TFEB: Pathogenic role and therapeutic target in Parkinson disease.
Decressac, Mickael LU and Björklund, Anders LU
(2013)
In Autophagy
9(8).
p.1244-1246
- Abstract
- Parkinson disease (PD) is characterized by the progressive loss of nigral dopamine neurons and the presence of accumulations containing the disease-causing protein SNCA/α-synuclein. Here we review our recent findings describing how SNCA impairs the function of the master regulator of the autophagy-lysosomal pathway (ALP), the transcription factor EB (TFEB), and that genetic or pharmacological stimulation of its activity promotes protection of dopamine neurons. These findings suggest that strategies aimed at enhancing autophagy-mediated degradation of SNCA may hold great promise for disease intervention in PD.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3804059
- author
- Decressac, Mickael
LU
and Björklund, Anders
LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Autophagy
- volume
- 9
- issue
- 8
- pages
- 1244 - 1246
- publisher
- Landes Bioscience
- external identifiers
-
- wos:000323314600011
- pmid:23715007
- scopus:84882950362
- pmid:23715007
- ISSN
- 1554-8635
- DOI
- 10.4161/auto.25044
- language
- English
- LU publication?
- yes
- id
- 8b449b2c-ef07-4669-8799-ea2cccf2e839 (old id 3804059)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/23715007?dopt=Abstract
- date added to LUP
- 2016-04-01 10:32:25
- date last changed
- 2022-04-27 23:04:18
@article{8b449b2c-ef07-4669-8799-ea2cccf2e839,
abstract = {{Parkinson disease (PD) is characterized by the progressive loss of nigral dopamine neurons and the presence of accumulations containing the disease-causing protein SNCA/α-synuclein. Here we review our recent findings describing how SNCA impairs the function of the master regulator of the autophagy-lysosomal pathway (ALP), the transcription factor EB (TFEB), and that genetic or pharmacological stimulation of its activity promotes protection of dopamine neurons. These findings suggest that strategies aimed at enhancing autophagy-mediated degradation of SNCA may hold great promise for disease intervention in PD.}},
author = {{Decressac, Mickael and Björklund, Anders}},
issn = {{1554-8635}},
language = {{eng}},
number = {{8}},
pages = {{1244--1246}},
publisher = {{Landes Bioscience}},
series = {{Autophagy}},
title = {{TFEB: Pathogenic role and therapeutic target in Parkinson disease.}},
url = {{http://dx.doi.org/10.4161/auto.25044}},
doi = {{10.4161/auto.25044}},
volume = {{9}},
year = {{2013}},
}