Lactadherin binds to elastin - a starting point for medin amyloid formation?
(2006) In Amyloid 13(2). p.78-85- Abstract
- Medin amyloid is found in the medial layer of the aorta in almost 100% of the Caucasian population over 50 years of age. The medin fragment is 5.5 kDa and derives from the C2-like domain of the precursor protein lactadherin. We have previously reported immunohistochemical findings showing that medin amyloid co-localizes with elastic fibers of arteries and herein we show that lactadherin also is associated with elastic structures of human aortic material. In addition, results from in vitro binding assays demonstrate that both medin and lactadherin bind to tropoelastin in a concentration-dependent fashion, suggesting that the lactadherin-tropoelastin interaction is mediated via the medin domain. It is possible that lactadherin, which is a... (More)
- Medin amyloid is found in the medial layer of the aorta in almost 100% of the Caucasian population over 50 years of age. The medin fragment is 5.5 kDa and derives from the C2-like domain of the precursor protein lactadherin. We have previously reported immunohistochemical findings showing that medin amyloid co-localizes with elastic fibers of arteries and herein we show that lactadherin also is associated with elastic structures of human aortic material. In addition, results from in vitro binding assays demonstrate that both medin and lactadherin bind to tropoelastin in a concentration-dependent fashion, suggesting that the lactadherin-tropoelastin interaction is mediated via the medin domain. It is possible that lactadherin, which is a cell adhesion protein, in this way connects smooth muscle cells to the elastic fibers of arteries. Given that both medin and lactadherin interact with elastic fibers, elastin is probably an important component in the formation of medin amyloid. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/389830
- author
- Larsson, Annika ; Peng, Siwei ; Persson, Helena LU ; Rosenbloom, Joel ; Abrams, William R. ; Wassberg, Erik ; Thelin, Stefan ; Sletten, Knut ; Gerwins, Par and Westermark, Per
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- tropoelastin, lactadherin, medin, elastin, elastic fiber, amyloid, aorta
- in
- Amyloid
- volume
- 13
- issue
- 2
- pages
- 78 - 85
- publisher
- Parthenon Publishing
- external identifiers
-
- wos:000240931800003
- scopus:33747619664
- ISSN
- 1350-6129
- DOI
- 10.1080/13506120600722530
- language
- English
- LU publication?
- yes
- id
- 55def4a4-d674-43b3-999c-4877ea4a3623 (old id 389830)
- date added to LUP
- 2016-04-01 15:35:41
- date last changed
- 2022-02-27 07:46:49
@article{55def4a4-d674-43b3-999c-4877ea4a3623,
abstract = {{Medin amyloid is found in the medial layer of the aorta in almost 100% of the Caucasian population over 50 years of age. The medin fragment is 5.5 kDa and derives from the C2-like domain of the precursor protein lactadherin. We have previously reported immunohistochemical findings showing that medin amyloid co-localizes with elastic fibers of arteries and herein we show that lactadherin also is associated with elastic structures of human aortic material. In addition, results from in vitro binding assays demonstrate that both medin and lactadherin bind to tropoelastin in a concentration-dependent fashion, suggesting that the lactadherin-tropoelastin interaction is mediated via the medin domain. It is possible that lactadherin, which is a cell adhesion protein, in this way connects smooth muscle cells to the elastic fibers of arteries. Given that both medin and lactadherin interact with elastic fibers, elastin is probably an important component in the formation of medin amyloid.}},
author = {{Larsson, Annika and Peng, Siwei and Persson, Helena and Rosenbloom, Joel and Abrams, William R. and Wassberg, Erik and Thelin, Stefan and Sletten, Knut and Gerwins, Par and Westermark, Per}},
issn = {{1350-6129}},
keywords = {{tropoelastin; lactadherin; medin; elastin; elastic fiber; amyloid; aorta}},
language = {{eng}},
number = {{2}},
pages = {{78--85}},
publisher = {{Parthenon Publishing}},
series = {{Amyloid}},
title = {{Lactadherin binds to elastin - a starting point for medin amyloid formation?}},
url = {{http://dx.doi.org/10.1080/13506120600722530}},
doi = {{10.1080/13506120600722530}},
volume = {{13}},
year = {{2006}},
}