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The relationship between the metabolic syndrome and arterial wall thickness : A mosaic still to be interpreted

Scuteri, Angelo; Franco, Oscar H.; Völzke, Henry; Shin, Min Ho; Kweon, Sun Seog; Rietzschel, Ernst; Ryliškytė, Ligita; Strazhesko, Irina; Chen, Chen Huan and Lakatta, Edward G., et al. (2016) In Atherosclerosis 255. p.11-16
Abstract

Background and aims We aimed to identify clusters of metabolic syndrome (MetS) components, risky for extremely high intima-media thickness. Methods We studied 41,513 volunteers (men and women) from eleven cohorts worldwide, participating in the MARE (Metabolic syndrome and Artery REsearch) Consortium. Results Specific clusters of MetS components - high triglycerides-high blood pressure-abdominal obesity (TBW), low HDL cholesterol-high blood pressure-abdominal obesity (HBW), high glucose-high blood pressure-abdominal obesity (GBW) - were accompanied by a 50–90% significantly greater likelihood of presenting extremely high intima-media thickness (via ultrasound of carotid artery, CCA IMT), after controlling for age, sex, smoking, non-HDL... (More)

Background and aims We aimed to identify clusters of metabolic syndrome (MetS) components, risky for extremely high intima-media thickness. Methods We studied 41,513 volunteers (men and women) from eleven cohorts worldwide, participating in the MARE (Metabolic syndrome and Artery REsearch) Consortium. Results Specific clusters of MetS components - high triglycerides-high blood pressure-abdominal obesity (TBW), low HDL cholesterol-high blood pressure-abdominal obesity (HBW), high glucose-high blood pressure-abdominal obesity (GBW) - were accompanied by a 50–90% significantly greater likelihood of presenting extremely high intima-media thickness (via ultrasound of carotid artery, CCA IMT), after controlling for age, sex, smoking, non-HDL cholesterol, and presence of diabetes mellitus. This likelihood is comparable to the effect of being 7–8 years older or of being a cigarette smoker or of having non-HDL cholesterol 50 mg/dl higher. Conclusions The consistent association of specific clusters of MetS components with extremely thick (older) large artery cross-culturally suggests that identification of those clusters in clinical practice will facilitate a personalized health care and a better – i.e. more healthy and cost-effective - prevention of major cardiovascular (CV) events.

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publication status
published
subject
keywords
Arterial ageing, Arteries, Carotid intima-media thickness, Metabolic syndrome
in
Atherosclerosis
volume
255
pages
6 pages
publisher
Elsevier
external identifiers
  • scopus:84994017997
  • wos:000389509700026
ISSN
0021-9150
DOI
10.1016/j.atherosclerosis.2016.10.032
language
English
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yes
id
37f98723-a4aa-4977-b3e1-cffb1c3e2ef6
date added to LUP
2016-11-18 14:01:16
date last changed
2017-09-18 11:30:47
@article{37f98723-a4aa-4977-b3e1-cffb1c3e2ef6,
  abstract     = {<p>Background and aims We aimed to identify clusters of metabolic syndrome (MetS) components, risky for extremely high intima-media thickness. Methods We studied 41,513 volunteers (men and women) from eleven cohorts worldwide, participating in the MARE (Metabolic syndrome and Artery REsearch) Consortium. Results Specific clusters of MetS components - high triglycerides-high blood pressure-abdominal obesity (TBW), low HDL cholesterol-high blood pressure-abdominal obesity (HBW), high glucose-high blood pressure-abdominal obesity (GBW) - were accompanied by a 50–90% significantly greater likelihood of presenting extremely high intima-media thickness (via ultrasound of carotid artery, CCA IMT), after controlling for age, sex, smoking, non-HDL cholesterol, and presence of diabetes mellitus. This likelihood is comparable to the effect of being 7–8 years older or of being a cigarette smoker or of having non-HDL cholesterol 50 mg/dl higher. Conclusions The consistent association of specific clusters of MetS components with extremely thick (older) large artery cross-culturally suggests that identification of those clusters in clinical practice will facilitate a personalized health care and a better – i.e. more healthy and cost-effective - prevention of major cardiovascular (CV) events.</p>},
  author       = {Scuteri, Angelo and Franco, Oscar H. and Völzke, Henry and Shin, Min Ho and Kweon, Sun Seog and Rietzschel, Ernst and Ryliškytė, Ligita and Strazhesko, Irina and Chen, Chen Huan and Lakatta, Edward G. and Nilsson, Peter M.},
  issn         = {0021-9150},
  keyword      = {Arterial ageing,Arteries,Carotid intima-media thickness,Metabolic syndrome},
  language     = {eng},
  month        = {12},
  pages        = {11--16},
  publisher    = {Elsevier},
  series       = {Atherosclerosis},
  title        = {The relationship between the metabolic syndrome and arterial wall thickness : A mosaic still to be interpreted},
  url          = {http://dx.doi.org/10.1016/j.atherosclerosis.2016.10.032},
  volume       = {255},
  year         = {2016},
}