Platelets in ITP : Victims in charge of their own fate?
(2021) In Cells 10(11).- Abstract
Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder. The pathophysiological mechanisms leading to low platelet levels in ITP have not been resolved, but at least involve autoantibody-dependent and/or cytotoxic T cell mediated platelet clearance and impaired megakary-opoiesis. In addition, T cell imbalances involving T regulatory cells (Tregs) also appear to play an important role. Intriguingly, over the past years it has become evident that platelets not only mediate hemostasis, but are able to modulate inflammatory and immunological processes upon activation. Platelets, therefore, might play an immuno-modulatory role in the pathogenesis and pathophysiology of ITP. In this respect, we propose several possible pathways in... (More)
Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder. The pathophysiological mechanisms leading to low platelet levels in ITP have not been resolved, but at least involve autoantibody-dependent and/or cytotoxic T cell mediated platelet clearance and impaired megakary-opoiesis. In addition, T cell imbalances involving T regulatory cells (Tregs) also appear to play an important role. Intriguingly, over the past years it has become evident that platelets not only mediate hemostasis, but are able to modulate inflammatory and immunological processes upon activation. Platelets, therefore, might play an immuno-modulatory role in the pathogenesis and pathophysiology of ITP. In this respect, we propose several possible pathways in which platelets themselves may participate in the immune response in ITP. First, we will elaborate on how platelets might directly promote inflammation or stimulate immune responses in ITP. Second, we will discuss two ways in which platelet microparticles (PMPs) might contribute to the disrupted immune balance and impaired thrombopoiesis by megakaryocytes in ITP. Importantly, from these insights, new starting points for further research and for the design of potential future therapies for ITP can be envisioned.
(Less)
- author
- Nelson, Vivianne S. ; Jolink, Anne Tess C. ; Amini, Sufia N. ; Zwaginga, Jaap Jan ; Netelenbos, Tanja ; Semple, John W. LU ; Porcelijn, Leendert ; de Haas, Masja ; Schipperus, Martin R. and Kapur, Rick LU
- organization
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- ITP, Platelet immune functions, Platelet microparticles
- in
- Cells
- volume
- 10
- issue
- 11
- article number
- 3235
- publisher
- MDPI AG
- external identifiers
-
- scopus:85119248646
- pmid:34831457
- ISSN
- 2073-4409
- DOI
- 10.3390/cells10113235
- language
- English
- LU publication?
- yes
- id
- 37e23db7-ccac-4f85-86a6-090c8aad1f67
- date added to LUP
- 2021-12-03 13:45:13
- date last changed
- 2025-02-09 21:52:46
@article{37e23db7-ccac-4f85-86a6-090c8aad1f67, abstract = {{<p>Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder. The pathophysiological mechanisms leading to low platelet levels in ITP have not been resolved, but at least involve autoantibody-dependent and/or cytotoxic T cell mediated platelet clearance and impaired megakary-opoiesis. In addition, T cell imbalances involving T regulatory cells (Tregs) also appear to play an important role. Intriguingly, over the past years it has become evident that platelets not only mediate hemostasis, but are able to modulate inflammatory and immunological processes upon activation. Platelets, therefore, might play an immuno-modulatory role in the pathogenesis and pathophysiology of ITP. In this respect, we propose several possible pathways in which platelets themselves may participate in the immune response in ITP. First, we will elaborate on how platelets might directly promote inflammation or stimulate immune responses in ITP. Second, we will discuss two ways in which platelet microparticles (PMPs) might contribute to the disrupted immune balance and impaired thrombopoiesis by megakaryocytes in ITP. Importantly, from these insights, new starting points for further research and for the design of potential future therapies for ITP can be envisioned.</p>}}, author = {{Nelson, Vivianne S. and Jolink, Anne Tess C. and Amini, Sufia N. and Zwaginga, Jaap Jan and Netelenbos, Tanja and Semple, John W. and Porcelijn, Leendert and de Haas, Masja and Schipperus, Martin R. and Kapur, Rick}}, issn = {{2073-4409}}, keywords = {{ITP; Platelet immune functions; Platelet microparticles}}, language = {{eng}}, number = {{11}}, publisher = {{MDPI AG}}, series = {{Cells}}, title = {{Platelets in ITP : Victims in charge of their own fate?}}, url = {{http://dx.doi.org/10.3390/cells10113235}}, doi = {{10.3390/cells10113235}}, volume = {{10}}, year = {{2021}}, }