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Electronic speckle pattern interferometry: A novel non-invasive tool for studying drug transport rate through free films

Marucci, Mariagrazia LU ; Ragnarsson, Gert and Axelsson, Anders LU (2006) In Journal of Controlled Release 114(3). p.369-380
Abstract
In this work, Electronic Speckle Pattern Interferometry (ESPI) is presented as a non-invasive tool to study drug transport in controlled release systems. ESPI is shown to be a feasible tool to measure drug film permeability via comparison with an ordinary diaphragm cell. A specially designed cuvette was used in the release study: the polymeric film separated the donor and the receiving chambers of the cuvette to create a diffusion cell with no mixing in the two chambers. Thus, the cuvette mimicked a coated system immersed in a stagnant bulk liquid. Concentration profile data were obtained for the two compartments. Using these data, it was possible to visually discriminate between a film subject only to diffusion and a film subject to... (More)
In this work, Electronic Speckle Pattern Interferometry (ESPI) is presented as a non-invasive tool to study drug transport in controlled release systems. ESPI is shown to be a feasible tool to measure drug film permeability via comparison with an ordinary diaphragm cell. A specially designed cuvette was used in the release study: the polymeric film separated the donor and the receiving chambers of the cuvette to create a diffusion cell with no mixing in the two chambers. Thus, the cuvette mimicked a coated system immersed in a stagnant bulk liquid. Concentration profile data were obtained for the two compartments. Using these data, it was possible to visually discriminate between a film subject only to diffusion and a film subject to diffusion as well as osmotic effects. Moreover, using the concentration profile data collected at different time intervals, it was possible to follow the film properties in terms of drug permeability, thus studying bow drug permeability depended on drug concentration. Compared to other measuring techniques, ESPI offers the advantages that no invasive measurements are needed, and that no sampling and calibration are required. Furthermore, the permeability can be measured with no influence of mass transfer in the boundary layers. (c) 2006 Elsevier B.V. All rights reserved. (Less)
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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
ESPI interferometry, osmosis, drug release, membrane, diffusion
in
Journal of Controlled Release
volume
114
issue
3
pages
369 - 380
publisher
Elsevier
external identifiers
  • wos:000241177800011
  • pmid:16904222
  • scopus:33748143375
  • pmid:16904222
ISSN
1873-4995
DOI
10.1016/j.jconrel.2006.06.019
language
English
LU publication?
yes
id
6e390971-5dd4-4ee0-b26d-5f4b3f853e11 (old id 387966)
date added to LUP
2016-04-01 12:18:49
date last changed
2021-05-25 02:43:53
@article{6e390971-5dd4-4ee0-b26d-5f4b3f853e11,
  abstract     = {In this work, Electronic Speckle Pattern Interferometry (ESPI) is presented as a non-invasive tool to study drug transport in controlled release systems. ESPI is shown to be a feasible tool to measure drug film permeability via comparison with an ordinary diaphragm cell. A specially designed cuvette was used in the release study: the polymeric film separated the donor and the receiving chambers of the cuvette to create a diffusion cell with no mixing in the two chambers. Thus, the cuvette mimicked a coated system immersed in a stagnant bulk liquid. Concentration profile data were obtained for the two compartments. Using these data, it was possible to visually discriminate between a film subject only to diffusion and a film subject to diffusion as well as osmotic effects. Moreover, using the concentration profile data collected at different time intervals, it was possible to follow the film properties in terms of drug permeability, thus studying bow drug permeability depended on drug concentration. Compared to other measuring techniques, ESPI offers the advantages that no invasive measurements are needed, and that no sampling and calibration are required. Furthermore, the permeability can be measured with no influence of mass transfer in the boundary layers. (c) 2006 Elsevier B.V. All rights reserved.},
  author       = {Marucci, Mariagrazia and Ragnarsson, Gert and Axelsson, Anders},
  issn         = {1873-4995},
  language     = {eng},
  number       = {3},
  pages        = {369--380},
  publisher    = {Elsevier},
  series       = {Journal of Controlled Release},
  title        = {Electronic speckle pattern interferometry: A novel non-invasive tool for studying drug transport rate through free films},
  url          = {http://dx.doi.org/10.1016/j.jconrel.2006.06.019},
  doi          = {10.1016/j.jconrel.2006.06.019},
  volume       = {114},
  year         = {2006},
}