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Distinct gene expression profiling in chronic lymphocytic leukemia with 11q23 deletion

Aalto, Y; El-Rifai, W; Vilpo, L; Ollila, J; Nagy, B; Vihinen, Mauno LU ; Vilpo, J and Knuutila, S (2001) In Leukemia 15(11). p.1721-1728
Abstract
Chronic lymphocytic leukemia (CLL) is a heterogeneous disease with regard to its clinical course. The limitations of the methods currently available for prognostic assessment in CLL do not allow accurate prediction of the risk of disease progression in Individual patients. The recently developed cDNA array technique provides a unique opportunity to study gene expression in various malignancies. To Identify new molecular markers for prognostication of CLL patients, we analyzed cDNA arrays by using hierarchical clustering and standard statistic t-test on 34 CLL patients. We found significant expression differences in 78 genes compared to the reference tonsillar B lymphocytes. A cluster of genes, LCP1, PARP, BLR1, DEK, NPM, MCL1, SLP76, STAM,... (More)
Chronic lymphocytic leukemia (CLL) is a heterogeneous disease with regard to its clinical course. The limitations of the methods currently available for prognostic assessment in CLL do not allow accurate prediction of the risk of disease progression in Individual patients. The recently developed cDNA array technique provides a unique opportunity to study gene expression in various malignancies. To Identify new molecular markers for prognostication of CLL patients, we analyzed cDNA arrays by using hierarchical clustering and standard statistic t-test on 34 CLL patients. We found significant expression differences in 78 genes compared to the reference tonsillar B lymphocytes. A cluster of genes, LCP1, PARP, BLR1, DEK, NPM, MCL1, SLP76, STAM, HIVEP1, EVI2B, CD25, HTLF, HIVEP2, BCL2, MNDA, PBX3, EBI2, TCF1, CGRP, CD14, IL8, GZMK, GPR17 and CD79B, was associated (P < 0.05) with the unfavorable 11q deletion and also with the unfavorable Binet stages B and C. We present here gene expression profiling that is associated with CLL patients with the 11q23 deletion. Many of the genes in the cluster have not previously been shown to be related to the initiation or progression of CLL. These novel findings provide fundamental information for further attempts to understand the interaction of the clustered genes In the leukomogenesis of CLL in order to better design treatments aimed at specific molecular target(s). (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
chronic lymphocytic leukemia, Binet clinical staging, 11q23 deletion, cDNA array, molecular marker
in
Leukemia
volume
15
issue
11
pages
1721 - 1728
publisher
Nature Publishing Group
external identifiers
  • wos:000171918100009
  • scopus:0035158101
ISSN
1476-5551
language
English
LU publication?
no
id
43004d91-ae24-4f27-8055-ecf975515fdd (old id 3851504)
date added to LUP
2013-06-28 15:22:57
date last changed
2018-10-03 10:09:01
@article{43004d91-ae24-4f27-8055-ecf975515fdd,
  abstract     = {Chronic lymphocytic leukemia (CLL) is a heterogeneous disease with regard to its clinical course. The limitations of the methods currently available for prognostic assessment in CLL do not allow accurate prediction of the risk of disease progression in Individual patients. The recently developed cDNA array technique provides a unique opportunity to study gene expression in various malignancies. To Identify new molecular markers for prognostication of CLL patients, we analyzed cDNA arrays by using hierarchical clustering and standard statistic t-test on 34 CLL patients. We found significant expression differences in 78 genes compared to the reference tonsillar B lymphocytes. A cluster of genes, LCP1, PARP, BLR1, DEK, NPM, MCL1, SLP76, STAM, HIVEP1, EVI2B, CD25, HTLF, HIVEP2, BCL2, MNDA, PBX3, EBI2, TCF1, CGRP, CD14, IL8, GZMK, GPR17 and CD79B, was associated (P &lt; 0.05) with the unfavorable 11q deletion and also with the unfavorable Binet stages B and C. We present here gene expression profiling that is associated with CLL patients with the 11q23 deletion. Many of the genes in the cluster have not previously been shown to be related to the initiation or progression of CLL. These novel findings provide fundamental information for further attempts to understand the interaction of the clustered genes In the leukomogenesis of CLL in order to better design treatments aimed at specific molecular target(s).},
  author       = {Aalto, Y and El-Rifai, W and Vilpo, L and Ollila, J and Nagy, B and Vihinen, Mauno and Vilpo, J and Knuutila, S},
  issn         = {1476-5551},
  keyword      = {chronic lymphocytic leukemia,Binet clinical staging,11q23 deletion,cDNA array,molecular marker},
  language     = {eng},
  number       = {11},
  pages        = {1721--1728},
  publisher    = {Nature Publishing Group},
  series       = {Leukemia},
  title        = {Distinct gene expression profiling in chronic lymphocytic leukemia with 11q23 deletion},
  volume       = {15},
  year         = {2001},
}