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Preparation of molecularly imprinted polymers in supercritical carbon dioxide

Ye, Lei LU orcid ; Yoshimatsu, Keiichi LU ; Kolodziej, Dorota LU ; da Cruz Francisco, José LU and Dey, Estera LU (2006) In Journal of Applied Polymer Science 102(3). p.2863-2867
Abstract
Molecularly imprinted polymer nanoparticles were prepared in supercritical carbon dioxide using a noncovalent imprinting approach. In the present work, propranolol was used as a model template, methacrylic acid as a functional monomer, and divinylbenzene as a crosslinker. Under a high dilution condition, the heterogeneous polymerization resulted in discrete crosslinked polymer nanoparticles. Compared with the nonimprinted polymers, the imprinted nanoparticles displayed much higher propranolol uptake in a low polarity organic solvent. The use of a single enantiomer (S)-propranolol as the template clearly demonstrated that the imprinted binding sites are chiral-selective, with a cross-reactivity towards (R)-propranolol of less than 5%. The... (More)
Molecularly imprinted polymer nanoparticles were prepared in supercritical carbon dioxide using a noncovalent imprinting approach. In the present work, propranolol was used as a model template, methacrylic acid as a functional monomer, and divinylbenzene as a crosslinker. Under a high dilution condition, the heterogeneous polymerization resulted in discrete crosslinked polymer nanoparticles. Compared with the nonimprinted polymers, the imprinted nanoparticles displayed much higher propranolol uptake in a low polarity organic solvent. The use of a single enantiomer (S)-propranolol as the template clearly demonstrated that the imprinted binding sites are chiral-selective, with a cross-reactivity towards (R)-propranolol of less than 5%. The overall binding performance of the imprinted nanoparticles was comparable to imprinted polymers prepared in conventional organic solvents. (c) 2006 Wiley Periodicals, Inc. (Less)
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
propranolol, molecular imprinting, supercritical carbon dioxide
in
Journal of Applied Polymer Science
volume
102
issue
3
pages
2863 - 2867
publisher
John Wiley and Sons
external identifiers
  • wos:000240923900107
  • scopus:33750347997
ISSN
1097-4628
DOI
10.1002/app.24648
language
English
LU publication?
yes
id
d48f23ef-ad77-4bef-ba78-8b73e0bd1bfc (old id 389577)
date added to LUP
2016-04-01 12:24:01
date last changed
2021-09-15 03:11:23
@article{d48f23ef-ad77-4bef-ba78-8b73e0bd1bfc,
  abstract     = {Molecularly imprinted polymer nanoparticles were prepared in supercritical carbon dioxide using a noncovalent imprinting approach. In the present work, propranolol was used as a model template, methacrylic acid as a functional monomer, and divinylbenzene as a crosslinker. Under a high dilution condition, the heterogeneous polymerization resulted in discrete crosslinked polymer nanoparticles. Compared with the nonimprinted polymers, the imprinted nanoparticles displayed much higher propranolol uptake in a low polarity organic solvent. The use of a single enantiomer (S)-propranolol as the template clearly demonstrated that the imprinted binding sites are chiral-selective, with a cross-reactivity towards (R)-propranolol of less than 5%. The overall binding performance of the imprinted nanoparticles was comparable to imprinted polymers prepared in conventional organic solvents. (c) 2006 Wiley Periodicals, Inc.},
  author       = {Ye, Lei and Yoshimatsu, Keiichi and Kolodziej, Dorota and da Cruz Francisco, José and Dey, Estera},
  issn         = {1097-4628},
  language     = {eng},
  number       = {3},
  pages        = {2863--2867},
  publisher    = {John Wiley and Sons},
  series       = {Journal of Applied Polymer Science},
  title        = {Preparation of molecularly imprinted polymers in supercritical carbon dioxide},
  url          = {http://dx.doi.org/10.1002/app.24648},
  doi          = {10.1002/app.24648},
  volume       = {102},
  year         = {2006},
}