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Towards in vivo neurochemical profiling of multiple sclerosis with MR spectroscopy at 7 Tesla: Apparent increase in frontal cortex water T2 in aged individuals with progressive multiple sclerosis stabilizes in biexponential model constrained by tissue partial volumes

Swanberg, Kelley M. LU orcid ; Prinsen, Hetty ; Kurada, Abhinav V ; Fulbright, Robert K ; Pitt, David ; DeStefano, Katherine ; Bailey, Mary and Juchem, Christoph (2018) 2018.
Abstract
Water is a common internal reference for metabolite quantification by 1H-MRS. We investigate potential influences on water-referenced metabolite quantification by differences in frontal cortex water T2 in individuals with relapsing-remitting, progressive, and no multiple sclerosis. Water T2 differed in monoexponential models, exhibiting highest values in progressive multiple sclerosis only when analyses were not age-controlled. Groupwise T2 did not differ in biexponential models constrained by tissue and CSF partial volumes, suggesting that monoexponential T2 differences reflected disparate proportions of water in tissue and CSF rather than differential behavior within them. Our results suggest stability of water T2 within frontal cortex... (More)
Water is a common internal reference for metabolite quantification by 1H-MRS. We investigate potential influences on water-referenced metabolite quantification by differences in frontal cortex water T2 in individuals with relapsing-remitting, progressive, and no multiple sclerosis. Water T2 differed in monoexponential models, exhibiting highest values in progressive multiple sclerosis only when analyses were not age-controlled. Groupwise T2 did not differ in biexponential models constrained by tissue and CSF partial volumes, suggesting that monoexponential T2 differences reflected disparate proportions of water in tissue and CSF rather than differential behavior within them. Our results suggest stability of water T2 within frontal cortex tissue and CSF with multiple sclerosis and emphasize the superiority of metabolite quantification with group-specific T2 values when voxel composition may differ. (Less)
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publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
host publication
Proc Int Soc Magn Reson Med
volume
2018
language
English
LU publication?
no
id
387eaac0-3d70-46d8-a3da-db64ca2d9f9d
alternative location
https://archive.ismrm.org/2018/0161.html
date added to LUP
2023-09-18 15:55:38
date last changed
2024-08-07 09:45:26
@inproceedings{387eaac0-3d70-46d8-a3da-db64ca2d9f9d,
  abstract     = {{Water is a common internal reference for metabolite quantification by 1H-MRS. We investigate potential influences on water-referenced metabolite quantification by differences in frontal cortex water T2 in individuals with relapsing-remitting, progressive, and no multiple sclerosis. Water T2 differed in monoexponential models, exhibiting highest values in progressive multiple sclerosis only when analyses were not age-controlled. Groupwise T2 did not differ in biexponential models constrained by tissue and CSF partial volumes, suggesting that monoexponential T2 differences reflected disparate proportions of water in tissue and CSF rather than differential behavior within them. Our results suggest stability of water T2 within frontal cortex tissue and CSF with multiple sclerosis and emphasize the superiority of metabolite quantification with group-specific T2 values when voxel composition may differ.}},
  author       = {{Swanberg, Kelley M. and Prinsen, Hetty and Kurada, Abhinav V and Fulbright, Robert K and Pitt, David and DeStefano, Katherine and Bailey, Mary and Juchem, Christoph}},
  booktitle    = {{Proc Int Soc Magn Reson Med}},
  language     = {{eng}},
  title        = {{Towards in vivo neurochemical profiling of multiple sclerosis with MR spectroscopy at 7 Tesla: Apparent increase in frontal cortex water T2 in aged individuals with progressive multiple sclerosis stabilizes in biexponential model constrained by tissue partial volumes}},
  url          = {{https://archive.ismrm.org/2018/0161.html}},
  volume       = {{2018}},
  year         = {{2018}},
}