Stable GAD65 autoantibody epitope patterns in type 1 diabetes children five years after onset.
Hampe, CS ; Hammerle, LP ; Bekris, L ; Ortqvist, E ; Persson, B and Lernmark, Åke LU
(2002)
In Journal of Autoimmunity
18(1).
p.49-53
- Abstract
- Autoantibodies to GAD65 (GAD65Ab) are prominent in type 1 diabetes. These autoantibodies may be present both years before and after the clinical diagnosis of type 1 diabetes and are widely used as a marker for the disease. Recently it has been demonstrated that progression to type 1 diabetes is accompanied by GAD65Ab epitope maturation. Here we examine whether autoantibody maturation processes also progress after the clinical diagnosis of type 1 diabetes. Antibody reactivity to GAD65, GAD67 and GAD65/67 fusion proteins was measured by radioimmunoassays in 62 children with type 1 diabetes. Samples were taken at diagnosis and five years later. While the overall GAD65Ab level declined over time, the epitope pattern was remarkably stable with... (More)
- Autoantibodies to GAD65 (GAD65Ab) are prominent in type 1 diabetes. These autoantibodies may be present both years before and after the clinical diagnosis of type 1 diabetes and are widely used as a marker for the disease. Recently it has been demonstrated that progression to type 1 diabetes is accompanied by GAD65Ab epitope maturation. Here we examine whether autoantibody maturation processes also progress after the clinical diagnosis of type 1 diabetes. Antibody reactivity to GAD65, GAD67 and GAD65/67 fusion proteins was measured by radioimmunoassays in 62 children with type 1 diabetes. Samples were taken at diagnosis and five years later. While the overall GAD65Ab level declined over time, the epitope pattern was remarkably stable with no significant changes in binding pattern. Loss of GAD65Ab-positivity was associated with significantly lower GAD65Ab indices at diagnosis compared to patients' sera that remained GAD65Ab-positive. The decrease in GAD65Ab levels did not correlate to r (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1124232
- author
- Hampe, CS
; Hammerle, LP
; Bekris, L
; Ortqvist, E
; Persson, B
and Lernmark, Åke
LU
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Autoimmunity
- volume
- 18
- issue
- 1
- pages
- 49 - 53
- publisher
- Elsevier
- external identifiers
-
- scopus:0037006434
- pmid:11869046
- ISSN
- 0896-8411
- DOI
- 10.1006/jaut.2001.0564
- language
- English
- LU publication?
- no
- id
- 3815743a-2c59-4c71-b7ff-f24af2d08a9e (old id 1124232)
- date added to LUP
- 2016-04-04 10:15:04
- date last changed
- 2022-02-13 19:29:36
@article{3815743a-2c59-4c71-b7ff-f24af2d08a9e,
abstract = {{Autoantibodies to GAD65 (GAD65Ab) are prominent in type 1 diabetes. These autoantibodies may be present both years before and after the clinical diagnosis of type 1 diabetes and are widely used as a marker for the disease. Recently it has been demonstrated that progression to type 1 diabetes is accompanied by GAD65Ab epitope maturation. Here we examine whether autoantibody maturation processes also progress after the clinical diagnosis of type 1 diabetes. Antibody reactivity to GAD65, GAD67 and GAD65/67 fusion proteins was measured by radioimmunoassays in 62 children with type 1 diabetes. Samples were taken at diagnosis and five years later. While the overall GAD65Ab level declined over time, the epitope pattern was remarkably stable with no significant changes in binding pattern. Loss of GAD65Ab-positivity was associated with significantly lower GAD65Ab indices at diagnosis compared to patients' sera that remained GAD65Ab-positive. The decrease in GAD65Ab levels did not correlate to r}},
author = {{Hampe, CS and Hammerle, LP and Bekris, L and Ortqvist, E and Persson, B and Lernmark, Åke}},
issn = {{0896-8411}},
language = {{eng}},
number = {{1}},
pages = {{49--53}},
publisher = {{Elsevier}},
series = {{Journal of Autoimmunity}},
title = {{Stable GAD65 autoantibody epitope patterns in type 1 diabetes children five years after onset.}},
url = {{http://dx.doi.org/10.1006/jaut.2001.0564}},
doi = {{10.1006/jaut.2001.0564}},
volume = {{18}},
year = {{2002}},
}