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KinMutBase, a database of human disease-causing protein kinase mutations

Stenberg, KAE; Riikonen, PT and Vihinen, Mauno LU (2000) In Nucleic Acids Research 28(1). p.369-371
Abstract
KinMutBase (http://www.uta.fi/imt/bioinfo/KinMutBase/) is a registry of mutations in human protein kinases related to-disorders. Kinases are essential cellular signaling molecules, in which mutations can lead to diseases, including immunodeficiencies, cancers and endocrine disorders, The first release of KinMutBase contained information for protein tyrosine kinases. The current release includes also serine/threonine protein kinases, as well as an update of the tyrosine kinases, There are 251 entries altogether, representing 337 families and 621 patients. Mutations appear both in conserved hallmark residues of the kinases as well as in non-homologous sites. The KinMutBase WWW pages provide plenty of information, namely mutation statistics... (More)
KinMutBase (http://www.uta.fi/imt/bioinfo/KinMutBase/) is a registry of mutations in human protein kinases related to-disorders. Kinases are essential cellular signaling molecules, in which mutations can lead to diseases, including immunodeficiencies, cancers and endocrine disorders, The first release of KinMutBase contained information for protein tyrosine kinases. The current release includes also serine/threonine protein kinases, as well as an update of the tyrosine kinases, There are 251 entries altogether, representing 337 families and 621 patients. Mutations appear both in conserved hallmark residues of the kinases as well as in non-homologous sites. The KinMutBase WWW pages provide plenty of information, namely mutation statistics land display, clickable sequences with mutations and changes to restriction enzyme patterns. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
in
Nucleic Acids Research
volume
28
issue
1
pages
369 - 371
publisher
Oxford University Press
external identifiers
  • wos:000084896300110
  • scopus:0033970710
ISSN
1362-4962
DOI
10.1093/nar/28.1.369
language
English
LU publication?
no
id
baf414bb-30a2-4dbd-a71c-aa37584c7435 (old id 3852294)
date added to LUP
2013-06-28 13:19:52
date last changed
2017-08-27 04:24:17
@article{baf414bb-30a2-4dbd-a71c-aa37584c7435,
  abstract     = {KinMutBase (http://www.uta.fi/imt/bioinfo/KinMutBase/) is a registry of mutations in human protein kinases related to-disorders. Kinases are essential cellular signaling molecules, in which mutations can lead to diseases, including immunodeficiencies, cancers and endocrine disorders, The first release of KinMutBase contained information for protein tyrosine kinases. The current release includes also serine/threonine protein kinases, as well as an update of the tyrosine kinases, There are 251 entries altogether, representing 337 families and 621 patients. Mutations appear both in conserved hallmark residues of the kinases as well as in non-homologous sites. The KinMutBase WWW pages provide plenty of information, namely mutation statistics land display, clickable sequences with mutations and changes to restriction enzyme patterns.},
  author       = {Stenberg, KAE and Riikonen, PT and Vihinen, Mauno},
  issn         = {1362-4962},
  language     = {eng},
  number       = {1},
  pages        = {369--371},
  publisher    = {Oxford University Press},
  series       = {Nucleic Acids Research},
  title        = {KinMutBase, a database of human disease-causing protein kinase mutations},
  url          = {http://dx.doi.org/10.1093/nar/28.1.369},
  volume       = {28},
  year         = {2000},
}