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Structural aspects of signal transduction in B-cells

Vihinen, Mauno LU and Smith, CIE (1996) In Critical Reviews in Immunology 16(3). p.251-275
Abstract
Signal transduction in hematopoietic cells is a highly specific process. The stimulation of B cell receptor following antigen binding triggers, as a first step, phosphorylation of the cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs). Src family tyrosine kinases Blk, Fyn, Lck, and Lyn as well as spleen kinase, Syk, are activated to transmit the signal further. In this review the signaling events are discussed in structural terms. The factors related to B cell maturation and their targeted mutations are reviewed. During the last 2 years plenty of structural information concerning signaling molecules in B cells has been obtained by using Xray crystallography, NMR spectroscopy, molecular modeling, and mutational analysis.... (More)
Signal transduction in hematopoietic cells is a highly specific process. The stimulation of B cell receptor following antigen binding triggers, as a first step, phosphorylation of the cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs). Src family tyrosine kinases Blk, Fyn, Lck, and Lyn as well as spleen kinase, Syk, are activated to transmit the signal further. In this review the signaling events are discussed in structural terms. The factors related to B cell maturation and their targeted mutations are reviewed. During the last 2 years plenty of structural information concerning signaling molecules in B cells has been obtained by using Xray crystallography, NMR spectroscopy, molecular modeling, and mutational analysis. The molecules discussed include Src family kinases, Syk, Grb2 adaptor protein, and Tec family kinases Bmx and Btk. The structure, function, and interactions of these signaling compounds are described in atomic detail. (Less)
Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
signal transduction, Btk, XLA, protein kinases, SH2, SH3, PH, TH
in
Critical Reviews in Immunology
volume
16
issue
3
pages
251 - 275
publisher
Begell House
external identifiers
  • wos:A1996VQ34600002
  • scopus:10344244510
ISSN
1040-8401
language
English
LU publication?
no
id
c21f97ad-f339-4bb2-9611-e39104f630c7 (old id 3853108)
date added to LUP
2013-06-28 14:36:05
date last changed
2017-01-01 04:24:06
@article{c21f97ad-f339-4bb2-9611-e39104f630c7,
  abstract     = {Signal transduction in hematopoietic cells is a highly specific process. The stimulation of B cell receptor following antigen binding triggers, as a first step, phosphorylation of the cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs). Src family tyrosine kinases Blk, Fyn, Lck, and Lyn as well as spleen kinase, Syk, are activated to transmit the signal further. In this review the signaling events are discussed in structural terms. The factors related to B cell maturation and their targeted mutations are reviewed. During the last 2 years plenty of structural information concerning signaling molecules in B cells has been obtained by using Xray crystallography, NMR spectroscopy, molecular modeling, and mutational analysis. The molecules discussed include Src family kinases, Syk, Grb2 adaptor protein, and Tec family kinases Bmx and Btk. The structure, function, and interactions of these signaling compounds are described in atomic detail.},
  author       = {Vihinen, Mauno and Smith, CIE},
  issn         = {1040-8401},
  keyword      = {signal transduction,Btk,XLA,protein kinases,SH2,SH3,PH,TH},
  language     = {eng},
  number       = {3},
  pages        = {251--275},
  publisher    = {Begell House},
  series       = {Critical Reviews in Immunology},
  title        = {Structural aspects of signal transduction in B-cells},
  volume       = {16},
  year         = {1996},
}