Structural aspects of signal transduction in B-cells
Vihinen, Mauno LU
and Smith, CIE
(1996)
In Critical Reviews in Immunology
16(3).
p.251-275
- Abstract
- Signal transduction in hematopoietic cells is a highly specific process. The stimulation of B cell receptor following antigen binding triggers, as a first step, phosphorylation of the cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs). Src family tyrosine kinases Blk, Fyn, Lck, and Lyn as well as spleen kinase, Syk, are activated to transmit the signal further. In this review the signaling events are discussed in structural terms. The factors related to B cell maturation and their targeted mutations are reviewed. During the last 2 years plenty of structural information concerning signaling molecules in B cells has been obtained by using Xray crystallography, NMR spectroscopy, molecular modeling, and mutational analysis.... (More)
- Signal transduction in hematopoietic cells is a highly specific process. The stimulation of B cell receptor following antigen binding triggers, as a first step, phosphorylation of the cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs). Src family tyrosine kinases Blk, Fyn, Lck, and Lyn as well as spleen kinase, Syk, are activated to transmit the signal further. In this review the signaling events are discussed in structural terms. The factors related to B cell maturation and their targeted mutations are reviewed. During the last 2 years plenty of structural information concerning signaling molecules in B cells has been obtained by using Xray crystallography, NMR spectroscopy, molecular modeling, and mutational analysis. The molecules discussed include Src family kinases, Syk, Grb2 adaptor protein, and Tec family kinases Bmx and Btk. The structure, function, and interactions of these signaling compounds are described in atomic detail. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3853108
- author
- Vihinen, Mauno
LU
and Smith, CIE
- publishing date
- 1996
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- signal transduction, Btk, XLA, protein kinases, SH2, SH3, PH, TH
- in
- Critical Reviews in Immunology
- volume
- 16
- issue
- 3
- pages
- 251 - 275
- publisher
- Begell House
- external identifiers
-
- wos:A1996VQ34600002
- scopus:10344244510
- ISSN
- 1040-8401
- language
- English
- LU publication?
- no
- id
- c21f97ad-f339-4bb2-9611-e39104f630c7 (old id 3853108)
- date added to LUP
- 2016-04-01 11:38:42
- date last changed
- 2022-01-26 08:05:34
@article{c21f97ad-f339-4bb2-9611-e39104f630c7,
abstract = {{Signal transduction in hematopoietic cells is a highly specific process. The stimulation of B cell receptor following antigen binding triggers, as a first step, phosphorylation of the cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs). Src family tyrosine kinases Blk, Fyn, Lck, and Lyn as well as spleen kinase, Syk, are activated to transmit the signal further. In this review the signaling events are discussed in structural terms. The factors related to B cell maturation and their targeted mutations are reviewed. During the last 2 years plenty of structural information concerning signaling molecules in B cells has been obtained by using Xray crystallography, NMR spectroscopy, molecular modeling, and mutational analysis. The molecules discussed include Src family kinases, Syk, Grb2 adaptor protein, and Tec family kinases Bmx and Btk. The structure, function, and interactions of these signaling compounds are described in atomic detail.}},
author = {{Vihinen, Mauno and Smith, CIE}},
issn = {{1040-8401}},
keywords = {{signal transduction; Btk; XLA; protein kinases; SH2; SH3; PH; TH}},
language = {{eng}},
number = {{3}},
pages = {{251--275}},
publisher = {{Begell House}},
series = {{Critical Reviews in Immunology}},
title = {{Structural aspects of signal transduction in B-cells}},
volume = {{16}},
year = {{1996}},
}