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Estrogen receptor genes variations and breast cancer risk in Iran

Abbasi, Sakineh; Nouri, Mehrnaz LU and Azimi, Cyrus (2012) In International Journal of Clinical and Experimental Medicine 5(4). p.332-341
Abstract
Evidence suggests that alterations in estrogen signaling pathways, including estrogen receptor alpha (ER-alpha) and estrogen receptor beta (ER-beta) occur during breast cancer development. ER-alpha and ER-beta genes polymorphisms have been found to be associated with breast cancer and clinical features of the disease in the western countries. In the current study, we evaluated the hypothesis that certain sequence variants of the ER-alpha and ER-beta genes are associated with an additively increased risk for breast cancer in Iranian women breast cancer patients. The genes were scanned in 150 Iranian patients with newly diagnosed invasive breast tumors and in healthy control individuals by PCR single-strand conformation polymorphism (SSCP)... (More)
Evidence suggests that alterations in estrogen signaling pathways, including estrogen receptor alpha (ER-alpha) and estrogen receptor beta (ER-beta) occur during breast cancer development. ER-alpha and ER-beta genes polymorphisms have been found to be associated with breast cancer and clinical features of the disease in the western countries. In the current study, we evaluated the hypothesis that certain sequence variants of the ER-alpha and ER-beta genes are associated with an additively increased risk for breast cancer in Iranian women breast cancer patients. The genes were scanned in 150 Iranian patients with newly diagnosed invasive breast tumors and in healthy control individuals by PCR single-strand conformation polymorphism (SSCP) method. Three single nucleotide polymorphisms (SNPs) in codon10 (TCT -> TCC), codon 352 (CCG -> CCC) and codon 594 (ACG -> ACA) in ER-alpha gene and one SNP codon 392 (CTC -> CTG) in ER-beta were revealed have additive effects in developing breast cancer and LN metastases. Also, SNP in codon 392 of estrogen receptor-beta gene is more effective (threefold) than those SNPs in codons 10, 325, 594 of estrogen receptor-alpha gene in developing LN metastases in breast cancer patients. SNPs in estrogen receptor alpha and beta have additive effects in increasing risk for developing breast cancer with LN metastases among Iranian women breast cancer patients. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Breast cancer, estrogen receptor, LN metastases, polymorphism
in
International Journal of Clinical and Experimental Medicine
volume
5
issue
4
pages
332 - 341
publisher
e-Century Publishing Corporation
external identifiers
  • wos:000318527000009
  • scopus:84866025508
ISSN
1940-5901
language
English
LU publication?
yes
id
e91549ab-dfc0-4bee-8ed7-8ef359db4f96 (old id 3843112)
alternative location
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443893/
date added to LUP
2013-06-24 10:54:14
date last changed
2017-06-18 04:12:08
@article{e91549ab-dfc0-4bee-8ed7-8ef359db4f96,
  abstract     = {Evidence suggests that alterations in estrogen signaling pathways, including estrogen receptor alpha (ER-alpha) and estrogen receptor beta (ER-beta) occur during breast cancer development. ER-alpha and ER-beta genes polymorphisms have been found to be associated with breast cancer and clinical features of the disease in the western countries. In the current study, we evaluated the hypothesis that certain sequence variants of the ER-alpha and ER-beta genes are associated with an additively increased risk for breast cancer in Iranian women breast cancer patients. The genes were scanned in 150 Iranian patients with newly diagnosed invasive breast tumors and in healthy control individuals by PCR single-strand conformation polymorphism (SSCP) method. Three single nucleotide polymorphisms (SNPs) in codon10 (TCT -> TCC), codon 352 (CCG -> CCC) and codon 594 (ACG -> ACA) in ER-alpha gene and one SNP codon 392 (CTC -> CTG) in ER-beta were revealed have additive effects in developing breast cancer and LN metastases. Also, SNP in codon 392 of estrogen receptor-beta gene is more effective (threefold) than those SNPs in codons 10, 325, 594 of estrogen receptor-alpha gene in developing LN metastases in breast cancer patients. SNPs in estrogen receptor alpha and beta have additive effects in increasing risk for developing breast cancer with LN metastases among Iranian women breast cancer patients.},
  author       = {Abbasi, Sakineh and Nouri, Mehrnaz and Azimi, Cyrus},
  issn         = {1940-5901},
  keyword      = {Breast cancer,estrogen receptor,LN metastases,polymorphism},
  language     = {eng},
  number       = {4},
  pages        = {332--341},
  publisher    = {e-Century Publishing Corporation},
  series       = {International Journal of Clinical and Experimental Medicine},
  title        = {Estrogen receptor genes variations and breast cancer risk in Iran},
  volume       = {5},
  year         = {2012},
}