Advanced

The Tec family of cytoplasmic tyrosine kinases: mammalian Btk, Bmx, Itk, Tec, Txk and homologs in other species

Smith, CIE; Islam, TC; Mattsson, PT; Mohamed, AJ; Nore, BF and Vihinen, Mauno LU (2001) In BioEssays 23(5). p.436-446
Abstract
Cytoplasmic protein-tyrosine kinases (PTKs) are enzymes involved in transducing a vast number of signals in metazoans, The importance of the Tec family of kinases was immediately recognized when, in 1993, mutations in the gene encoding Bruton's tyrosine kinase (Btk) were reported to cause the human disease X-linked agammaglobulinemia (XLA).((1,2)) Since then, additional kinases belonging to this family have been isolated, and the availability of full genome sequences allows identification of all members in selected species enabling phylogenetic considerations. Tec kinases are endowed with Pleckstrin homology (PH) and Tec homology (TH) domains and are involved in diverse biological processes related to the control of survival and... (More)
Cytoplasmic protein-tyrosine kinases (PTKs) are enzymes involved in transducing a vast number of signals in metazoans, The importance of the Tec family of kinases was immediately recognized when, in 1993, mutations in the gene encoding Bruton's tyrosine kinase (Btk) were reported to cause the human disease X-linked agammaglobulinemia (XLA).((1,2)) Since then, additional kinases belonging to this family have been isolated, and the availability of full genome sequences allows identification of all members in selected species enabling phylogenetic considerations. Tec kinases are endowed with Pleckstrin homology (PH) and Tec homology (TH) domains and are involved in diverse biological processes related to the control of survival and differentiation fate, Membrane translocation resulting in the activation of Tec kinases with subsequent Ca2+ release seems to be a general feature, However, nuclear translocation may also be of importance, the purpose of this essay is to characterize members of the Tec family and discuss their involvement in signaling. The three-dimensional structure, expression pattern and evolutionary aspects will also be considered. (C) 2001 John Wiley & Sons, Inc. (Less)
Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
subject
in
BioEssays
volume
23
issue
5
pages
436 - 446
publisher
John Wiley & Sons
external identifiers
  • wos:000168435600009
  • scopus:0001584969
ISSN
0265-9247
DOI
10.1002/bies.1062
language
English
LU publication?
no
id
5a43efe6-42f6-4c99-8e88-71639cd1582c (old id 3851659)
date added to LUP
2013-06-28 15:25:11
date last changed
2018-07-15 03:27:05
@article{5a43efe6-42f6-4c99-8e88-71639cd1582c,
  abstract     = {Cytoplasmic protein-tyrosine kinases (PTKs) are enzymes involved in transducing a vast number of signals in metazoans, The importance of the Tec family of kinases was immediately recognized when, in 1993, mutations in the gene encoding Bruton's tyrosine kinase (Btk) were reported to cause the human disease X-linked agammaglobulinemia (XLA).((1,2)) Since then, additional kinases belonging to this family have been isolated, and the availability of full genome sequences allows identification of all members in selected species enabling phylogenetic considerations. Tec kinases are endowed with Pleckstrin homology (PH) and Tec homology (TH) domains and are involved in diverse biological processes related to the control of survival and differentiation fate, Membrane translocation resulting in the activation of Tec kinases with subsequent Ca2+ release seems to be a general feature, However, nuclear translocation may also be of importance, the purpose of this essay is to characterize members of the Tec family and discuss their involvement in signaling. The three-dimensional structure, expression pattern and evolutionary aspects will also be considered. (C) 2001 John Wiley & Sons, Inc.},
  author       = {Smith, CIE and Islam, TC and Mattsson, PT and Mohamed, AJ and Nore, BF and Vihinen, Mauno},
  issn         = {0265-9247},
  language     = {eng},
  number       = {5},
  pages        = {436--446},
  publisher    = {John Wiley & Sons},
  series       = {BioEssays},
  title        = {The Tec family of cytoplasmic tyrosine kinases: mammalian Btk, Bmx, Itk, Tec, Txk and homologs in other species},
  url          = {http://dx.doi.org/10.1002/bies.1062},
  volume       = {23},
  year         = {2001},
}