Electronic speckle pattern interferometry: A novel non-invasive tool for studying drug transport rate through free films
(2006) In Journal of Controlled Release 114(3). p.369-380- Abstract
- In this work, Electronic Speckle Pattern Interferometry (ESPI) is presented as a non-invasive tool to study drug transport in controlled release systems. ESPI is shown to be a feasible tool to measure drug film permeability via comparison with an ordinary diaphragm cell. A specially designed cuvette was used in the release study: the polymeric film separated the donor and the receiving chambers of the cuvette to create a diffusion cell with no mixing in the two chambers. Thus, the cuvette mimicked a coated system immersed in a stagnant bulk liquid. Concentration profile data were obtained for the two compartments. Using these data, it was possible to visually discriminate between a film subject only to diffusion and a film subject to... (More)
- In this work, Electronic Speckle Pattern Interferometry (ESPI) is presented as a non-invasive tool to study drug transport in controlled release systems. ESPI is shown to be a feasible tool to measure drug film permeability via comparison with an ordinary diaphragm cell. A specially designed cuvette was used in the release study: the polymeric film separated the donor and the receiving chambers of the cuvette to create a diffusion cell with no mixing in the two chambers. Thus, the cuvette mimicked a coated system immersed in a stagnant bulk liquid. Concentration profile data were obtained for the two compartments. Using these data, it was possible to visually discriminate between a film subject only to diffusion and a film subject to diffusion as well as osmotic effects. Moreover, using the concentration profile data collected at different time intervals, it was possible to follow the film properties in terms of drug permeability, thus studying bow drug permeability depended on drug concentration. Compared to other measuring techniques, ESPI offers the advantages that no invasive measurements are needed, and that no sampling and calibration are required. Furthermore, the permeability can be measured with no influence of mass transfer in the boundary layers. (c) 2006 Elsevier B.V. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/387966
- author
- Marucci, Mariagrazia LU ; Ragnarsson, Gert and Axelsson, Anders LU
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- ESPI interferometry, osmosis, drug release, membrane, diffusion
- in
- Journal of Controlled Release
- volume
- 114
- issue
- 3
- pages
- 369 - 380
- publisher
- Elsevier
- external identifiers
-
- wos:000241177800011
- pmid:16904222
- scopus:33748143375
- pmid:16904222
- ISSN
- 1873-4995
- DOI
- 10.1016/j.jconrel.2006.06.019
- language
- English
- LU publication?
- yes
- id
- 6e390971-5dd4-4ee0-b26d-5f4b3f853e11 (old id 387966)
- date added to LUP
- 2016-04-01 12:18:49
- date last changed
- 2023-11-11 20:32:12
@article{6e390971-5dd4-4ee0-b26d-5f4b3f853e11,
abstract = {{In this work, Electronic Speckle Pattern Interferometry (ESPI) is presented as a non-invasive tool to study drug transport in controlled release systems. ESPI is shown to be a feasible tool to measure drug film permeability via comparison with an ordinary diaphragm cell. A specially designed cuvette was used in the release study: the polymeric film separated the donor and the receiving chambers of the cuvette to create a diffusion cell with no mixing in the two chambers. Thus, the cuvette mimicked a coated system immersed in a stagnant bulk liquid. Concentration profile data were obtained for the two compartments. Using these data, it was possible to visually discriminate between a film subject only to diffusion and a film subject to diffusion as well as osmotic effects. Moreover, using the concentration profile data collected at different time intervals, it was possible to follow the film properties in terms of drug permeability, thus studying bow drug permeability depended on drug concentration. Compared to other measuring techniques, ESPI offers the advantages that no invasive measurements are needed, and that no sampling and calibration are required. Furthermore, the permeability can be measured with no influence of mass transfer in the boundary layers. (c) 2006 Elsevier B.V. All rights reserved.}},
author = {{Marucci, Mariagrazia and Ragnarsson, Gert and Axelsson, Anders}},
issn = {{1873-4995}},
keywords = {{ESPI interferometry; osmosis; drug release; membrane; diffusion}},
language = {{eng}},
number = {{3}},
pages = {{369--380}},
publisher = {{Elsevier}},
series = {{Journal of Controlled Release}},
title = {{Electronic speckle pattern interferometry: A novel non-invasive tool for studying drug transport rate through free films}},
url = {{http://dx.doi.org/10.1016/j.jconrel.2006.06.019}},
doi = {{10.1016/j.jconrel.2006.06.019}},
volume = {{114}},
year = {{2006}},
}