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Identification of novel transcription factor-like gene from human intestinal cells

Lindfors, K; Halttunen, T; Huotari, P; Nupponen, N; Vihinen, Mauno LU ; Visakorpi, T; Maki, M and Kainulainen, H (2000) In Biochemical and Biophysical Research Communications 276(2). p.660-666
Abstract
Intestinal crypt epithelial T84 cells form luminal structures and differentiate to intestinal enterocyte-like cells in response to IMR-90 fibroblast-secreted transforming growth factor-beta when grown within three-dimensional collagen gel. In search of TGF-beta regulated genes involved in this differentiation process, we isolated a TGF-beta downregulated cDNA, human homologue of rat apoptosis antagonising transcription factor that codes for a 560-amino-acid protein. Human AATF-mRNA was expressed at high levels in human brain, heart, thymus, kidney, and placenta while in skeletal muscle and colon the expression was lower. The gene was mapped to chromosome 17q11.2-q12. (C) 2000 Academic Press.
Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
TGF-beta, differentiation, transcription factor, AATF
in
Biochemical and Biophysical Research Communications
volume
276
issue
2
pages
660 - 666
publisher
Elsevier
external identifiers
  • wos:000089558600043
  • scopus:0034710824
ISSN
1090-2104
DOI
10.1006/bbrc.2000.3480
language
English
LU publication?
no
id
a251c746-e9fc-4901-b191-971453e29818 (old id 3851981)
date added to LUP
2013-06-28 15:29:07
date last changed
2017-04-09 04:13:48
@article{a251c746-e9fc-4901-b191-971453e29818,
  abstract     = {Intestinal crypt epithelial T84 cells form luminal structures and differentiate to intestinal enterocyte-like cells in response to IMR-90 fibroblast-secreted transforming growth factor-beta when grown within three-dimensional collagen gel. In search of TGF-beta regulated genes involved in this differentiation process, we isolated a TGF-beta downregulated cDNA, human homologue of rat apoptosis antagonising transcription factor that codes for a 560-amino-acid protein. Human AATF-mRNA was expressed at high levels in human brain, heart, thymus, kidney, and placenta while in skeletal muscle and colon the expression was lower. The gene was mapped to chromosome 17q11.2-q12. (C) 2000 Academic Press.},
  author       = {Lindfors, K and Halttunen, T and Huotari, P and Nupponen, N and Vihinen, Mauno and Visakorpi, T and Maki, M and Kainulainen, H},
  issn         = {1090-2104},
  keyword      = {TGF-beta,differentiation,transcription factor,AATF},
  language     = {eng},
  number       = {2},
  pages        = {660--666},
  publisher    = {Elsevier},
  series       = {Biochemical and Biophysical Research Communications},
  title        = {Identification of novel transcription factor-like gene from human intestinal cells},
  url          = {http://dx.doi.org/10.1006/bbrc.2000.3480},
  volume       = {276},
  year         = {2000},
}