, antigen, antibody, antibody library
in
Journal of Immunological Methods
volume
316
issue
1-2
pages
116 - 124
publisher
Elsevier
external identifiers
  • wos:000242029600013
  • scopus:33750008165
  • pmid:17022996
ISSN
1872-7905
DOI
10.1016/j.jim.2006.08.009
language
English
LU publication?
yes
id
03e28699-71d3-42e4-8102-81880b7d52d5 (old id 376970)
date added to LUP
2016-04-01 16:20:14
date last changed
2021-02-17 02:58:40
@article{03e28699-71d3-42e4-8102-81880b7d52d5,
  abstract     = {Epitopes found on Mucin-1 are differentially expressed on tumour versus normal tissue. Such epitopes have also been shown to have a potential in immunotherapy and tumour detection. The major epitope explored in this context is located within the variable number of tandem repeats. It has however recently been demonstrated that this epitope exists in several sequence variants. The standard sequence is highly antigenic while the most common sequence variant is much less so. We have now explored routes employing defined synthetic antigens to ensure the development of human recombinant antibody specificities targeting both sequence variants of this epitope. These antibodies may serve as a platform for the development of human antibodies for efficient targeting of Mucin-1 in human disease. (c) 2006 Elsevier B.V. All rights reserved.},
  author       = {Persson, Jonas and Ohlin, Mats},
  issn         = {1872-7905},
  language     = {eng},
  number       = {1-2},
  pages        = {116--124},
  publisher    = {Elsevier},
  series       = {Journal of Immunological Methods},
  title        = {Antigens for the selection of pan-variable number of tandem repeats motif-specific human antibodies against Mucin-1},
  url          = {http://dx.doi.org/10.1016/j.jim.2006.08.009},
  doi          = {10.1016/j.jim.2006.08.009},
  volume       = {316},
  year         = {2006},
}