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TEC HOMOLOGY (TH) ADJACENT TO THE PH DOMAIN

Vihinen, Mauno LU ; NILSSON, L and SMITH, CIE (1994) In FEBS Letters 350(2-3). p.263-265
Abstract
The pleckstrin homology (PH) domain is extended in the Btk kinase family by a region designated the TH (Tee homology) domain, which consists of about 80 residues preceding the SH3 domain. The TH domain contains a conserved 27 amino acid stretch designated the Btk motif and a proline-rich region. Sequence similarity was found to a putative Pas GTPase activating protein and a human interferon-gamma binding protein both in the PH domain and the Btk motif region. SLK1/SSP31 protein kinase and a non-catalytic p85 subunit of PI-3 kinase had similarity only with the proline rich region. The identification of a PH domain extension in some signal transduction proteins in different species suggests that this region is involved in protein-protein... (More)
The pleckstrin homology (PH) domain is extended in the Btk kinase family by a region designated the TH (Tee homology) domain, which consists of about 80 residues preceding the SH3 domain. The TH domain contains a conserved 27 amino acid stretch designated the Btk motif and a proline-rich region. Sequence similarity was found to a putative Pas GTPase activating protein and a human interferon-gamma binding protein both in the PH domain and the Btk motif region. SLK1/SSP31 protein kinase and a non-catalytic p85 subunit of PI-3 kinase had similarity only with the proline rich region. The identification of a PH domain extension in some signal transduction proteins in different species suggests that this region is involved in protein-protein interactions. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
CYTOPLASMIC TYROSINE KINASE, SIGNAL TRANSDUCTION, BTK, BRUTONS AGAMMAGLOBULINEMIA TYROSINE KINASE, XLA, X-LINKED AGAMMAGLOBULINEMIA
in
FEBS Letters
volume
350
issue
2-3
pages
263 - 265
publisher
Wiley-Blackwell
external identifiers
  • wos:A1994PD82000026
  • scopus:0027941128
ISSN
1873-3468
DOI
10.1016/0014-5793(94)00783-7
language
English
LU publication?
no
id
99651cf6-330b-4962-bb7b-7b5e1615740f (old id 3853371)
date added to LUP
2013-06-28 14:49:14
date last changed
2017-08-27 05:12:45
@article{99651cf6-330b-4962-bb7b-7b5e1615740f,
  abstract     = {The pleckstrin homology (PH) domain is extended in the Btk kinase family by a region designated the TH (Tee homology) domain, which consists of about 80 residues preceding the SH3 domain. The TH domain contains a conserved 27 amino acid stretch designated the Btk motif and a proline-rich region. Sequence similarity was found to a putative Pas GTPase activating protein and a human interferon-gamma binding protein both in the PH domain and the Btk motif region. SLK1/SSP31 protein kinase and a non-catalytic p85 subunit of PI-3 kinase had similarity only with the proline rich region. The identification of a PH domain extension in some signal transduction proteins in different species suggests that this region is involved in protein-protein interactions.},
  author       = {Vihinen, Mauno and NILSSON, L and SMITH, CIE},
  issn         = {1873-3468},
  keyword      = {CYTOPLASMIC TYROSINE KINASE,SIGNAL TRANSDUCTION,BTK,BRUTONS AGAMMAGLOBULINEMIA TYROSINE KINASE,XLA,X-LINKED AGAMMAGLOBULINEMIA},
  language     = {eng},
  number       = {2-3},
  pages        = {263--265},
  publisher    = {Wiley-Blackwell},
  series       = {FEBS Letters},
  title        = {TEC HOMOLOGY (TH) ADJACENT TO THE PH DOMAIN},
  url          = {http://dx.doi.org/10.1016/0014-5793(94)00783-7},
  volume       = {350},
  year         = {1994},
}