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Sense-Antisense lncRNA Pair Encoded by Locus 6p22.3 Determines Neuroblastoma Susceptibility via the USP36-CHD7-SOX9 Regulatory Axis

Mondal, Tanmoy ; Juvvuna, Prasanna Kumar ; Kirkeby, Agnete LU ; Mitra, Sanhita ; Kosalai, Subazini Thankaswamy ; Traxler, Larissa ; Hertwig, Falk LU ; Wernig-Zorc, Sara ; Miranda, Caroline and Deland, Lily , et al. (2018) In Cancer Cell 33(3). p.7-434
Abstract

Trait-associated loci often map to genomic regions encoding long noncoding RNAs (lncRNAs), but the role of these lncRNAs in disease etiology is largely unexplored. We show that a pair of sense/antisense lncRNA (6p22lncRNAs) encoded by CASC15 and NBAT1 located at the neuroblastoma (NB) risk-associated 6p22.3 locus are tumor suppressors and show reduced expression in high-risk NBs. Loss of functional synergy between 6p22lncRNAs results in an undifferentiated state that is maintained by a gene-regulatory network, including SOX9 located on 17q, a region frequently gained in NB. 6p22lncRNAs regulate SOX9 expression by controlling CHD7 stability via modulating the cellular localization of USP36, encoded by another 17q gene. This regulatory... (More)

Trait-associated loci often map to genomic regions encoding long noncoding RNAs (lncRNAs), but the role of these lncRNAs in disease etiology is largely unexplored. We show that a pair of sense/antisense lncRNA (6p22lncRNAs) encoded by CASC15 and NBAT1 located at the neuroblastoma (NB) risk-associated 6p22.3 locus are tumor suppressors and show reduced expression in high-risk NBs. Loss of functional synergy between 6p22lncRNAs results in an undifferentiated state that is maintained by a gene-regulatory network, including SOX9 located on 17q, a region frequently gained in NB. 6p22lncRNAs regulate SOX9 expression by controlling CHD7 stability via modulating the cellular localization of USP36, encoded by another 17q gene. This regulatory nexus between 6p22.3 and 17q regions may lead to potential NB treatment strategies. Mondal et al. show a sense/antisense lncRNA pair expressed from the neuroblastoma (NB) risk-associated 6p22.3 locus is important for retinoic acid-induced NB differentiation gene-regulatory network by controlling CHD7 stability via modulating the cellular localization of the ubiquitin specific protease USP36.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
CASC15, CHD7, lncRNA, long noncoding RNA, NBAT1, neuroblastoma, neuronal differentiation, SOX9, ubiquitination, USP36
in
Cancer Cell
volume
33
issue
3
pages
7 - 434
publisher
Cell Press
external identifiers
  • scopus:85042857305
  • pmid:29533783
ISSN
1535-6108
DOI
10.1016/j.ccell.2018.01.020
language
English
LU publication?
yes
id
386a4d46-dfda-40ed-bb00-adcd85c135fd
date added to LUP
2018-03-29 11:16:57
date last changed
2024-04-15 04:34:10
@article{386a4d46-dfda-40ed-bb00-adcd85c135fd,
  abstract     = {{<p>Trait-associated loci often map to genomic regions encoding long noncoding RNAs (lncRNAs), but the role of these lncRNAs in disease etiology is largely unexplored. We show that a pair of sense/antisense lncRNA (6p22lncRNAs) encoded by CASC15 and NBAT1 located at the neuroblastoma (NB) risk-associated 6p22.3 locus are tumor suppressors and show reduced expression in high-risk NBs. Loss of functional synergy between 6p22lncRNAs results in an undifferentiated state that is maintained by a gene-regulatory network, including SOX9 located on 17q, a region frequently gained in NB. 6p22lncRNAs regulate SOX9 expression by controlling CHD7 stability via modulating the cellular localization of USP36, encoded by another 17q gene. This regulatory nexus between 6p22.3 and 17q regions may lead to potential NB treatment strategies. Mondal et al. show a sense/antisense lncRNA pair expressed from the neuroblastoma (NB) risk-associated 6p22.3 locus is important for retinoic acid-induced NB differentiation gene-regulatory network by controlling CHD7 stability via modulating the cellular localization of the ubiquitin specific protease USP36.</p>}},
  author       = {{Mondal, Tanmoy and Juvvuna, Prasanna Kumar and Kirkeby, Agnete and Mitra, Sanhita and Kosalai, Subazini Thankaswamy and Traxler, Larissa and Hertwig, Falk and Wernig-Zorc, Sara and Miranda, Caroline and Deland, Lily and Volland, Ruth and Bartenhagen, Christoph and Bartsch, Deniz and Bandaru, Sashidhar and Engesser, Anne and Subhash, Santhilal and Martinsson, Tommy and Carén, Helena and Akyürek, Levent M. and Kurian, Leo and Kanduri, Meena and Huarte, Maite and Kogner, Per and Fischer, Matthias}},
  issn         = {{1535-6108}},
  keywords     = {{CASC15; CHD7; lncRNA; long noncoding RNA; NBAT1; neuroblastoma; neuronal differentiation; SOX9; ubiquitination; USP36}},
  language     = {{eng}},
  month        = {{03}},
  number       = {{3}},
  pages        = {{7--434}},
  publisher    = {{Cell Press}},
  series       = {{Cancer Cell}},
  title        = {{Sense-Antisense lncRNA Pair Encoded by Locus 6p22.3 Determines Neuroblastoma Susceptibility via the USP36-CHD7-SOX9 Regulatory Axis}},
  url          = {{http://dx.doi.org/10.1016/j.ccell.2018.01.020}},
  doi          = {{10.1016/j.ccell.2018.01.020}},
  volume       = {{33}},
  year         = {{2018}},
}