Perinatal events and the risk of developing primary sclerosing cholangitis
(2006) In World Journal of Gastroenterology 12(37). p.6037-6040- Abstract
- AIM: To investigate whether perinatal events, intrauterine or postpartum, are associated with the development of primary sclerosing cholangitis (PSC) later in life. METHODS: Birth records from 97 patients with adult PSC in Sweden were reviewed. Information on perinatal events including medications and complications during pregnancy, gestation length, birth weight and length were collected. Two control children of the same sex were selected for each subject. Conditional multiple logistic regression was used to assess associations of the perinatal measures with development of PSC. RESULTS: No significant associations were found between gestational age, birth length, breastfeeding, and the majority of medical complications including... (More)
- AIM: To investigate whether perinatal events, intrauterine or postpartum, are associated with the development of primary sclerosing cholangitis (PSC) later in life. METHODS: Birth records from 97 patients with adult PSC in Sweden were reviewed. Information on perinatal events including medications and complications during pregnancy, gestation length, birth weight and length were collected. Two control children of the same sex were selected for each subject. Conditional multiple logistic regression was used to assess associations of the perinatal measures with development of PSC. RESULTS: No significant associations were found between gestational age, birth length, breastfeeding, and the majority of medical complications including infections or medication during pregnancy for the mothers or postpartum for the children. Vaginal bleeding and peripheral oedema showed associations with PSC, with matched odds ratios of 5.70 (95% CI, 1.13-28.83) and 2.28 (95% CI, 1.04-5.03), respectively. CONCLUSION: The associations of vaginal bleeding and oedema with subsequent PSC cannot readily be explained, so our findings do not strongly support the hypothesis of a significant role of perinatal events as a risk for the development of PSC later in life. (C) 2006 The WJG Press. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/388276
- author
- Bergquist, Annika ; Montgomery, Scott M. ; Lund, Ulrika ; Ekbom, Anders ; Olsson, Rolf ; Lindgren, Stefan LU ; Prytz, Hanne LU ; Hultcrantz, Rolf and Broome, Ulrika
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- inflammatory bowel disease, perinatal factors, sclerosing cholangitis
- in
- World Journal of Gastroenterology
- volume
- 12
- issue
- 37
- pages
- 6037 - 6040
- publisher
- WJG Press
- external identifiers
-
- wos:000241216400018
- scopus:33750275750
- ISSN
- 1007-9327
- language
- English
- LU publication?
- yes
- id
- aaabfbba-804f-4130-bc1d-0d5e97e8623a (old id 388276)
- alternative location
- http://www.wjgnet.com/1007-9327/12/6037.asp
- date added to LUP
- 2016-04-01 12:25:03
- date last changed
- 2024-01-08 19:46:04
@article{aaabfbba-804f-4130-bc1d-0d5e97e8623a,
abstract = {{AIM: To investigate whether perinatal events, intrauterine or postpartum, are associated with the development of primary sclerosing cholangitis (PSC) later in life. METHODS: Birth records from 97 patients with adult PSC in Sweden were reviewed. Information on perinatal events including medications and complications during pregnancy, gestation length, birth weight and length were collected. Two control children of the same sex were selected for each subject. Conditional multiple logistic regression was used to assess associations of the perinatal measures with development of PSC. RESULTS: No significant associations were found between gestational age, birth length, breastfeeding, and the majority of medical complications including infections or medication during pregnancy for the mothers or postpartum for the children. Vaginal bleeding and peripheral oedema showed associations with PSC, with matched odds ratios of 5.70 (95% CI, 1.13-28.83) and 2.28 (95% CI, 1.04-5.03), respectively. CONCLUSION: The associations of vaginal bleeding and oedema with subsequent PSC cannot readily be explained, so our findings do not strongly support the hypothesis of a significant role of perinatal events as a risk for the development of PSC later in life. (C) 2006 The WJG Press. All rights reserved.}},
author = {{Bergquist, Annika and Montgomery, Scott M. and Lund, Ulrika and Ekbom, Anders and Olsson, Rolf and Lindgren, Stefan and Prytz, Hanne and Hultcrantz, Rolf and Broome, Ulrika}},
issn = {{1007-9327}},
keywords = {{inflammatory bowel disease; perinatal factors; sclerosing cholangitis}},
language = {{eng}},
number = {{37}},
pages = {{6037--6040}},
publisher = {{WJG Press}},
series = {{World Journal of Gastroenterology}},
title = {{Perinatal events and the risk of developing primary sclerosing cholangitis}},
url = {{http://www.wjgnet.com/1007-9327/12/6037.asp}},
volume = {{12}},
year = {{2006}},
}