Molecular basis of cell-biomaterial interaction: Insights gained from transcriptomic and proteomic studies
(2006) In Biomaterials 27(35). p.5871-5882- Abstract
- With the growing interest in clinical interventions that involve medical devices, the role for new biomaterials in modern medicine is currently expanding at a phenomenal rate. Failure of most implant materials stems from an inability to predict and control biological phenomena, such as protein adsorption and cell interaction, resulting in an inappropriate host response to the materials. Contemporary advances in biological investigation are starting to shift focus in the biomaterials field, in particular with the advent of high-throughput methodologies for gene and protein expression profiling. Here, we examine the role that emerging transcriptomic and proteomic technologies could play in relation to biomaterial development and usage.... (More)
- With the growing interest in clinical interventions that involve medical devices, the role for new biomaterials in modern medicine is currently expanding at a phenomenal rate. Failure of most implant materials stems from an inability to predict and control biological phenomena, such as protein adsorption and cell interaction, resulting in an inappropriate host response to the materials. Contemporary advances in biological investigation are starting to shift focus in the biomaterials field, in particular with the advent of high-throughput methodologies for gene and protein expression profiling. Here, we examine the role that emerging transcriptomic and proteomic technologies could play in relation to biomaterial development and usage. Moreover, a number of studies are highlighted which have utilized such approaches in order to try to create a deeper understanding of cell-biomaterial interactions and, hence, improve our ability to predict and control the biocompatibility of new materials. (c) 2006 Elsevier Ltd. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/384216
- author
- Gallagher, William M. ; Lynch, Iseult LU ; Allen, Lorcan T. ; Miller, Ian ; Penney, Stephen C. ; O'Connor, Darran P. ; Pennington, Stephen ; Keenan, Alan K. and Dawson, Kenneth A.
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- mass, proteomics, DNA microarrays, biocompatibility, transcriptomics, cell interaction, spectrometry
- in
- Biomaterials
- volume
- 27
- issue
- 35
- pages
- 5871 - 5882
- publisher
- Elsevier
- external identifiers
-
- wos:000241633500001
- scopus:33748305553
- ISSN
- 1878-5905
- DOI
- 10.1016/j.biomaterials.2006.07.040
- language
- English
- LU publication?
- yes
- id
- c5e65cbc-9804-4b89-9597-7d9046b26418 (old id 384216)
- date added to LUP
- 2016-04-01 11:46:34
- date last changed
- 2022-02-18 05:08:28
@article{c5e65cbc-9804-4b89-9597-7d9046b26418,
abstract = {{With the growing interest in clinical interventions that involve medical devices, the role for new biomaterials in modern medicine is currently expanding at a phenomenal rate. Failure of most implant materials stems from an inability to predict and control biological phenomena, such as protein adsorption and cell interaction, resulting in an inappropriate host response to the materials. Contemporary advances in biological investigation are starting to shift focus in the biomaterials field, in particular with the advent of high-throughput methodologies for gene and protein expression profiling. Here, we examine the role that emerging transcriptomic and proteomic technologies could play in relation to biomaterial development and usage. Moreover, a number of studies are highlighted which have utilized such approaches in order to try to create a deeper understanding of cell-biomaterial interactions and, hence, improve our ability to predict and control the biocompatibility of new materials. (c) 2006 Elsevier Ltd. All rights reserved.}},
author = {{Gallagher, William M. and Lynch, Iseult and Allen, Lorcan T. and Miller, Ian and Penney, Stephen C. and O'Connor, Darran P. and Pennington, Stephen and Keenan, Alan K. and Dawson, Kenneth A.}},
issn = {{1878-5905}},
keywords = {{mass; proteomics; DNA microarrays; biocompatibility; transcriptomics; cell interaction; spectrometry}},
language = {{eng}},
number = {{35}},
pages = {{5871--5882}},
publisher = {{Elsevier}},
series = {{Biomaterials}},
title = {{Molecular basis of cell-biomaterial interaction: Insights gained from transcriptomic and proteomic studies}},
url = {{http://dx.doi.org/10.1016/j.biomaterials.2006.07.040}},
doi = {{10.1016/j.biomaterials.2006.07.040}},
volume = {{27}},
year = {{2006}},
}