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Nanomedicine’s Role in the COVID-19 Vaccine Development and Optimization

Kumar, Jitendra ; Malhotra, Jaya ; Yadav, Amit Singh LU and Bhati, Anuj Singh (2024) p.39-57
Abstract

Coronavirus disease 2019 (COVID-19) is a contagious disease that turned into a pandemic and led to seven million deaths around the globe. A herculean effort was made by world scientific community to develop various therapies including vaccines against COVID-19 in record time. Use of nanomedicine was one among the different treatment strategies tried against COVID-19. Nanocarriers were effectively used in delivery of vaccines based on live attenuated/inactivated viruses, protein subunits, virus-vectored, Viral-like Particle (VLP), and DNA. Various nanoplatforms such as lipid, polymeric, protein, and cellular vesicle nanoparticles were employed to develop various vaccines against COVID-19. Several novel nanoparticles based on existing... (More)

Coronavirus disease 2019 (COVID-19) is a contagious disease that turned into a pandemic and led to seven million deaths around the globe. A herculean effort was made by world scientific community to develop various therapies including vaccines against COVID-19 in record time. Use of nanomedicine was one among the different treatment strategies tried against COVID-19. Nanocarriers were effectively used in delivery of vaccines based on live attenuated/inactivated viruses, protein subunits, virus-vectored, Viral-like Particle (VLP), and DNA. Various nanoplatforms such as lipid, polymeric, protein, and cellular vesicle nanoparticles were employed to develop various vaccines against COVID-19. Several novel nanoparticles based on existing nanoformulations platforms and certain new nanoparticle preparatory techniques are in pipelines around the world. In the current chapter we have comprehensively discussed the role of nanomedicine in boosting immune response with a special focus on the development and optimization of vaccines against COVID-19.

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Please use this url to cite or link to this publication:
author
; ; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Covid-19, Lipid nanoparticles (LNPs), m-RNA vaccines, Protein nanoparticles (PNPs), SARS-CoV-2
host publication
Nanotechnology in the Life Sciences
pages
19 pages
publisher
Springer Science and Business Media B.V.
external identifiers
  • scopus:85212268417
DOI
10.1007/978-3-031-72467-1_3
language
English
LU publication?
yes
id
376ef959-9802-4c0b-b3b5-5737bc7b37f5
date added to LUP
2025-01-27 12:18:01
date last changed
2025-04-04 15:01:51
@inbook{376ef959-9802-4c0b-b3b5-5737bc7b37f5,
  abstract     = {{<p>Coronavirus disease 2019 (COVID-19) is a contagious disease that turned into a pandemic and led to seven million deaths around the globe. A herculean effort was made by world scientific community to develop various therapies including vaccines against COVID-19 in record time. Use of nanomedicine was one among the different treatment strategies tried against COVID-19. Nanocarriers were effectively used in delivery of vaccines based on live attenuated/inactivated viruses, protein subunits, virus-vectored, Viral-like Particle (VLP), and DNA. Various nanoplatforms such as lipid, polymeric, protein, and cellular vesicle nanoparticles were employed to develop various vaccines against COVID-19. Several novel nanoparticles based on existing nanoformulations platforms and certain new nanoparticle preparatory techniques are in pipelines around the world. In the current chapter we have comprehensively discussed the role of nanomedicine in boosting immune response with a special focus on the development and optimization of vaccines against COVID-19.</p>}},
  author       = {{Kumar, Jitendra and Malhotra, Jaya and Yadav, Amit Singh and Bhati, Anuj Singh}},
  booktitle    = {{Nanotechnology in the Life Sciences}},
  keywords     = {{Covid-19; Lipid nanoparticles (LNPs); m-RNA vaccines; Protein nanoparticles (PNPs); SARS-CoV-2}},
  language     = {{eng}},
  pages        = {{39--57}},
  publisher    = {{Springer Science and Business Media B.V.}},
  title        = {{Nanomedicine’s Role in the COVID-19 Vaccine Development and Optimization}},
  url          = {{http://dx.doi.org/10.1007/978-3-031-72467-1_3}},
  doi          = {{10.1007/978-3-031-72467-1_3}},
  year         = {{2024}},
}