Advanced

KinMutBase, a database of human disease-causing protein kinase mutations

Stenberg, KAE; Riikonen, PT and Vihinen, Mauno LU (1999) In Nucleic Acids Research 27(1). p.362-364
Abstract
KinMutBase (http://www.uta.fi/laitokset/imt/KinMutBase. html) is a registry of mutations in human protein kinases related to disorders. Kinases are essential cellular signalling molecules, in which mutations can lead into diseases including, e.g., immunodeficiencies, cancers and endocrine disorders. The first release of KinMutBase contains information for nine protein tyrosine kinases. There are altogether 170 entries representing 273 families and 403 patients. Mutations appear both in conserved hallmark residues of the kinases as well as in non-homologous sites. The KinMutBase WWW pages provide plenty of information, namely mutation statistics and display, clickable sequences with mutations, restriction enzyme patterns and online... (More)
KinMutBase (http://www.uta.fi/laitokset/imt/KinMutBase. html) is a registry of mutations in human protein kinases related to disorders. Kinases are essential cellular signalling molecules, in which mutations can lead into diseases including, e.g., immunodeficiencies, cancers and endocrine disorders. The first release of KinMutBase contains information for nine protein tyrosine kinases. There are altogether 170 entries representing 273 families and 403 patients. Mutations appear both in conserved hallmark residues of the kinases as well as in non-homologous sites. The KinMutBase WWW pages provide plenty of information, namely mutation statistics and display, clickable sequences with mutations, restriction enzyme patterns and online submission. (Less)
Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
subject
in
Nucleic Acids Research
volume
27
issue
1
pages
362 - 364
publisher
Oxford University Press
external identifiers
  • wos:000077983000100
  • scopus:0032895474
ISSN
1362-4962
DOI
10.1093/nar/27.1.362
language
English
LU publication?
no
id
28b6cfd3-e0c2-4280-87c6-5339789cd376 (old id 3852360)
date added to LUP
2013-06-28 13:25:09
date last changed
2017-01-01 04:20:37
@article{28b6cfd3-e0c2-4280-87c6-5339789cd376,
  abstract     = {KinMutBase (http://www.uta.fi/laitokset/imt/KinMutBase. html) is a registry of mutations in human protein kinases related to disorders. Kinases are essential cellular signalling molecules, in which mutations can lead into diseases including, e.g., immunodeficiencies, cancers and endocrine disorders. The first release of KinMutBase contains information for nine protein tyrosine kinases. There are altogether 170 entries representing 273 families and 403 patients. Mutations appear both in conserved hallmark residues of the kinases as well as in non-homologous sites. The KinMutBase WWW pages provide plenty of information, namely mutation statistics and display, clickable sequences with mutations, restriction enzyme patterns and online submission.},
  author       = {Stenberg, KAE and Riikonen, PT and Vihinen, Mauno},
  issn         = {1362-4962},
  language     = {eng},
  number       = {1},
  pages        = {362--364},
  publisher    = {Oxford University Press},
  series       = {Nucleic Acids Research},
  title        = {KinMutBase, a database of human disease-causing protein kinase mutations},
  url          = {http://dx.doi.org/10.1093/nar/27.1.362},
  volume       = {27},
  year         = {1999},
}