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Time Trends in the Use of Coronary Procedures, Guideline-Based Therapy, and All-Cause Mortality following the Acute Coronary Syndrome in Patients with Schizophrenia

Attar, Rubina LU orcid ; Jensen, Svend Eggert ; Nielsen, Rene Ernst ; Polcwiartek, Christoffer ; Andell, Pontus LU ; Pedersen, Christian Torp and Kragholm, Kristian (2020) In Cardiology 145(7). p.401-409
Abstract

AIM: Schizophrenia is associated with high cardiovascular mortality predominantly as a result of acute coronary syndrome (ACS). The aim of this study is to analyze time trends of coronary procedures, guideline-based therapy, and all-cause mortality in patients diagnosed with schizophrenia.

METHODS AND RESULTS: This Danish nationwide register-based study analyzed 734 patients with a baseline diagnosis of schizophrenia and an incident diagnosis of ACS in the period between January 1, 1996, and December 31, 2015. The 734 patients with schizophrenia were matched to 2,202 psychiatric healthy controls (PHC). No change over time was seen in the relative difference between the population with schizophrenia and the PHC in the use of... (More)

AIM: Schizophrenia is associated with high cardiovascular mortality predominantly as a result of acute coronary syndrome (ACS). The aim of this study is to analyze time trends of coronary procedures, guideline-based therapy, and all-cause mortality in patients diagnosed with schizophrenia.

METHODS AND RESULTS: This Danish nationwide register-based study analyzed 734 patients with a baseline diagnosis of schizophrenia and an incident diagnosis of ACS in the period between January 1, 1996, and December 31, 2015. The 734 patients with schizophrenia were matched to 2,202 psychiatric healthy controls (PHC). No change over time was seen in the relative difference between the population with schizophrenia and the PHC in the use of coronary angiography, percutaneous coronary intervention, and coronary bypass grafting, nor in 1-year mortality or guideline-based therapy following ACS. Patients with schizophrenia had higher prevalence rates of diabetes, chronic obstructive pulmonary disease, and stroke, and a lower prevalence of hypertension (p < 0.05).

CONCLUSION: The gap in the use of coronary procedures, guideline-based therapy, and all-cause mortality following ACS in patients with schizophrenia compared to those without has remained constant over the past 2 decades.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cardiology
volume
145
issue
7
pages
401 - 409
publisher
Karger
external identifiers
  • pmid:32460291
  • scopus:85088209860
ISSN
1421-9751
DOI
10.1159/000507044
language
English
LU publication?
yes
additional info
© 2020 S. Karger AG, Basel.
id
385cd9dc-5b12-4afe-a3bf-0a2a1fdb78d0
date added to LUP
2020-10-09 11:48:22
date last changed
2024-05-01 17:26:24
@article{385cd9dc-5b12-4afe-a3bf-0a2a1fdb78d0,
  abstract     = {{<p>AIM: Schizophrenia is associated with high cardiovascular mortality predominantly as a result of acute coronary syndrome (ACS). The aim of this study is to analyze time trends of coronary procedures, guideline-based therapy, and all-cause mortality in patients diagnosed with schizophrenia.</p><p>METHODS AND RESULTS: This Danish nationwide register-based study analyzed 734 patients with a baseline diagnosis of schizophrenia and an incident diagnosis of ACS in the period between January 1, 1996, and December 31, 2015. The 734 patients with schizophrenia were matched to 2,202 psychiatric healthy controls (PHC). No change over time was seen in the relative difference between the population with schizophrenia and the PHC in the use of coronary angiography, percutaneous coronary intervention, and coronary bypass grafting, nor in 1-year mortality or guideline-based therapy following ACS. Patients with schizophrenia had higher prevalence rates of diabetes, chronic obstructive pulmonary disease, and stroke, and a lower prevalence of hypertension (p &lt; 0.05).</p><p>CONCLUSION: The gap in the use of coronary procedures, guideline-based therapy, and all-cause mortality following ACS in patients with schizophrenia compared to those without has remained constant over the past 2 decades.</p>}},
  author       = {{Attar, Rubina and Jensen, Svend Eggert and Nielsen, Rene Ernst and Polcwiartek, Christoffer and Andell, Pontus and Pedersen, Christian Torp and Kragholm, Kristian}},
  issn         = {{1421-9751}},
  language     = {{eng}},
  number       = {{7}},
  pages        = {{401--409}},
  publisher    = {{Karger}},
  series       = {{Cardiology}},
  title        = {{Time Trends in the Use of Coronary Procedures, Guideline-Based Therapy, and All-Cause Mortality following the Acute Coronary Syndrome in Patients with Schizophrenia}},
  url          = {{http://dx.doi.org/10.1159/000507044}},
  doi          = {{10.1159/000507044}},
  volume       = {{145}},
  year         = {{2020}},
}