Different outcome of allogeneic transplantation in myelofibrosis using conventional or reduced-intensity conditioning regimens
(2006) In British Journal of Haematology 135(3). p.367-373- Abstract
- Allogeneic haematopoietic stem cell transplantation remains the only curative treatment of myelofibrosis with myeloid metaplasia (MMM). Previous reports have indicated significant treatment-related mortality (TRM) for patients transplanted after myeloablative conditioning but superior survival has been reported after reduced-intensity conditioning (RIC). We report the results of a survey of all allogeneic transplantations for MMM performed in Sweden at six transplant units between 1982 and 2004. Twenty-seven patients were transplanted; 17 with a myeloablative conditioning regimen and 10 with RIC. The median age was 50 years (5-63 years) at transplantation. After a median follow up of 55 months, 20 patients are alive. TRM was 10% in the RIC... (More)
- Allogeneic haematopoietic stem cell transplantation remains the only curative treatment of myelofibrosis with myeloid metaplasia (MMM). Previous reports have indicated significant treatment-related mortality (TRM) for patients transplanted after myeloablative conditioning but superior survival has been reported after reduced-intensity conditioning (RIC). We report the results of a survey of all allogeneic transplantations for MMM performed in Sweden at six transplant units between 1982 and 2004. Twenty-seven patients were transplanted; 17 with a myeloablative conditioning regimen and 10 with RIC. The median age was 50 years (5-63 years) at transplantation. After a median follow up of 55 months, 20 patients are alive. TRM was 10% in the RIC group and 30% in the myeloablative group. There was no difference in survival for high or low-risk patients according to Cervantes score or between sibling and unrelated donor transplantations. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/389750
- author
- Merup, Mats ; Lazarevic, Vladimir LU ; Nahi, Hareth ; Andreasson, Bjorn ; Malm, Claes ; Nilsson, Lars ; Brune, Mats ; LeBlanc, Katarina ; Kutti, Jack and Birgegard, Gunnar
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- conditioning, reduced intensity, myelofibrosis, allogeneic transplantation, Cervantes score
- in
- British Journal of Haematology
- volume
- 135
- issue
- 3
- pages
- 367 - 373
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000240915800012
- scopus:33749259788
- ISSN
- 0007-1048
- DOI
- 10.1111/j.1365-2141.2006.06302.x
- language
- English
- LU publication?
- yes
- id
- 6b419876-233c-4a2d-98c0-ab46d93d7fa7 (old id 389750)
- date added to LUP
- 2016-04-01 11:59:32
- date last changed
- 2024-01-08 03:56:59
@article{6b419876-233c-4a2d-98c0-ab46d93d7fa7, abstract = {{Allogeneic haematopoietic stem cell transplantation remains the only curative treatment of myelofibrosis with myeloid metaplasia (MMM). Previous reports have indicated significant treatment-related mortality (TRM) for patients transplanted after myeloablative conditioning but superior survival has been reported after reduced-intensity conditioning (RIC). We report the results of a survey of all allogeneic transplantations for MMM performed in Sweden at six transplant units between 1982 and 2004. Twenty-seven patients were transplanted; 17 with a myeloablative conditioning regimen and 10 with RIC. The median age was 50 years (5-63 years) at transplantation. After a median follow up of 55 months, 20 patients are alive. TRM was 10% in the RIC group and 30% in the myeloablative group. There was no difference in survival for high or low-risk patients according to Cervantes score or between sibling and unrelated donor transplantations.}}, author = {{Merup, Mats and Lazarevic, Vladimir and Nahi, Hareth and Andreasson, Bjorn and Malm, Claes and Nilsson, Lars and Brune, Mats and LeBlanc, Katarina and Kutti, Jack and Birgegard, Gunnar}}, issn = {{0007-1048}}, keywords = {{conditioning; reduced intensity; myelofibrosis; allogeneic transplantation; Cervantes score}}, language = {{eng}}, number = {{3}}, pages = {{367--373}}, publisher = {{Wiley-Blackwell}}, series = {{British Journal of Haematology}}, title = {{Different outcome of allogeneic transplantation in myelofibrosis using conventional or reduced-intensity conditioning regimens}}, url = {{http://dx.doi.org/10.1111/j.1365-2141.2006.06302.x}}, doi = {{10.1111/j.1365-2141.2006.06302.x}}, volume = {{135}}, year = {{2006}}, }