Preparation of molecularly imprinted polymers in supercritical carbon dioxide
Ye, Lei LU
; Yoshimatsu, Keiichi
LU
; Kolodziej, Dorota
LU
; da Cruz Francisco, José
LU
and Dey, Estera
LU
(2006)
In Journal of Applied Polymer Science
102(3).
p.2863-2867
- Abstract
- Molecularly imprinted polymer nanoparticles were prepared in supercritical carbon dioxide using a noncovalent imprinting approach. In the present work, propranolol was used as a model template, methacrylic acid as a functional monomer, and divinylbenzene as a crosslinker. Under a high dilution condition, the heterogeneous polymerization resulted in discrete crosslinked polymer nanoparticles. Compared with the nonimprinted polymers, the imprinted nanoparticles displayed much higher propranolol uptake in a low polarity organic solvent. The use of a single enantiomer (S)-propranolol as the template clearly demonstrated that the imprinted binding sites are chiral-selective, with a cross-reactivity towards (R)-propranolol of less than 5%. The... (More)
- Molecularly imprinted polymer nanoparticles were prepared in supercritical carbon dioxide using a noncovalent imprinting approach. In the present work, propranolol was used as a model template, methacrylic acid as a functional monomer, and divinylbenzene as a crosslinker. Under a high dilution condition, the heterogeneous polymerization resulted in discrete crosslinked polymer nanoparticles. Compared with the nonimprinted polymers, the imprinted nanoparticles displayed much higher propranolol uptake in a low polarity organic solvent. The use of a single enantiomer (S)-propranolol as the template clearly demonstrated that the imprinted binding sites are chiral-selective, with a cross-reactivity towards (R)-propranolol of less than 5%. The overall binding performance of the imprinted nanoparticles was comparable to imprinted polymers prepared in conventional organic solvents. (c) 2006 Wiley Periodicals, Inc. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/389577
- author
- Ye, Lei
LU
; Yoshimatsu, Keiichi
LU
; Kolodziej, Dorota
LU
; da Cruz Francisco, José
LU
and Dey, Estera
LU
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- propranolol, molecular imprinting, supercritical carbon dioxide
- in
- Journal of Applied Polymer Science
- volume
- 102
- issue
- 3
- pages
- 2863 - 2867
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000240923900107
- scopus:33750347997
- ISSN
- 1097-4628
- DOI
- 10.1002/app.24648
- language
- English
- LU publication?
- yes
- id
- d48f23ef-ad77-4bef-ba78-8b73e0bd1bfc (old id 389577)
- date added to LUP
- 2016-04-01 12:24:01
- date last changed
- 2022-04-21 06:54:19
@article{d48f23ef-ad77-4bef-ba78-8b73e0bd1bfc,
abstract = {{Molecularly imprinted polymer nanoparticles were prepared in supercritical carbon dioxide using a noncovalent imprinting approach. In the present work, propranolol was used as a model template, methacrylic acid as a functional monomer, and divinylbenzene as a crosslinker. Under a high dilution condition, the heterogeneous polymerization resulted in discrete crosslinked polymer nanoparticles. Compared with the nonimprinted polymers, the imprinted nanoparticles displayed much higher propranolol uptake in a low polarity organic solvent. The use of a single enantiomer (S)-propranolol as the template clearly demonstrated that the imprinted binding sites are chiral-selective, with a cross-reactivity towards (R)-propranolol of less than 5%. The overall binding performance of the imprinted nanoparticles was comparable to imprinted polymers prepared in conventional organic solvents. (c) 2006 Wiley Periodicals, Inc.}},
author = {{Ye, Lei and Yoshimatsu, Keiichi and Kolodziej, Dorota and da Cruz Francisco, José and Dey, Estera}},
issn = {{1097-4628}},
keywords = {{propranolol; molecular imprinting; supercritical carbon dioxide}},
language = {{eng}},
number = {{3}},
pages = {{2863--2867}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Journal of Applied Polymer Science}},
title = {{Preparation of molecularly imprinted polymers in supercritical carbon dioxide}},
url = {{http://dx.doi.org/10.1002/app.24648}},
doi = {{10.1002/app.24648}},
volume = {{102}},
year = {{2006}},
}