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Encapsulation and selective recognition of molecularly imprinted theophylline and 17 ss-estradiol nanoparticles within electrospun polymer nanofibers

Chronakis, Ioannis S. ; Jakob, Alexandra ; Hagstrom, Bengt and Ye, Lei LU orcid (2006) In Langmuir 22(21). p.8960-8965
Abstract
Molecularly imprinted nanoparticles are cross-linked polymer colloids containing tailor-made molecular recognition sites. In this study, molecularly imprinted nanoparticles were easily encapsulated within polymer nanofibers using an electrospinning technique to produce a new type of molecular recognition material. Poly(ethylene terephthalate) (PET) was used as the supporting nanofibers matrix to encapsulate theophylline and 17 beta-estradiol imprinted nanoparticles. The composite nanofibers had an average diameter of 150-300 nm, depending on the content of molecularly imprinted nanoparticles. For the theophylline and 17 beta-estradiol imprinted polymers, an optimal loading of molecularly imprinted nanoparticles was 25-37.5 wt % based on... (More)
Molecularly imprinted nanoparticles are cross-linked polymer colloids containing tailor-made molecular recognition sites. In this study, molecularly imprinted nanoparticles were easily encapsulated within polymer nanofibers using an electrospinning technique to produce a new type of molecular recognition material. Poly(ethylene terephthalate) (PET) was used as the supporting nanofibers matrix to encapsulate theophylline and 17 beta-estradiol imprinted nanoparticles. The composite nanofibers had an average diameter of 150-300 nm, depending on the content of molecularly imprinted nanoparticles. For the theophylline and 17 beta-estradiol imprinted polymers, an optimal loading of molecularly imprinted nanoparticles was 25-37.5 wt % based on PET. The composite nanofibers prepared under these conditions had a well-defined morphology and displayed the best selective target recognition. Our approach of electrospinning-for-molecularly imprinted nanoparticles-encapsulation has unique advantages and opens new application opportunities for molecularly imprinted nanoparticles and electrospun nanofibers. (Less)
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Langmuir
volume
22
issue
21
pages
8960 - 8965
publisher
The American Chemical Society (ACS)
external identifiers
  • wos:000240954300050
  • scopus:33750329522
  • pmid:17014141
ISSN
0743-7463
DOI
10.1021/la0613880
language
English
LU publication?
yes
id
898203c9-7d62-4b6f-a15b-21238098a84b (old id 389493)
date added to LUP
2016-04-01 12:29:44
date last changed
2021-09-15 02:05:54
@article{898203c9-7d62-4b6f-a15b-21238098a84b,
  abstract     = {Molecularly imprinted nanoparticles are cross-linked polymer colloids containing tailor-made molecular recognition sites. In this study, molecularly imprinted nanoparticles were easily encapsulated within polymer nanofibers using an electrospinning technique to produce a new type of molecular recognition material. Poly(ethylene terephthalate) (PET) was used as the supporting nanofibers matrix to encapsulate theophylline and 17 beta-estradiol imprinted nanoparticles. The composite nanofibers had an average diameter of 150-300 nm, depending on the content of molecularly imprinted nanoparticles. For the theophylline and 17 beta-estradiol imprinted polymers, an optimal loading of molecularly imprinted nanoparticles was 25-37.5 wt % based on PET. The composite nanofibers prepared under these conditions had a well-defined morphology and displayed the best selective target recognition. Our approach of electrospinning-for-molecularly imprinted nanoparticles-encapsulation has unique advantages and opens new application opportunities for molecularly imprinted nanoparticles and electrospun nanofibers.},
  author       = {Chronakis, Ioannis S. and Jakob, Alexandra and Hagstrom, Bengt and Ye, Lei},
  issn         = {0743-7463},
  language     = {eng},
  number       = {21},
  pages        = {8960--8965},
  publisher    = {The American Chemical Society (ACS)},
  series       = {Langmuir},
  title        = {Encapsulation and selective recognition of molecularly imprinted theophylline and 17 ss-estradiol nanoparticles within electrospun polymer nanofibers},
  url          = {http://dx.doi.org/10.1021/la0613880},
  doi          = {10.1021/la0613880},
  volume       = {22},
  year         = {2006},
}