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Platelets in ITP : Victims in charge of their own fate?

Nelson, Vivianne S. ; Jolink, Anne Tess C. ; Amini, Sufia N. ; Zwaginga, Jaap Jan ; Netelenbos, Tanja ; Semple, John W. LU ; Porcelijn, Leendert ; de Haas, Masja ; Schipperus, Martin R. and Kapur, Rick LU (2021) In Cells 10(11).
Abstract

Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder. The pathophysiological mechanisms leading to low platelet levels in ITP have not been resolved, but at least involve autoantibody-dependent and/or cytotoxic T cell mediated platelet clearance and impaired megakary-opoiesis. In addition, T cell imbalances involving T regulatory cells (Tregs) also appear to play an important role. Intriguingly, over the past years it has become evident that platelets not only mediate hemostasis, but are able to modulate inflammatory and immunological processes upon activation. Platelets, therefore, might play an immuno-modulatory role in the pathogenesis and pathophysiology of ITP. In this respect, we propose several possible pathways in... (More)

Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder. The pathophysiological mechanisms leading to low platelet levels in ITP have not been resolved, but at least involve autoantibody-dependent and/or cytotoxic T cell mediated platelet clearance and impaired megakary-opoiesis. In addition, T cell imbalances involving T regulatory cells (Tregs) also appear to play an important role. Intriguingly, over the past years it has become evident that platelets not only mediate hemostasis, but are able to modulate inflammatory and immunological processes upon activation. Platelets, therefore, might play an immuno-modulatory role in the pathogenesis and pathophysiology of ITP. In this respect, we propose several possible pathways in which platelets themselves may participate in the immune response in ITP. First, we will elaborate on how platelets might directly promote inflammation or stimulate immune responses in ITP. Second, we will discuss two ways in which platelet microparticles (PMPs) might contribute to the disrupted immune balance and impaired thrombopoiesis by megakaryocytes in ITP. Importantly, from these insights, new starting points for further research and for the design of potential future therapies for ITP can be envisioned.

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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
ITP, Platelet immune functions, Platelet microparticles
in
Cells
volume
10
issue
11
article number
3235
publisher
MDPI AG
external identifiers
  • pmid:34831457
  • scopus:85119248646
ISSN
2073-4409
DOI
10.3390/cells10113235
language
English
LU publication?
yes
id
37e23db7-ccac-4f85-86a6-090c8aad1f67
date added to LUP
2021-12-03 13:45:13
date last changed
2024-06-15 22:03:10
@article{37e23db7-ccac-4f85-86a6-090c8aad1f67,
  abstract     = {{<p>Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder. The pathophysiological mechanisms leading to low platelet levels in ITP have not been resolved, but at least involve autoantibody-dependent and/or cytotoxic T cell mediated platelet clearance and impaired megakary-opoiesis. In addition, T cell imbalances involving T regulatory cells (Tregs) also appear to play an important role. Intriguingly, over the past years it has become evident that platelets not only mediate hemostasis, but are able to modulate inflammatory and immunological processes upon activation. Platelets, therefore, might play an immuno-modulatory role in the pathogenesis and pathophysiology of ITP. In this respect, we propose several possible pathways in which platelets themselves may participate in the immune response in ITP. First, we will elaborate on how platelets might directly promote inflammation or stimulate immune responses in ITP. Second, we will discuss two ways in which platelet microparticles (PMPs) might contribute to the disrupted immune balance and impaired thrombopoiesis by megakaryocytes in ITP. Importantly, from these insights, new starting points for further research and for the design of potential future therapies for ITP can be envisioned.</p>}},
  author       = {{Nelson, Vivianne S. and Jolink, Anne Tess C. and Amini, Sufia N. and Zwaginga, Jaap Jan and Netelenbos, Tanja and Semple, John W. and Porcelijn, Leendert and de Haas, Masja and Schipperus, Martin R. and Kapur, Rick}},
  issn         = {{2073-4409}},
  keywords     = {{ITP; Platelet immune functions; Platelet microparticles}},
  language     = {{eng}},
  number       = {{11}},
  publisher    = {{MDPI AG}},
  series       = {{Cells}},
  title        = {{Platelets in ITP : Victims in charge of their own fate?}},
  url          = {{http://dx.doi.org/10.3390/cells10113235}},
  doi          = {{10.3390/cells10113235}},
  volume       = {{10}},
  year         = {{2021}},
}