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Preparation of molecularly imprinted polymers using nitroxide-mediated living radical polymerization

Boonpangrak, Somchai LU ; Whitcombe, Michael J. ; Prachayasittikul, Virapong ; Mosbach, Klaus and Ye, Lei LU orcid (2006) In Biosensors & Bioelectronics 22(3). p.349-354
Abstract
The use of molecularly imprinted polymers (MIPs) in chemical and bioanalytical applications has been gaining in interest in recent years. Compared to their biological receptor counterparts, MIP's are easy to prepare, have long shelf stability and can be used under a variety of harsh conditions. The majority of MIPs currently used are produced by traditional free radical polymerization. One drawback with the use of standard free radical initiators is that little control can be exerted over the chemical processes that form the final imprinted cavities. In this study we set out to investigate the application of controlled (living) free radical polymerization to the preparation of MIPs. This was exemplified by the synthesis of... (More)
The use of molecularly imprinted polymers (MIPs) in chemical and bioanalytical applications has been gaining in interest in recent years. Compared to their biological receptor counterparts, MIP's are easy to prepare, have long shelf stability and can be used under a variety of harsh conditions. The majority of MIPs currently used are produced by traditional free radical polymerization. One drawback with the use of standard free radical initiators is that little control can be exerted over the chemical processes that form the final imprinted cavities. In this study we set out to investigate the application of controlled (living) free radical polymerization to the preparation of MIPs. This was exemplified by the synthesis of cholesterol-imprinted bulk polymers by nitroxide-mediated polymerization (NMP). A sacrificial covalent bond was employed to maintain imprinting fidelity at elevated temperature. Selective uptake of cholesterol from solutions in hexane was studied with imprinted polymers prepared under different conditions. The imprinted hydrolyzed MIP prepared by NMP displayed higher selective cholesterol binding than that prepared by a traditional radical polymerization. (c) 2006 Elsevier B.V. All rights reserved. (Less)
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
polymerization, nitroxide-mediated, molecular imprinting, living radical polymerization, cholesterol
in
Biosensors & Bioelectronics
volume
22
issue
3
pages
349 - 354
publisher
Elsevier
external identifiers
  • wos:000241023300003
  • scopus:33748132182
ISSN
1873-4235
DOI
10.1016/j.bios.2006.04.014
language
English
LU publication?
yes
id
3596f4d2-62b3-4a01-b68d-9dccc95da686 (old id 388572)
date added to LUP
2016-04-01 16:16:29
date last changed
2021-10-06 03:05:46
@article{3596f4d2-62b3-4a01-b68d-9dccc95da686,
  abstract     = {The use of molecularly imprinted polymers (MIPs) in chemical and bioanalytical applications has been gaining in interest in recent years. Compared to their biological receptor counterparts, MIP's are easy to prepare, have long shelf stability and can be used under a variety of harsh conditions. The majority of MIPs currently used are produced by traditional free radical polymerization. One drawback with the use of standard free radical initiators is that little control can be exerted over the chemical processes that form the final imprinted cavities. In this study we set out to investigate the application of controlled (living) free radical polymerization to the preparation of MIPs. This was exemplified by the synthesis of cholesterol-imprinted bulk polymers by nitroxide-mediated polymerization (NMP). A sacrificial covalent bond was employed to maintain imprinting fidelity at elevated temperature. Selective uptake of cholesterol from solutions in hexane was studied with imprinted polymers prepared under different conditions. The imprinted hydrolyzed MIP prepared by NMP displayed higher selective cholesterol binding than that prepared by a traditional radical polymerization. (c) 2006 Elsevier B.V. All rights reserved.},
  author       = {Boonpangrak, Somchai and Whitcombe, Michael J. and Prachayasittikul, Virapong and Mosbach, Klaus and Ye, Lei},
  issn         = {1873-4235},
  language     = {eng},
  number       = {3},
  pages        = {349--354},
  publisher    = {Elsevier},
  series       = {Biosensors & Bioelectronics},
  title        = {Preparation of molecularly imprinted polymers using nitroxide-mediated living radical polymerization},
  url          = {http://dx.doi.org/10.1016/j.bios.2006.04.014},
  doi          = {10.1016/j.bios.2006.04.014},
  volume       = {22},
  year         = {2006},
}