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Saliva-Induced Clotting Captures Streptococci : Novel Roles for Coagulation and Fibrinolysis in Host Defense and Immune Evasion

Wollein Waldetoft, Kristofer LU ; Mohanty, Tirthankar LU ; Karlsson, Christofer LU ; Mörgelin, Matthias LU ; Frick, Inga-Maria LU ; Malmström, Johan LU orcid and Björck, Lars LU (2016) In Infection and Immunity 84(10). p.23-2813
Abstract

Streptococcal pharyngitis is among the most common bacterial infections, but the molecular mechanisms involved remain poorly understood. Here we investigate the interactions among three major players in streptococcal pharyngitis: streptococci, plasma, and saliva. We find that saliva activates the plasma coagulation system through both the extrinsic and the intrinsic pathways, entrapping the bacteria in fibrin clots. The bacteria escape the clots by activating host plasminogen. Our results identify a potential function for the intrinsic pathway of coagulation in host defense and a corresponding role for fibrinolysis in streptococcal immune evasion.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Journal Article
in
Infection and Immunity
volume
84
issue
10
pages
11 pages
publisher
American Society for Microbiology
external identifiers
  • scopus:84994201506
  • wos:000384077800009
  • pmid:27456827
ISSN
1098-5522
DOI
10.1128/IAI.00307-16
language
English
LU publication?
yes
id
389aa8e6-6620-479c-8dca-0a90422c6819
date added to LUP
2016-11-14 22:18:20
date last changed
2025-04-04 15:05:11
@article{389aa8e6-6620-479c-8dca-0a90422c6819,
  abstract     = {{<p>Streptococcal pharyngitis is among the most common bacterial infections, but the molecular mechanisms involved remain poorly understood. Here we investigate the interactions among three major players in streptococcal pharyngitis: streptococci, plasma, and saliva. We find that saliva activates the plasma coagulation system through both the extrinsic and the intrinsic pathways, entrapping the bacteria in fibrin clots. The bacteria escape the clots by activating host plasminogen. Our results identify a potential function for the intrinsic pathway of coagulation in host defense and a corresponding role for fibrinolysis in streptococcal immune evasion.</p>}},
  author       = {{Wollein Waldetoft, Kristofer and Mohanty, Tirthankar and Karlsson, Christofer and Mörgelin, Matthias and Frick, Inga-Maria and Malmström, Johan and Björck, Lars}},
  issn         = {{1098-5522}},
  keywords     = {{Journal Article}},
  language     = {{eng}},
  number       = {{10}},
  pages        = {{23--2813}},
  publisher    = {{American Society for Microbiology}},
  series       = {{Infection and Immunity}},
  title        = {{Saliva-Induced Clotting Captures Streptococci : Novel Roles for Coagulation and Fibrinolysis in Host Defense and Immune Evasion}},
  url          = {{http://dx.doi.org/10.1128/IAI.00307-16}},
  doi          = {{10.1128/IAI.00307-16}},
  volume       = {{84}},
  year         = {{2016}},
}