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Hepatic lymph nodes as a follow-up factor in primary biliary cirrhosis : An ultrasound study

Lyttkens, K. LU ; Prytz, H. LU ; Forsberg, L. and Hägerstrand, I. (1995) In Scandinavian Journal of Gastroenterology 30(10). p.1036-1040
Abstract

Background: The aim of this study was to investigate whether changes in lymph node size in the hepatoduodenal ligament reflect changes in biochemical and histologic markers of cholestasis, hepatocellular damage, and humoral immunoreactivity in patients with primary biliary cirrhosis (PBC). Methods: Twenty-three consecutive patients were examined with repeated liver biopsies, laboratory tests, and ultrasonographic examinations of the hepatoduodenal ligament. The effect of treatment with ursodeoxycholic acid (UDCA) on these factors was also studied. Results: A correlation was found between changes in lymph node size and changes in markers of hepatocellular damage, cholestasis, and humoral immunoreactivity and also with intralobular... (More)

Background: The aim of this study was to investigate whether changes in lymph node size in the hepatoduodenal ligament reflect changes in biochemical and histologic markers of cholestasis, hepatocellular damage, and humoral immunoreactivity in patients with primary biliary cirrhosis (PBC). Methods: Twenty-three consecutive patients were examined with repeated liver biopsies, laboratory tests, and ultrasonographic examinations of the hepatoduodenal ligament. The effect of treatment with ursodeoxycholic acid (UDCA) on these factors was also studied. Results: A correlation was found between changes in lymph node size and changes in markers of hepatocellular damage, cholestasis, and humoral immunoreactivity and also with intralobular inflammation. In the UDCA-treated patients the node size decreased slightly during 2 years of treatment, whereas it was unchanged in the control group (p = 0.0528). Conclusions: Changes in the size of the lymph nodes in the hepatoduodenal ligament may reflect inflammation and cholestasis in PBC and thus be a valuable indicator in the follow-up of patients with this disease.

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author
; ; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cholestasis, Hepatocellular damage, Humoral immunoreactivity, Intralobular inflammation, Ursodeoxycholic acid
in
Scandinavian Journal of Gastroenterology
volume
30
issue
10
pages
5 pages
publisher
Taylor & Francis
external identifiers
  • pmid:8545610
  • scopus:0028865315
ISSN
0036-5521
DOI
10.3109/00365529509096350
language
English
LU publication?
no
id
37ebd797-13ec-4f4a-ac21-3ea020af2cdc
date added to LUP
2019-05-28 22:18:07
date last changed
2021-01-03 05:09:06
@article{37ebd797-13ec-4f4a-ac21-3ea020af2cdc,
  abstract     = {<p>Background: The aim of this study was to investigate whether changes in lymph node size in the hepatoduodenal ligament reflect changes in biochemical and histologic markers of cholestasis, hepatocellular damage, and humoral immunoreactivity in patients with primary biliary cirrhosis (PBC). Methods: Twenty-three consecutive patients were examined with repeated liver biopsies, laboratory tests, and ultrasonographic examinations of the hepatoduodenal ligament. The effect of treatment with ursodeoxycholic acid (UDCA) on these factors was also studied. Results: A correlation was found between changes in lymph node size and changes in markers of hepatocellular damage, cholestasis, and humoral immunoreactivity and also with intralobular inflammation. In the UDCA-treated patients the node size decreased slightly during 2 years of treatment, whereas it was unchanged in the control group (p = 0.0528). Conclusions: Changes in the size of the lymph nodes in the hepatoduodenal ligament may reflect inflammation and cholestasis in PBC and thus be a valuable indicator in the follow-up of patients with this disease.</p>},
  author       = {Lyttkens, K. and Prytz, H. and Forsberg, L. and Hägerstrand, I.},
  issn         = {0036-5521},
  language     = {eng},
  month        = {01},
  number       = {10},
  pages        = {1036--1040},
  publisher    = {Taylor & Francis},
  series       = {Scandinavian Journal of Gastroenterology},
  title        = {Hepatic lymph nodes as a follow-up factor in primary biliary cirrhosis : An ultrasound study},
  url          = {http://dx.doi.org/10.3109/00365529509096350},
  doi          = {10.3109/00365529509096350},
  volume       = {30},
  year         = {1995},
}