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Introduction to stem cell biology and its role in treating neurologic disorders

Parmar, Malin LU orcid and Perrier, Anselme L. (2024) In Handbook of Clinical Neurology 205. p.3-14
Abstract

Regenerative medicine is an emerging and rapidly evolving field of research and therapeutics aimed to restore, maintain, and improve body functions. In the adult mammalian brain, very few neurons, if any, are generated after disease onset or an injury, and its ability to self-repair is therefore limited. Replacing neurons that are lost during neurodegenerative diseases or due to injury therefore represents one of the major challenges to modern medicine. In this introductory chapter, we describe the basic biology of stem cells and outline how stem cells and cell reprogramming can be utilized to create new neurons for therapeutic purposes that are discussed in detail in other chapters in this handbook.

Please use this url to cite or link to this publication:
author
and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Embryonic stem cells, Induced pluripotent stem cells, Pluripotent stem cells, Tissue-specific stem cells
host publication
Cell and Gene Therapies for Neurologic Diseases
series title
Handbook of Clinical Neurology
editor
Federoff, Howard J. and Barker, Roger A.
volume
205
pages
12 pages
publisher
Elsevier Science Publishers B.V.
external identifiers
  • scopus:85204787723
  • pmid:39341661
ISSN
2212-4152
0072-9752
ISBN
978-0-323-90120-8
DOI
10.1016/B978-0-323-90120-8.00005-8
language
English
LU publication?
yes
id
37bdc130-a6d1-4226-ac7f-06ca2c7e10fe
date added to LUP
2024-11-26 14:54:52
date last changed
2025-07-09 09:34:26
@inbook{37bdc130-a6d1-4226-ac7f-06ca2c7e10fe,
  abstract     = {{<p>Regenerative medicine is an emerging and rapidly evolving field of research and therapeutics aimed to restore, maintain, and improve body functions. In the adult mammalian brain, very few neurons, if any, are generated after disease onset or an injury, and its ability to self-repair is therefore limited. Replacing neurons that are lost during neurodegenerative diseases or due to injury therefore represents one of the major challenges to modern medicine. In this introductory chapter, we describe the basic biology of stem cells and outline how stem cells and cell reprogramming can be utilized to create new neurons for therapeutic purposes that are discussed in detail in other chapters in this handbook.</p>}},
  author       = {{Parmar, Malin and Perrier, Anselme L.}},
  booktitle    = {{Cell and Gene Therapies for Neurologic Diseases}},
  editor       = {{Federoff, Howard J. and Barker, Roger A.}},
  isbn         = {{978-0-323-90120-8}},
  issn         = {{2212-4152}},
  keywords     = {{Embryonic stem cells; Induced pluripotent stem cells; Pluripotent stem cells; Tissue-specific stem cells}},
  language     = {{eng}},
  pages        = {{3--14}},
  publisher    = {{Elsevier Science Publishers B.V.}},
  series       = {{Handbook of Clinical Neurology}},
  title        = {{Introduction to stem cell biology and its role in treating neurologic disorders}},
  url          = {{http://dx.doi.org/10.1016/B978-0-323-90120-8.00005-8}},
  doi          = {{10.1016/B978-0-323-90120-8.00005-8}},
  volume       = {{205}},
  year         = {{2024}},
}