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Microphthalmia-associated transcription factor-dependent melanoma cell adhesion molecule activation promotes peritoneal metastasis of ovarian cancer

Kitami, Kazuhisa ; Yoshihara, Masato ; Koya, Yoshihiro ; Sugiyama, Mai ; Iyoshi, Shohei ; Uno, Kaname LU orcid ; Mogi, Kazumasa ; Tano, Sho ; Fujimoto, Hiroki and Nawa, Akihiro , et al. (2020) In International Journal of Molecular Sciences 21(24).
Abstract

Ovarian cancer (OvCa) is one of the leading causes of death due to its high metastasis rate to the peritoneum. Recurrent peritoneal tumors also develop despite the use of conventional platinum-based chemotherapies. Therefore, it is still important to explore the factors associated with peritoneal metastasis, as these predict the prognosis of patients with OvCa. In this study, we investigated the function of microphthalmia-associated transcription factor (MITF), which contributes to the development of melanoma, in epithelial ovarian cancer (OvCa). High MITF expression was significantly associated with a poor prognosis in OvCa. Notably, MITF contributed to the motility and invasion of OvCa cells, and specifically with their... (More)

Ovarian cancer (OvCa) is one of the leading causes of death due to its high metastasis rate to the peritoneum. Recurrent peritoneal tumors also develop despite the use of conventional platinum-based chemotherapies. Therefore, it is still important to explore the factors associated with peritoneal metastasis, as these predict the prognosis of patients with OvCa. In this study, we investigated the function of microphthalmia-associated transcription factor (MITF), which contributes to the development of melanoma, in epithelial ovarian cancer (OvCa). High MITF expression was significantly associated with a poor prognosis in OvCa. Notably, MITF contributed to the motility and invasion of OvCa cells, and specifically with their peri-mesothelial migration. In addition, MITF-positive cells expressed the melanoma cell adhesion molecule (MCAM/CD146), which was initially identified as a marker of melanoma progression and metastasis, and MCAM expression was regulated by MITF. MCAM was also identified as a significant prognostic factor for poor progression-free survival in patients with OvCa. Collectively, our results suggest that MITF is a novel therapeutic target that potentially promotes peritoneal metastasis of OvCa.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
CD146, EMT, Invasion, MCAM, Mesothelial, Metastasis, Migration, MITF, Ovarian cancer
in
International Journal of Molecular Sciences
volume
21
issue
24
article number
9776
pages
15 pages
publisher
MDPI AG
external identifiers
  • pmid:33371469
  • scopus:85098328629
ISSN
1661-6596
DOI
10.3390/ijms21249776
language
English
LU publication?
yes
id
37eed07d-8665-4e11-b65d-c3ce05df1d80
date added to LUP
2021-01-05 14:28:32
date last changed
2024-05-16 01:55:35
@article{37eed07d-8665-4e11-b65d-c3ce05df1d80,
  abstract     = {{<p>Ovarian cancer (OvCa) is one of the leading causes of death due to its high metastasis rate to the peritoneum. Recurrent peritoneal tumors also develop despite the use of conventional platinum-based chemotherapies. Therefore, it is still important to explore the factors associated with peritoneal metastasis, as these predict the prognosis of patients with OvCa. In this study, we investigated the function of microphthalmia-associated transcription factor (MITF), which contributes to the development of melanoma, in epithelial ovarian cancer (OvCa). High MITF expression was significantly associated with a poor prognosis in OvCa. Notably, MITF contributed to the motility and invasion of OvCa cells, and specifically with their peri-mesothelial migration. In addition, MITF-positive cells expressed the melanoma cell adhesion molecule (MCAM/CD146), which was initially identified as a marker of melanoma progression and metastasis, and MCAM expression was regulated by MITF. MCAM was also identified as a significant prognostic factor for poor progression-free survival in patients with OvCa. Collectively, our results suggest that MITF is a novel therapeutic target that potentially promotes peritoneal metastasis of OvCa.</p>}},
  author       = {{Kitami, Kazuhisa and Yoshihara, Masato and Koya, Yoshihiro and Sugiyama, Mai and Iyoshi, Shohei and Uno, Kaname and Mogi, Kazumasa and Tano, Sho and Fujimoto, Hiroki and Nawa, Akihiro and Kikkawa, Fumitaka and Kajiyama, Hiroaki}},
  issn         = {{1661-6596}},
  keywords     = {{CD146; EMT; Invasion; MCAM; Mesothelial; Metastasis; Migration; MITF; Ovarian cancer}},
  language     = {{eng}},
  month        = {{12}},
  number       = {{24}},
  publisher    = {{MDPI AG}},
  series       = {{International Journal of Molecular Sciences}},
  title        = {{Microphthalmia-associated transcription factor-dependent melanoma cell adhesion molecule activation promotes peritoneal metastasis of ovarian cancer}},
  url          = {{http://dx.doi.org/10.3390/ijms21249776}},
  doi          = {{10.3390/ijms21249776}},
  volume       = {{21}},
  year         = {{2020}},
}