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STRUCTURAL BASIS OF SH2 DOMAIN MUTATIONS IN X-LINKED AGAMMAGLOBULINEMIA

Vihinen, Mauno LU ; NILSSON, L and SMITH, CIE (1994) In Biochemical and Biophysical Research Communications 205(2). p.1270-1277
Abstract
The three-dimensional structure of Bruton's agammaloglobulinemia tyrosine kinase (Btk) SH2 domain was modeled based on v-Src. Btk SH2 is presumably very related to the other SH2 structures consisting of two beta-sheets surrounded by two alpha-helices, with a well conserved hydrophobic core and phoshotyrosyl peptide binding site. The model was used to predict the recognition sequence of the target protein, which probably is YEXI/L. Mutations in the Btk sequence can cause the human disease X-linked agammaglobulinemia and reasons for the disease in Btk SH2 mutations were inferred from the model. (C) 1994 Academic Press, Inc.
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author
publishing date
type
Contribution to journal
publication status
published
subject
in
Biochemical and Biophysical Research Communications
volume
205
issue
2
pages
1270 - 1277
publisher
Elsevier
external identifiers
  • wos:A1994PY70600041
  • scopus:0028641301
ISSN
1090-2104
DOI
10.1006/bbrc.1994.2802
language
English
LU publication?
no
id
f389173a-85b3-4b8c-af15-7d63d53e6829 (old id 3853337)
date added to LUP
2013-06-28 14:39:50
date last changed
2017-07-30 04:39:22
@article{f389173a-85b3-4b8c-af15-7d63d53e6829,
  abstract     = {The three-dimensional structure of Bruton's agammaloglobulinemia tyrosine kinase (Btk) SH2 domain was modeled based on v-Src. Btk SH2 is presumably very related to the other SH2 structures consisting of two beta-sheets surrounded by two alpha-helices, with a well conserved hydrophobic core and phoshotyrosyl peptide binding site. The model was used to predict the recognition sequence of the target protein, which probably is YEXI/L. Mutations in the Btk sequence can cause the human disease X-linked agammaglobulinemia and reasons for the disease in Btk SH2 mutations were inferred from the model. (C) 1994 Academic Press, Inc.},
  author       = {Vihinen, Mauno and NILSSON, L and SMITH, CIE},
  issn         = {1090-2104},
  language     = {eng},
  number       = {2},
  pages        = {1270--1277},
  publisher    = {Elsevier},
  series       = {Biochemical and Biophysical Research Communications},
  title        = {STRUCTURAL BASIS OF SH2 DOMAIN MUTATIONS IN X-LINKED AGAMMAGLOBULINEMIA},
  url          = {http://dx.doi.org/10.1006/bbrc.1994.2802},
  volume       = {205},
  year         = {1994},
}