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Oral lichenoid lesions in two snuff users with contact allergy to carvone

Adwa, Usamah ; Antelmi, Annarita LU ; Sukakul, Thanisorn LU orcid ; Dahlin, Jakob LU ; Bruze, Magnus LU and Svedman, Cecilia LU (2024) In Contact Dermatitis 90(1). p.74-78
Abstract

BACKGROUND: Contact allergy to the mint-tasting flavour carvone has been observed in patients with oral lichenoid lesions (OLL). Mint-flavoured products such as toothpaste frequently contain carvone. Snuff is a smokeless tobacco product that is chewed or placed in the mouth rather than smoked. In Sweden, the use of snuff and its flavoured versions is extremely common.

OBJECTIVES: To investigate whether the consumption of mint-flavoured snuff is associated with contact allergy to carvone and subsequently plays a role in the aetiology of OLL.

METHODS: Regarding the two patients, patch testing with snuff pouches was performed. High-performance liquid chromatography and gas chromatography-mass spectrometry analysis were used for... (More)

BACKGROUND: Contact allergy to the mint-tasting flavour carvone has been observed in patients with oral lichenoid lesions (OLL). Mint-flavoured products such as toothpaste frequently contain carvone. Snuff is a smokeless tobacco product that is chewed or placed in the mouth rather than smoked. In Sweden, the use of snuff and its flavoured versions is extremely common.

OBJECTIVES: To investigate whether the consumption of mint-flavoured snuff is associated with contact allergy to carvone and subsequently plays a role in the aetiology of OLL.

METHODS: Regarding the two patients, patch testing with snuff pouches was performed. High-performance liquid chromatography and gas chromatography-mass spectrometry analysis were used for identification of carvone in different snuff samples.

RESULTS: Two patients with OLL were contacted allergic to carvone when patch tested. Both were using mint-flavoured snuffs several hours a day for many years. One patient was contacted allergic to the snuff pouch tested as is. Carvone was detected in the snuff samples of both patients.

CONCLUSIONS: The patients were recommended to avoid the use of mint-flavoured snuffs, toothpaste and foodstuffs. At follow-up 3 months later, the patients had a dramatic clinical improvement of the OLL and oral symptoms. Exposure to mint-flavoured snuffs can be overlooked as a possible aggravating/provoking factor in OLL.

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Please use this url to cite or link to this publication:
author
; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
subject
in
Contact Dermatitis
volume
90
issue
1
pages
74 - 78
publisher
Wiley-Blackwell
external identifiers
  • pmid:37915267
  • scopus:85175609621
ISSN
0105-1873
DOI
10.1111/cod.14448
language
English
LU publication?
no
additional info
© 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
id
37b776fd-c2c3-416a-b46c-ad31ae96faa1
date added to LUP
2023-11-20 09:27:52
date last changed
2025-10-18 11:21:42
@article{37b776fd-c2c3-416a-b46c-ad31ae96faa1,
  abstract     = {{<p>BACKGROUND: Contact allergy to the mint-tasting flavour carvone has been observed in patients with oral lichenoid lesions (OLL). Mint-flavoured products such as toothpaste frequently contain carvone. Snuff is a smokeless tobacco product that is chewed or placed in the mouth rather than smoked. In Sweden, the use of snuff and its flavoured versions is extremely common.</p><p>OBJECTIVES: To investigate whether the consumption of mint-flavoured snuff is associated with contact allergy to carvone and subsequently plays a role in the aetiology of OLL.</p><p>METHODS: Regarding the two patients, patch testing with snuff pouches was performed. High-performance liquid chromatography and gas chromatography-mass spectrometry analysis were used for identification of carvone in different snuff samples.</p><p>RESULTS: Two patients with OLL were contacted allergic to carvone when patch tested. Both were using mint-flavoured snuffs several hours a day for many years. One patient was contacted allergic to the snuff pouch tested as is. Carvone was detected in the snuff samples of both patients.</p><p>CONCLUSIONS: The patients were recommended to avoid the use of mint-flavoured snuffs, toothpaste and foodstuffs. At follow-up 3 months later, the patients had a dramatic clinical improvement of the OLL and oral symptoms. Exposure to mint-flavoured snuffs can be overlooked as a possible aggravating/provoking factor in OLL.</p>}},
  author       = {{Adwa, Usamah and Antelmi, Annarita and Sukakul, Thanisorn and Dahlin, Jakob and Bruze, Magnus and Svedman, Cecilia}},
  issn         = {{0105-1873}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{74--78}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Contact Dermatitis}},
  title        = {{Oral lichenoid lesions in two snuff users with contact allergy to carvone}},
  url          = {{http://dx.doi.org/10.1111/cod.14448}},
  doi          = {{10.1111/cod.14448}},
  volume       = {{90}},
  year         = {{2024}},
}