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Stimulation of B and T cells activates expression of transcription and differentiation factors

Ollila, J and Vihinen, Mauno LU (1998) In Biochemical and Biophysical Research Communications 249(2). p.475-480
Abstract
During B and T cell differentiation and proliferation many genes are induced or repressed while certain genes are constitutively expressed. To investigate processes related to B and T cell activation, the gene expression of stimulated and nonstimutated Ramos and Jurkat cells was studied using cDNA microarray technology. Simultaneous analysis of close to 600 genes indicated highest increase in the expression of certain transcription, differentiation and proliferation factors. Many of these genes have not previously been shown to funcion in the stimulated lymphocytes. Also genes encoding proteins involved in DNA replication, binding, transcription and translation were induced. Large part of the activated genes were under very stringent... (More)
During B and T cell differentiation and proliferation many genes are induced or repressed while certain genes are constitutively expressed. To investigate processes related to B and T cell activation, the gene expression of stimulated and nonstimutated Ramos and Jurkat cells was studied using cDNA microarray technology. Simultaneous analysis of close to 600 genes indicated highest increase in the expression of certain transcription, differentiation and proliferation factors. Many of these genes have not previously been shown to funcion in the stimulated lymphocytes. Also genes encoding proteins involved in DNA replication, binding, transcription and translation were induced. Large part of the activated genes were under very stringent regulation being expressed only after stimulation. The mechanism and function of the expressed genes during lymphocyte differentiation and in disorders is discussed. (C) 1998 Academic Press. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
in
Biochemical and Biophysical Research Communications
volume
249
issue
2
pages
475 - 480
publisher
Elsevier
external identifiers
  • wos:000075515900032
  • scopus:0032547234
ISSN
1090-2104
DOI
10.1006/bbrc.1998.9176
language
English
LU publication?
no
id
bf94357e-4948-407f-8623-1647e73a5f66 (old id 3852418)
date added to LUP
2013-06-28 14:11:04
date last changed
2017-08-20 04:31:32
@article{bf94357e-4948-407f-8623-1647e73a5f66,
  abstract     = {During B and T cell differentiation and proliferation many genes are induced or repressed while certain genes are constitutively expressed. To investigate processes related to B and T cell activation, the gene expression of stimulated and nonstimutated Ramos and Jurkat cells was studied using cDNA microarray technology. Simultaneous analysis of close to 600 genes indicated highest increase in the expression of certain transcription, differentiation and proliferation factors. Many of these genes have not previously been shown to funcion in the stimulated lymphocytes. Also genes encoding proteins involved in DNA replication, binding, transcription and translation were induced. Large part of the activated genes were under very stringent regulation being expressed only after stimulation. The mechanism and function of the expressed genes during lymphocyte differentiation and in disorders is discussed. (C) 1998 Academic Press.},
  author       = {Ollila, J and Vihinen, Mauno},
  issn         = {1090-2104},
  language     = {eng},
  number       = {2},
  pages        = {475--480},
  publisher    = {Elsevier},
  series       = {Biochemical and Biophysical Research Communications},
  title        = {Stimulation of B and T cells activates expression of transcription and differentiation factors},
  url          = {http://dx.doi.org/10.1006/bbrc.1998.9176},
  volume       = {249},
  year         = {1998},
}