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Effect of maternal dexamethasone and alpha-ketoglutarate administration on skeletal development during the last three weeks of prenatal life in pigs

Sliwa, E. ; Tatara, M. R. ; Nowakowski, H. ; Pierzynowski, Stefan LU and Studzinski, T. (2006) In Journal of Maternal-Fetal & Neonatal Medicine 19(8). p.489-493
Abstract
Background. The effect of dexamethasone (Dex) on postnatal bone formation processes is known to decrease the synthesis of collagen and bone matrix, but the effect of alpha-ketoglutarate (AKG) is to induce positive effects on growth and skeletal development during postnatal life. However, the effects of Dex and AKG treatment on the prenatal processes of skeletal development have not been investigated so far. Objective. The aim of this study was to determine the effect of Dex and AKG administered separately or simultaneously to sows during the last three weeks of pregnancy on the skeletal development in fetuses. Methods. Immediately after birth blood samples were collected from non-suckling piglets for alkaline phosphatase and osteocalcin... (More)
Background. The effect of dexamethasone (Dex) on postnatal bone formation processes is known to decrease the synthesis of collagen and bone matrix, but the effect of alpha-ketoglutarate (AKG) is to induce positive effects on growth and skeletal development during postnatal life. However, the effects of Dex and AKG treatment on the prenatal processes of skeletal development have not been investigated so far. Objective. The aim of this study was to determine the effect of Dex and AKG administered separately or simultaneously to sows during the last three weeks of pregnancy on the skeletal development in fetuses. Methods. Immediately after birth blood samples were collected from non-suckling piglets for alkaline phosphatase and osteocalcin determinations, and the humeri were isolated. Bone mineral density (BMD) and bone mineral content (BMC) of humeri and the geometric and mechanical properties were evaluated. Results. Dex and AKG administered separately to pregnant sows during the last 24 days of prenatal life decreased BMD, BMC, and geometric and mechanical parameters of humeri in the newborns. Simultaneous administration of Dex and AKG significantly increased the analyzed properties of humeri. Conclusion. The bone mineral density and mechanical and geometric properties of humeri indicate an inverse effect of maternal separate or simultaneous administration of AKG and Dex to sows on bone development during the last 24 days of prenatal life. (Less)
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
prenatal development of, ketoglutarate, alpha, newborn, dexamethasone, skeletal system
in
Journal of Maternal-Fetal & Neonatal Medicine
volume
19
issue
8
pages
489 - 493
publisher
Taylor & Francis
external identifiers
  • wos:000240874900007
  • scopus:33748525155
ISSN
1476-7058
DOI
10.1080/14767050600850381
language
English
LU publication?
yes
id
5c2ffc51-7411-4379-9ad5-aac9b501e8c7 (old id 389583)
date added to LUP
2016-04-01 12:34:22
date last changed
2020-05-20 01:58:44
@article{5c2ffc51-7411-4379-9ad5-aac9b501e8c7,
  abstract     = {Background. The effect of dexamethasone (Dex) on postnatal bone formation processes is known to decrease the synthesis of collagen and bone matrix, but the effect of alpha-ketoglutarate (AKG) is to induce positive effects on growth and skeletal development during postnatal life. However, the effects of Dex and AKG treatment on the prenatal processes of skeletal development have not been investigated so far. Objective. The aim of this study was to determine the effect of Dex and AKG administered separately or simultaneously to sows during the last three weeks of pregnancy on the skeletal development in fetuses. Methods. Immediately after birth blood samples were collected from non-suckling piglets for alkaline phosphatase and osteocalcin determinations, and the humeri were isolated. Bone mineral density (BMD) and bone mineral content (BMC) of humeri and the geometric and mechanical properties were evaluated. Results. Dex and AKG administered separately to pregnant sows during the last 24 days of prenatal life decreased BMD, BMC, and geometric and mechanical parameters of humeri in the newborns. Simultaneous administration of Dex and AKG significantly increased the analyzed properties of humeri. Conclusion. The bone mineral density and mechanical and geometric properties of humeri indicate an inverse effect of maternal separate or simultaneous administration of AKG and Dex to sows on bone development during the last 24 days of prenatal life.},
  author       = {Sliwa, E. and Tatara, M. R. and Nowakowski, H. and Pierzynowski, Stefan and Studzinski, T.},
  issn         = {1476-7058},
  language     = {eng},
  number       = {8},
  pages        = {489--493},
  publisher    = {Taylor & Francis},
  series       = {Journal of Maternal-Fetal & Neonatal Medicine},
  title        = {Effect of maternal dexamethasone and alpha-ketoglutarate administration on skeletal development during the last three weeks of prenatal life in pigs},
  url          = {http://dx.doi.org/10.1080/14767050600850381},
  doi          = {10.1080/14767050600850381},
  volume       = {19},
  year         = {2006},
}